Lipid metabolism and biosynthesis

Emergence and evolution of heterocyte glycolipid biosynthesis enabled specialized nitrogen fixation in cyanobacteria

The paper identifies heterocyte glycolipid analogs in non-heterocytous cyanobacteria, suggesting their evolutionary role in enabling nitrogen fixation in heterocytes.

Characterization of Tgl2, a putative lipase in yeast mitochondria

This study characterizes Tgl2, a putative TAG lipase in yeast mitochondria, showing its dimerization, catalytic residues, and role in mitochondrial lipid homeostasis.

Branched chain fatty acid-rich diet promotes lipid droplet enlargement and impacts organismal health in Caenorhabditis elegans

This study shows a BCFA-rich diet in C. elegans causes enlarged lipid droplets, developmental delays, reduced reproduction, and shorter lifespan.

Lipid Droplet Targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosis

This study shows that LD targeting of ABHD5 and PNPLA3 I148M is necessary for their interaction and promotes liver steatosis.

A chemical genomic screen identifies novel genetic interactors of the methylation-dependent de novo pathway of phosphatidylcholine biosynthesis in Saccharomyces cerevisiae.

The paper identifies 410 yeast gene deletion mutants hypersensitive to HEH, revealing 21 genes epistatically interacting with PtdCho methylation pathway enzymes.

Cold induces brain region-selective cell activity-dependent lipid metabolism

This study shows cold exposure increases lipid metabolism in the paraventricular nucleus of the hypothalamus, linking it to cold-induced regulatory responses.

The partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion.

The paper shows that lipid degradation via PDATs limits ER membrane expansion by converting phospholipids into storage lipids in yeast.

Transcriptional regulation of adipocyte lipolysis by IRF2BP2

This study identifies IRF2BP2 as a repressor of adipocyte lipolysis, showing its role in regulating lipolysis-related genes and metabolic homeostasis.

Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase

The paper presents the structure of yeast CPT1 in multiple substrate-bound states to elucidate the mechanism of phospholipid synthesis and selectivity.

Enzymes enabling the biosynthesis of various C20 polyunsaturated fatty acids in a sea urchin Hemicentrotus pulcherrimus

This study identifies genes encoding enzymes involved in the biosynthesis of C20 polyunsaturated fatty acids in the sea urchin Hemicentrotus pulcherrimus.

Exogenous fatty acids inhibit fatty acid synthesis through competition between endogenously- and exogenously-generated substrates for phospholipid synthesis in Escherichia coli

The paper shows exogenous fatty acids inhibit fatty acid synthesis in E. coli by competing with endogenous substrates for phospholipid synthesis enzymes, leading to accumulation of long-chain acyl-ACP and altered membrane lipid balance.

DGTS overproduced in seed plants is excluded from plastid membranes and promotes endomembrane expansion

This study shows that DGTS can be produced in seed plants and accumulates in endomembranes, promoting ER expansion without affecting growth or lipid remodeling.

Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

This study identifies genetic suppressors of PUFA deficiency in C. elegans, showing that increasing PUFA levels, not stress responses, alleviates the defect.

Multiomic analysis of genes related to oil traits in legumes provide insights into lipid metabolism and oil richness in soybean

This study analyzes oil-related gene families across legumes to understand lipid metabolism and oil richness in soybean, identifying gene expansions and expression patterns linked to seed oil content.

New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms

This study investigates ACBD4/5-like proteins across species using phylogenetics and experiments, revealing functional and structural differences in their roles in peroxisome-ER tethering and lipid metabolism.

De novo synthesis of fatty acids in Archaea via an archaeal fatty acid synthase complex

This study shows that archaea can synthesize fatty acids using a newly identified pathway and enzyme complex, providing insights into their evolutionary lipid composition.

VPS28 regulates triglyceride synthesis and is mediated by the ubiquitination pathway in a bovine mammary epithelial cell line and mouse model

The paper investigates the role of VPS28 in triglyceride synthesis through modulation in bovine cells and a mouse model, showing its regulation via the ubiquitination pathway.

AtVPS13M1 is involved in lipid remodeling in low phosphate and is located at the mitochondria surface in plants

This study identifies AtVPS13M1 as a lipid transporter in Arabidopsis thaliana that affects phospholipid degradation during phosphate starvation and localizes to mitochondria.

SREBP governs a triglyceride:glycogen metabolic switch in Drosophila

This paper shows that blocking lipid synthesis in Drosophila fat body triggers a metabolic switch to glycogen storage, mediated by SREBP and HATs, supporting development but reducing lifespan and fecundity.

In-silico study of fatty acid biosynthesis pathway enzymes in microalga Scenedesmus

This study models 3D structures of fatty acid biosynthesis enzymes in Scenedesmus quadricauda and compares them to other species, revealing conserved domains and unique features linked to high lipid accumulation.

The CD36 scavenger receptor Bez regulates lipid redistribution from fat body to oocytes in Drosophila

This paper identifies Bez, a scavenger receptor in Drosophila, as essential for lipid transfer from fat body to oocytes, contributing to reproductive success.

Functional characterization of fatty acid synthase in Hermetia illucens

This study identifies and characterizes a fatty acid synthase gene in Hermetia illucens, elucidating the molecular origin of lauric acid production through in vitro experiments in yeast.

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis

The paper identifies switch mutations in ATGL that selectively disrupt interactions with specific regulatory proteins, linking these mutations to altered lipolysis activity and disease relevance.

Lipidome unsaturation affects the morphology and proteome of the Drosophila eye.

The paper investigates how dietary lipid manipulations affect the Drosophila eye proteome and identifies lipid-responsive proteins involved in muscle function and stress responses.

LipidSIM: inferring mechanistic lipid biosynthesis perturbations from lipidomics with a flexible, low-parameter, systematic Markov Modeling framework

LipidSIM infers lipid biosynthesis perturbations from lipidomics data using a low-parameter Markov model, demonstrating its utility in studying disease-related lipidome changes.

Ultralow background membrane editors for spatiotemporal control of lipid metabolism and signaling

This paper introduces ultralow background membrane editors for PA that use light to control PLD activity, revealing subcellular differences in PA metabolism and signaling.

Identification of Genetic Suppressors for a Berardinelli-Seip Congenital Generalized Lipodystrophy Type 2 (BSCL2) Pathogenic Variant in C. elegans

This study identifies genetic suppressors of a BSCL2 pathogenic variant in C. elegans, revealing potential interactors and pathways involved in seipin function.

A novel adipose loss-of-function mutant in Drosophila

This study identifies a novel adp loss-of-function mutant in Drosophila and shows it does not affect brain growth despite changes in lipid metabolism.

The synaptic vesicle protein Mover/TPRG1L is associated with lipid droplets in astrocytes

The paper identifies Mover/TPRG1L as a lipid droplet protein in astrocytes and shows its role in lipid droplet accumulation and targeting.

Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin

The paper identifies Abhd2 as an enzyme involved in metabolizing phosphatidylcholine and cardiolipin using genetic and lipidomic data from Diversity Outbred mice.