Nerve injury and regeneration

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in aged mice

The paper investigates how aging affects signaling endosome transport in motor axons and finds that processivity is impaired, which is not rescued by BDNF treatment due to reduced TrkB receptor expression.

PATZ1 Reinstates a Growth-Permissive Chromatin Landscape in Adult Corticospinal Neurons After Injury

This study maps chromatin accessibility changes in mouse forebrain development and shows that PATZ1 can reverse epigenetic restrictions in adult neurons to enhance axon regeneration after injury.

Dibutyryl cyclic AMP downregulates tenascin-C in neurons and astrocytes and reduces AAV-mediated gene expression in DRG neurons

This study investigates the combined effects of db-cAMP and integrin 9 overexpression on axonal regeneration in spinal cord injury models, finding mixed in vitro and in vivo results.

An intercellular signaling pathway in the mouse retina connects Kv2.1, GLT-1, and nitric oxide synthase 1 to optic nerve regeneration

This paper identifies a signaling pathway in the mouse retina involving Kv2.1, GLT-1, and NOS1 that promotes optic nerve regeneration after injury.

Conditioning electrical stimulation fails to enhance sympathetic axon regeneration

This study investigates the effects of conditioning electrical stimulation on sympathetic axon regeneration and finds no enhancement, suggesting limitations in its ability to activate small-caliber sympathetic axons.

Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair

The paper identifies five OEC subtypes in adult rats using single-cell RNA-sequencing, revealing their hybrid glial properties and roles in neural repair.

The Impact of Brain-Derived Neurotrophic Factor rs6265 (Val66Met) Polymorphism on Therapeutic Electrical Stimulation for Peripheral Nerve Regeneration: A Preclinical Study of Therapy-Genotype Interactions

This study examines how the rs6265 polymorphism affects the effectiveness of therapeutic electrical stimulation in peripheral nerve regeneration using rat models and human motor neurons.

Designed NGF mimetics with reduced nociceptive signatures in neurons

The paper designs TrkA agonists that activate neuronal differentiation and neurite outgrowth without triggering pain-related gene expression.

Endurance Exercise Elevates Plasma Mature Brain-Derived Neurotrophic Factor through Child- and Adulthood, with Amplified Effects in Adults

This study shows that endurance exercise increases plasma mature BDNF (mBDNF) in children, adolescents, and adults, with a greater response in adults, and that regular vigorous activity in youth correlates with higher basal mBDNF levels.

Regenerative failure of sympathetic axons contributes to deficits in functional recovery after nerve injury

This study investigates sympathetic axon regeneration after nerve injury and finds that it is not enhanced by common treatments and may contribute to long-term muscle atrophy and energy deficits.

The mechanotransduction protein STOML3 is required for functional plasticity following peripheral nerve regeneration

This study shows that STOML3 is necessary for functional plasticity after peripheral nerve regeneration, as its absence prevents muscle afferents from forming functional mechanosensitive receptive fields despite anatomical plasticity.

Axonal spheroids are regulated by Schwann cells after peripheral nerve injury

The paper identifies how Schwann cells regulate axonal spheroid fates after peripheral nerve injury in zebrafish, showing three outcomes: shrinking, breakdown, and uniform disappearance.

GABA and glycine synaptic release on axotomized motoneuron cell bodies promotes motor axon regeneration

This study shows that blocking GABA/glycine synaptic release on axotomized motoneurons slows motor axon regeneration and muscle reinnervation.

Predicting the Regenerative Potential of Retinal Ganglion Cells Based on Developmental Growth Trajectories

This study shows that retinal ganglion cell regenerative potential is linked to their developmental maturation timeline, with sON cells showing greater injury-induced regression than tON cells.

Disruption of G3BP1 Granules Promotes Mammalian CNS and PNS Axon Regeneration

This paper shows that disrupting G3BP1 granules promotes axon regeneration in both CNS and PNS injuries, suggesting a therapeutic strategy for neural repair.

Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

This study identifies an axon-specific microtubule-associated protein signature that drives asymmetric regeneration in sensory neuron axons, using an in vitro model of DRG neurons.

Loss of Sarm1 Mitigates Axonal and Neuronal Degeneration and Promotes Neuronal Repair After Ischemic Stroke

This study shows that loss of Sarm1 reduces axonal degeneration and promotes neuronal repair after ischemic stroke by activating a pro-growth molecular program.

Nerve Growth Factor Signaling Tunes Axon Maintenance Protein Abundance and Kinetics of Wallerian Degeneration

This study shows NGF signaling affects axon maintenance protein levels and Wallerian degeneration kinetics by modulating proteostasis and phospholipase C activity.

Long-Term Functional Rescue of Trauma-Induced Vision Loss by a Novel, Small Molecule TrkB Activator

This study identifies HIFN, a novel TrkB activator, which improves visual function and retinal neuron survival in a mouse model of ocular trauma.

Roles of Kdm6a and Kdm6b in regulation of mammalian neural regeneration

This study investigates the roles of Kdm6a and Kdm6b in neural regeneration, finding they regulate axon regeneration and RGC survival with distinct mechanisms and identifying Klf4 as a downstream target.

Successful axonal regeneration is driven by evolutionarily conserved metabolic reprogramming

The paper identifies metabolic reprogramming in zebrafish axonal regeneration and shows its conservation in mammals, suggesting therapeutic potential for CNS regeneration.

Context-specific interaction of the lipid regulator DIP-2 with phospholipid synthesis in axon regeneration and maintenance.

The paper investigates the role of lipid metabolism in axon maintenance and regeneration in C. elegans, showing that DIP-2 counterbalances phospholipid synthesis to prevent age-related axonal defects.

Combined Central and Peripheral Nerve Stimulation Improves Functional Recovery of Mixed Peripheral Nerve Injury in a Rat Forelimb Model

This study shows that combining intraoperative electrical stimulation with trigeminal nerve stimulation improves motor recovery in a rat peripheral nerve injury model.

Efficacy of Deferoxamine Mesylate in Serum and Serum-Free Media: Adult Schwann Cell Survival Following Hydrogen Peroxide Induced Cell Death

This study shows that Deferoxamine Mesylate (DFO) enhances Schwann cell survival in serum-containing media but not in serum-free conditions, with increased autophagy and Hif1a expression observed in serum-free environments.

In vivo Morphological Dynamics of Single Laser-Axotomized Corneal Nerve Fibers in Sarm1-Null Adult Mice

This study introduces a novel laser-induced axotomy method in adult mice to study axonal degeneration and regeneration dynamics, revealing delayed degeneration in Sarm1-null mice.

Functional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury

This paper demonstrates that norepinephrine axons in the adult mouse brain can regrow and functionally recover after injury, challenging the belief that adult CNS axons cannot regenerate.

Neuronal activation in the axolotl brain promotes spinal cord regeneration

This study identifies a population of neurons in the axolotl brain that, when activated by tail amputation, promote spinal cord regeneration by stimulating hormone production.

Soleus H-Reflex Up-Conditioning during Sciatic Nerve Regeneration in Rats Improves Recovery of Locomotion

This study shows that H-reflex up-conditioning during sciatic nerve regeneration in rats improves H-reflex recovery and locomotor symmetry, while down-conditioning has no negative effect.

Unexpected Kif4a functions in adult regeneration encompass a dual role in neurons and in proliferative repair Schwann cells.

This paper identifies KIF4A as a dual regulator of axonal regeneration in adult nervous systems, functioning in neurons and proliferative Schwann cells during injury.

Co-delivery of neurotrophic factors and a zinc chelator substantially promotes axon regeneration in the optic nerve crush model

This study co-delivers neurotrophic factors and a zinc chelator using nanoparticles to promote axon regeneration in a rat optic nerve crush model.