Nerve injury and regeneration

The node of Ranvier influences the in vivo axonal transport of mitochondria and signalling endosomes

The paper investigates axonal transport dynamics of signalling endosomes and mitochondria at the Node of Ranvier in vivo, finding reduced velocity and increased pausing during transit through the NoR.

Dnajc3 (HSP40) Enhances Axon Regeneration in the Mouse Optic Nerve

This study identifies Dnajc3 as a gene enhancing axon regeneration in mice by analyzing genomic variation across BXD strains and testing its effects on axon regeneration.

A triple serine motif in the intracellular domains of sortilin-related receptors SorCS1-3 regulates neurotrophic activity

This study identifies a triple serine motif in SorCS1-3 intracellular domains that regulates neurotrophic signaling through phosphorylation, leading to CREB activation and BDNF pathway modulation.

Chronically low NMNAT2 expression causes sub-lethal SARM1 activation and altered response to nicotinamide riboside in axons

This study shows that low NMNAT2 levels cause sub-lethal SARM1 activation and reduce the effectiveness of nicotinamide riboside in axons, leading to axonal defects and behavioral changes in mice.

PTEN Deletion Robustly Boosts BRAF-Driven Intraspinal Sensory Axon Regeneration

This study shows that deleting PTEN enhances BRAF-driven regeneration of injured sensory axons across the DREZ, enabling long-distance growth into the spinal cord.

Local glycolysis supports injury-induced axonal regeneration

The paper shows that local glycolysis supports axonal regeneration after injury by providing ATP, complementing mitochondrial metabolism.

Spontaneously regenerative corticospinal neurons in mice

The paper identifies a class of spontaneously regenerative corticospinal neurons in mice that project ipsilaterally and share molecular features with embryonic-like regenerating neurons.

Proteomic Investigation of Neurotrophic trans-Banglene Reveals Potential Link to Iron Homeostasis

The paper investigates the proteomic effects of neurotrophic trans-banglene (t-BG) and finds it alters iron-binding proteins, suggesting a link between iron homeostasis and neurotrophic activity.

Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis

This study identifies a subset of muscle-resident FAPs that respond to peripheral nerve injury via the GDNF-BDNF axis, contributing to remyelination and nerve regeneration.

Local synthesis of Reticulon-1C lessens the outgrowth of injured axons and Spastin activity

This study identifies Reticulon-1C as a locally synthesized axonal protein that modulates microtubule dynamics and axon outgrowth by regulating Spastin activity.

Synergistic control of axon regeneration and functional recovery by let-7 miRNA and Insulin signalling (IIs) pathways

This study shows that let-7 miRNA and Insulin signalling pathways work together to enhance axon regeneration and functional recovery in C. elegans neurons.

MLCK/MLCP regulates mammalian axon regeneration and redistributes the growth cone F-actin

This study shows that inhibiting MLCK blocks axon regeneration in mice, while inhibiting MLCP promotes regrowth in both peripheral and central nervous systems.

Sarm1 Gates the Transition from Protective to Repair Schwann Cell States Following Nerve Injury

This study shows Sarm1 promotes the transition from protective to repair Schwann cell states after nerve injury, with implications for neuropathies and neurodegenerative diseases.

p75NTR neurotrophin receptor function is redundant for development, growth and fertility in the rat.

This study generates p75NTR knockout rats to investigate its role in development and fertility, finding it largely dispensable for normal function.

Three-dimensional chromatin mapping of sensory neurons reveals that cohesin-dependent genomic domains are required for axonal regeneration

This study maps the 3D chromatin architecture of adult sensory neurons and shows cohesin is required for axonal regeneration by organizing genomic domains.

Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline

Inhibition of endothelin B receptor improves axon regeneration and reverses age-related decline in sensory neurons.

Trigeminal ganglion and tooth innervation modifications following genetic and pharmacological Nogo-A inhibition

This study shows that Nogo-A deletion affects trigeminal ganglion neurons and tooth innervation, altering synapse function and neurotrophin signaling.

Injury distance limits the transcriptional response to spinal injury

This study profiles the transcriptional response of supraspinal cell types to spinal injury in mice, finding that CST neurons respond more strongly to injuries closer to the brain than to distant spinal injuries.

Nerve injury converts Schwann cells in a persisting repair state in human neuroma tissue

The paper analyzes human neuroma tissue to show that Schwann cells remain in a repair state and are infiltrated by macrophages, with altered molecular signatures compared to healthy nerves.

Collagen I is a critical organizer of scarring and CNS regeneration failure

This study identifies collagen I as a key inhibitor of axonal regeneration in spinal cord injury and shows that aspirin and pirfenidone reduce collagen I and promote axonal growth.

The response of Dual-Leucine Zipper Kinase (DLK) to nocodazole: evidence for a homeostatic cytoskeletal repair mechanism

This study shows that DLK signaling is activated by low-dose nocodazole and mitigates microtubule damage, revealing a cytoskeletal homeostatic response pathway in neurons.

Nano-pulling stimulates axon regeneration in dorsal root ganglia by inducing stabilization of axonal microtubules and activation of local translation

The paper demonstrates that nano-pulling enhances axon regeneration in dorsal root ganglia by stabilizing microtubules and activating local translation.

Functional recovery associated with dendrite regeneration in PVD neuron of C. elegans

This study investigates how axon and dendrite regeneration in C. elegans PVD neurons affects sensory function and body posture recovery.

SKIN REINNERVATION BY COLLATERAL SPROUTING FOLLOWING SPARED NERVE INJURY IN MICE

This study examines collateral sprouting in denervated mouse skin, showing that some, but not all, neuronal subtypes reinnervate the area, restoring mechanosensation without hypersensitivity.

Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons

This study investigates the functional roles of Bdnf I and Bdnf IV transcript variants in hippocampal neurons using CRISPRa, finding distinct effects on dendritic growth and fear behavior.

The effectiveness of acellular nerve allografts compared to autografts in animal models: a systematic review and meta-analysis

This review and meta-analysis compare acellular nerve allografts to autografts in animal models, finding inferior nerve recovery with allografts in most outcomes, but no difference in amplitude.

Genetic dissection of BDNF and TrkB expression in glial cells

The paper uses genetic methods to investigate BDNF and TrkB expression in glial cells, finding no BDNF or TrkB in microglia and limited expression in astrocytes and oligodendrocytes.

Netrin4 is a new target specific factor, ensuring adult sympathetic neuron survival via promoting protein synthesis

The paper identifies Netrin4 as a factor essential for adult sympathetic neuron survival, showing it promotes protein synthesis and prevents necroptosis in specific neurons.

Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via epigenetic regulation of key regenerative pathways

This study shows Ezh2 promotes axon regeneration in the PNS and CNS by epigenetically regulating genes involved in regeneration and inhibitory signaling.

O-GlcNAc Signaling Increases Neuron Regeneration Through One-Carbon Metabolism in Caenorhabditis elegans

This study identifies O-GlcNAc signaling's role in enhancing neuron regeneration in C. elegans by redirecting metabolism towards one-carbon metabolism and transsulfuration pathways.