Epilepsy research and treatment

Seizure Circuit Activity in the Theilers Murine Encephalomyelitis Virus Model of Infection-induced Epilepsy Using Transient Recombination in Active Populations.

This study uses TRAP to identify neuronal circuits involved in acute seizures during TMEV infection in mice, finding increased tdTomato expression in multiple brain regions.

CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizures

This study shows that brief CCR2 antagonism after seizures prevents cognitive deficits and neurodegeneration by blocking monocyte brain infiltration.

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice

In-vivo evidence for increased tau deposition in temporal lobe epilepsy

This study finds increased tau deposition in TLE patients using PET imaging, linked to cognitive impairment and brain connectivity patterns.

Inhibition of phosphodiesterase 4B as a novel therapeutic strategy for the treatment of refractory epilepsy

SN-2000, a novel PDE4B inhibitor, reduces seizure activity and shows psychiatric-neutral and pro-cognitive properties in preclinical models.

Human and Rodent Seizures Demonstrate a Dynamic Interplay with Spreading Depolarizations

This study shows that spreading depolarizations (SDs) are associated with seizure termination in both human and rodent models, with SDs reducing seizure duration and delaying subsequent events.

kcnb1 loss-of-function in zebrafish causes neurodevelopmental and epileptic disorders associated with GABA dysregulation

This paper characterizes a zebrafish kcnb1 knock-out model showing neurodevelopmental and epileptic features linked to GABA dysregulation.

Longitudinal deep phenotyping in a mouse model of West syndrome reveals temporal dynamics of synapse remodeling, gliosis, and proteomic and lipidomic changes during seizure evolution

This study uses longitudinal multi-omic analyses of a mouse model to show seizure evolution in West syndrome involves synaptic remodeling, gliosis, and proteomic/lipidomic changes over time.

Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomics

This study uses single-nucleus multiomics to map cell types and molecular changes in MOGHE lesions, identifying disease-specific oligodendrocytes and heterotopic neurons with altered gene expression.

Forecasting Seizure Duration from Neural Connectivity Patterns in a Neural Mass Model

This study uses a neural mass model to predict seizure duration from neural connectivity patterns in a rat epilepsy model, finding that preictal connectivity parameters can forecast seizure length with high accuracy.

New Insights into Epileptic Spasm Generation and Treatment from the TTX Animal Model

This paper uses a TTX animal model to show that reduced IGF-1 and inhibitory synapses in the neocortex cause epileptic spasms, and that (1-3)IGF-1 treatment can reverse these effects.

Bestrophin1-mediated GABA release activates large chloride currents to generate epileptiform events in the entorhinal cortex

The paper investigates how Bestrophin1-mediated GABA release generates chloride currents linked to epileptiform events in the entorhinal cortex using in vitro models.

Respiratory modulations of cortical excitabilityand interictal spike timing in focal epilepsy - a case report

This paper reports on respiration-modulated changes in excitation-inhibition balance and interictal spike timing in a focal epilepsy patient using MEG.

Base Editing Rescue of Seizures and SUDEP in SCN8A Developmental Epileptic Encephalopathy

This study uses base editing to correct the SCN8A R1872W mutation in mice, reducing seizures and improving survival and comorbidities.

Epileptiform activity and seizure risk follow long-term non-linear attractor dynamics

This paper uses HAVOK analysis to model nonlinear seizure dynamics and improves multi-day seizure risk forecasting by identifying short-period forcings.

A synonymous SLC2A1 variant causes familial epilepsy and paroxysmal exercise-induced dyskinesia by creating aberrant mosaic splicing patterns

This paper identifies a synonymous SLC2A1 variant causing GLUT1-DS through mosaic splicing, leading to variable haploinsufficiency and phenotypic diversity.

Persistent Na+ current couples seizure with spreading depolarization in Scn8a gain of function mice

This study shows that gain-of-function Scn8a mutations increase seizure and spreading depolarization in mice, and that persistent Na+ current contributes to this phenotype.

Pathogenic ultra-rare variants in SLC6A1, SLC6A11, GAD1 and GAD2 are new & recurrent GABAergic loci for GGE syndromes

The paper identifies ultra-rare variants in GABAergic genes associated with genetic generalized epilepsy syndromes and links their functional impact to epilepsy severity.

Optogenetic stimulation of dorsal striatum bidirectionally controls seizures

This study uses optogenetics to show that dorsal striatal activation suppresses seizures while silencing increases seizure activity in different epilepsy models.

Intestinal Dysbiosis Alters Acute Seizure Burden and Antiseizure Medicine Activity in the Theiler's Virus Model of Encephalitis

This study shows that antibiotic-induced gut dysbiosis alters seizure burden and carbamazepine anticonvulsant activity in a Theiler's virus encephalitis model without affecting drug plasma concentrations.

A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice

This paper describes a peptide-neurotensin conjugate that crosses the blood-brain barrier and induces pharmacological hypothermia with neuroprotective effects in a mouse model of status epilepticus.

Prior epigenetic status predicts future susceptibility to seizures in mice

The paper shows that epigenetic variation recorded in mice during development predicts seizure susceptibility, with specific loci linked to human epilepsy genes.

Cleavage of the TrkB-FL Receptor During Epileptogenesis: Insights from a Kainic Acid-Induced Model of Epilepsy and Human Samples

This study investigates TrkB-FL cleavage and TrkB-ICD formation during epileptogenesis in a rat model and human samples, finding a correlation with seizure severity and memory impairment.

Alterations in background ECoG activity and behavioral deficits in a mouse model of CHD2-related developmental delay

This paper characterizes behavioral and epileptic phenotypes in a CHD2 mutant mouse model, identifying genetic modifiers and altered ECoG activity associated with developmental delay.

Interictal discharges spread along local recurrent networks between tubers and surrounding cortex

This study links interictal epileptiform discharge spread to network coupling in tuberous sclerosis patients using EEG and neural mass modeling.

Human pulvinar stimulation engages select cortical pathways in epilepsy

This study shows that electrical stimulation of different pulvinar subregions in epilepsy patients evokes distinct patterns of brain activity in occipital, parietal, and temporal areas.

Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy

The astrocyte Fabp7 gene regulates diurnal seizure threshold and activity-dependent gene expression in mice

This study shows that Fabp7 in astrocytes affects seizure thresholds and gene expression in mice, with effects dependent on time-of-day.

Electrical Coordinated Reset Stimulation Induces Network Desynchronization in an in Vivo Model of Status Epilepticus

This study investigates the acute effects of Coordinated Reset stimulation on neural synchronization during Status Epilepticus in an in vivo model, showing reduced synchronization and connectivity measures.

Melanocortin 4 Receptor-Dependent Mechanism of ACTH in Preventing Anxiety-Like Behaviors and Normalizing Astrocyte Proteins After Early Life Seizures

This study shows ACTH prevents anxiety-like behaviors and normalizes astrocyte proteins after early life seizures via MC4R activation in neurons and astrocytes.