Gut microbiota and health

Impact of gestational antibiotics on maternal and offspring gut microbiota and growth in pigs

This study examines how gestational antibiotics affect maternal and offspring gut microbiota and growth in pigs, finding altered microbial composition and growth patterns in piglets.

Engineering butyrate-producing Lachnospiraceae to treat metabolic disease

This paper engineers Lachnospiraceae bacteria to secrete IL-22, improving glucose homeostasis and reducing liver fat in a mouse model of metabolic disease.

Development of the preterm infant gut and gastric residuals microbiome

This study characterizes the gut and gastric residuals microbiome in preterm infants, identifying distinct microbial clusters and dynamics associated with clinical outcomes.

Cross-Fostering with control dams rescues Gut Dysbiosis and Chromatin-associated Transcriptional Changes in Offspring of Opioid-Exposed Dams

This study shows that cross-fostering opioid-exposed pups to naive dams rescues gut dysbiosis and chromatin-related transcriptional changes, suggesting microbiome-driven mechanisms in opioid-induced developmental injury.

A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis.

This study shows that a Muc2 mutation in Winnie mice leads to colitis-associated tumorigenesis driven by the gut microbiome and metabolome, with SPF conditions promoting severe disease and CAC.

Administration of short-chain fatty acids reduces bacterial translocation to peripheral organs and the brain, preserves gut barrier integrity, and mitigates brain injury following stroke.

This study shows that short-chain fatty acids reduce bacterial translocation after stroke, protect gut barrier integrity, and improve neurological outcomes in mice.

Niche dimensionality drives microbial community structure

The paper infers microbial niche dimensionality from abundance data and shows it correlates with environmental complexity, competition, and biodiversity in human gut microbiomes.

Nutrient competition predicts gut microbiome restructuring under drug perturbations

The paper shows that nutrient competition drives changes in gut microbiome composition under drug perturbations, with implications for predicting and mitigating drug side effects.

Perinatal Morphine Exposure Induces Long-Term Changes in the Intestinal Microbiota of Male and Female Rats

This study shows that perinatal morphine exposure in rats causes long-term intestinal microbiota changes that may affect immune system development and increase infection risk.

From sporulation to village differentiation: the shaping of the social microbiome over rural-to-urban lifestyle transition in Indonesia

The paper presents a gut microbiome dataset from Indonesia, revealing novel species and subspecies linked to rural-to-urban lifestyle transitions and showing that community-level diet differences drive microbiome divergence.

Robust Colonization of Nasal Microbiota Across the Respiratory Tract and the Gut Modulates Innate Immune Response in a Germ-Free Pig Model

This study investigates how nasal microbiota colonization in germ-free pigs affects immune responses and gut-lung axis interactions, showing antibiotic disruption of microbial diversity and immune gene expression.

Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits

The paper constructs a comprehensive gut microbiome reference database from Chinese and non-Chinese populations, revealing population-specific microbial features linked to host physiology.

Infant gut microbiota in multi-child families converges with adults without a sibling-specific signature

The paper analyzes infant gut microbiota in multi-child families and finds that sibling presence accelerates microbiota maturation but does not create a sibling-specific signature.

Host-specific bacterial modulation of airway gene expression and alternative splicing

This study shows that bacterial species and individual donors differentially modulate airway gene expression and alternative splicing in human epithelial cells.

The murine intestinal pathobiont Helicobacter hepaticus attenuates DSS colitis in a CD4+ T cell-dependent manner

This study shows that Helicobacter hepaticus colonization protects against DSS colitis by promoting anti-inflammatory CD4+ T cell responses.

Indirect environmental effects on the gut-brain axis in a wild mammal

The paper examines indirect environmental effects on the gut-brain axis in Siberian flying squirrels, finding age-dependent impacts on gut microbiota via glucocorticoids.

D- and L-lactate consumers in the human gut are taxonomically, biochemically, and energetically different

This study compares D- and L-lactate consumption by gut microbes, finding distinct microbial communities and metabolic pathways for each isomer.

Microbial succession at weaning is guided by microbial metabolism of host glycans.

This study shows that microbial succession during weaning is driven by the ability of microbes to metabolize host glycans, using a mouse model and genomic analysis.

Personalised whole-body modelling links gut microbiota to metabolic perturbations in Alzheimer's disease

The paper uses whole-body metabolic models to link gut microbiota to metabolic changes in Alzheimer's disease, identifying key microbial drivers and metabolites involved.

Maternal undernutrition exacerbates microbiota-driven growth stunting through pre and postnatal effects

This study shows maternal undernutrition worsens growth stunting in offspring through microbiota-dependent mechanisms, highlighting the need for interventions targeting both mothers and children.

Microbial Feast or Famine: dietary carbohydrate composition and gut microbiota metabolic function

This study uses metatranscriptomic data to analyze how dietary composition affects gut microbiota function, finding that a fiber-rich diet promotes beneficial metabolic pathways while a low-fiber diet increases harmful protein and mucin degradation.

High-altitude mountaineering induces adaptive gut microbiome shifts associated with dietary intake and performance markers

This study shows high-altitude mountaineering alters gut microbiome composition and function, linked to dietary intake and performance markers in alpinists.

Prevalence of Oxalotrophy in the Human Microbiome

The paper identifies oxalotrophy as a rare metabolic trait in the human microbiome, primarily confined to the gut, and finds evidence of horizontal gene transfer for the trait.

Similar Fecal SCFA Patterns Despite Diverse Gut Microbiota in Polish and Japanese Children During the First Two Years of Life. The longitudinal, comparative, validated study.

The paper compares gut microbiota and short-chain fatty acid (SCFA) patterns in Polish and Japanese children, finding similar SCFA trajectories despite divergent microbial communities.

Gut3Gel: A High Throughput Mucus Model for Culturing Human Intestinal Microbiota

Gut3Gel is a new in vitro mucus model that supports diverse intestinal microbiota growth and metabolic activity, offering a scalable platform for microbiota research.

A widespread hydrogenase drives fermentative growth of gut bacteria in healthy people

This study identifies the group B [FeFe]-hydrogenase as the primary enzyme driving fermentative H2 production in the human gut, linking it to gut health and disease.

Systematic Metaproteomics Mapping Reveals Functional and Ecological Landscapes of Ex Vivo Human Gut Microbiota Responses to Therapeutic Drugs

This study maps metaproteomic responses of human gut microbiota to 312 drugs, identifying 47 compounds that significantly alter microbial protein profiles and reveal functional state shifts.

Context-Dependent Metabolic Adaptation in Microbial Communities: From Monocultures to Complex Ecological Interactions

The paper investigates how microbial communities adapt metabolically in different environments, showing changes in carbon usage, biosynthesis, and interactions across monocultures, in vitro communities, and the mouse gut.

Gut Bacteria Metabolize Natural and Synthetic Steroid Hormones via the Reductive OsrABC Pathway

The paper identifies a novel gut bacterial pathway for steroid hormone metabolism and shows its impact on drug efficacy in Crohn's disease.

Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants

This study examines microbiota differences in chronic pancreatitis patients, showing distinct compositional and functional profiles between subtypes and controls.