Lipid metabolism and biosynthesis

AD-genes and Aging Increase Count and Size of Lipid Droplets, Accompanied by Accumulation of Neutral Lipids Across Compartments in Hippocampal Neurons.

This study examines lipid polarity and droplet changes in hippocampal neurons across aging and Alzheimer's disease models, finding altered lipid dynamics in AD-transgenic mice.

DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

The paper shows that DDHD2 is essential for neurons to use fatty acids from lipid droplets as an energy source during activity when glucose is unavailable.

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

Lipid droplet dysmetabolism affects cell homeostasis in an in vitro model of Alzheimer disease

The paper investigates lipid droplet (LD) metabolism in an AD model and finds altered LD dynamics contribute to mitochondrial dysfunction and cell dyshomeostasis.

Innovative mutant screening identifies TRANSPARENT TESTA7 as a player in seed oil/protein partitioning

The paper screens an Arabidopsis mutant library to identify genes affecting seed oil and protein partitioning, finding that tt7 mutants show reduced oil content linked to flavonoid pathway changes.

Glucose Starvation Sensing through Membrane Remodeling at theNucleus-Vacuole Junction Coordinates Ergosterol Biosynthesis

This study identifies Nsg1, Nsg2, and Ypf1 as glucose starvation-specific factors at the yeast nucleus-vacuole junction, revealing their role in regulating Hmg1 and Hmg2 through membrane remodeling and sterol biosynthesis.

Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast

This study shows that pentadecanoic acid causes lipotoxicity in fission yeast by forming giant ER sheets, disrupting cell division.

Dynamic changes to the plastoglobule lipidome and proteome in water-deficient maize

This study investigates changes in the plastoglobule lipidome and proteome of water-deficient maize over time, identifying key lipids and proteins involved in adaptive responses to drought.

N-Aldehyde-Modified Phosphatidylethanolamines generated by lipid peroxidation are robust substrates of N-Acyl Phosphatidylethanolamine Phospholipase D

This study identifies N-aldehyde modified phosphatidylethanolamines (NALPEs) as substrates of NAPE-PLD, expanding its known substrate repertoire and suggesting a role in clearing lipid peroxidation products.

Controlling lipid droplet dynamics via tether condensates

This paper introduces ControLD, a method to control lipid droplet dynamics by sequestering and releasing them via engineered condensates, showing that isolation impairs their remobilization during metabolic needs.

Heterologous expression in Saccharomyces and Chlamydomonas reveals host-dependent activity of Brassica juncea fatty acid elongase1 isozymes

This study expresses Brassica juncea FAE1 isozymes in yeast and algae to assess their activity, finding that only yeast supports VLCFA biosynthesis, highlighting host-dependent enzyme function.

Lipid Droplets are active translation depots that respond to infection

This paper shows lipid droplets (LDs) are sites of active protein translation and demonstrate that LD-associated translation is regulated during Mycobacterium tuberculosis infection.

Pln1 Mediates Lipid Droplet-Vacuole Tethering During Microlipophagy Saccharomyces cerevisiae

This study identifies Pln1 as a mediator of lipid droplet-vacuole tethering during microlipophagy in Saccharomyces cerevisiae, revealing its role in LD degradation and survival under starvation.

Unraveling the Molecular Mechanisms of ABHD5 Membrane Targeting

This study identifies a dual-site membrane recognition mechanism in ABHD5 that enables its activation and regulation of lipid metabolism.

The Drosophila Estrogen-Related Receptor promotes triglyceride storage within the larval fat body

This study investigates the role of dERR in regulating lipid metabolism in Drosophila larval fat body, showing it promotes TAG accumulation and interacts with dHNF4.

Widespread discordance between mRNA expression, protein abundance and de novo lipogenesis activity in hepatocytes during the fed-starvation transition

The paper examines mRNA, protein, and lipogenesis activity in hepatocytes during feeding and starvation, finding widespread discordance between mRNA and protein levels, especially in sex-biased genes and lipogenic pathways.

Perilipin 5 Phosphorylation is Dispensable for Upregulation of Hepatic Lipid Metabolism Genes upon Fasting but Required for Insulin Receptor Substrate 2 Expression in Male Mice

This study investigates the role of PLIN5 phosphorylation in mice, finding it dispensable for lipid metabolism gene upregulation during fasting but necessary for IRS2 expression in males.

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Excitation Spectral Phasor Microscopy (ExSPM) unveils spatiotemporal heterogeneities in polarity of intracellular lipid droplets

ExSPM reveals spatiotemporal heterogeneities in lipid droplet polarity, showing dynamics and pathway-specific kinetics of lipid metabolism.

Persistent fatty acid catabolism during plant oil synthesis

The paper shows that fatty acid synthesis and breakdown occur simultaneously during plant oil synthesis, challenging previous assumptions and explaining underperformance in engineered oil-producing plants.

Dynamic Lipidome Reorganization in Response to Heat Shock Stress

This study investigates lipidomic and transcriptomic changes in HeLa cells under heat shock and recovery, revealing extensive lipid remodeling and transcriptional regulation.

An inducible and reversible system to regulate unsaturated fatty acid biosynthesis in C. elegans

The paper develops a system to reversibly control UFA biosynthesis in C. elegans by targeting fat-7 while deleting fat-5 and fat-6, revealing its essential role in early development and lipid metabolism.

Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes

This study shows that PDK1 regulates triacylglycerol turnover in cardiomyocytes under nutrient deprivation, independent of its role in glucose metabolism.

A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis

This study shows that the EMC3 subunit is critical for lipid droplet homeostasis in mice and Drosophila, with loss of EMC3 causing triglyceride storage defects and reduced FITM2 levels.

Knockout of fatty acid elongase1 homeoalleles in amphidiploid Brassica juncea leads to undetectable erucic acid in seed oil

This study uses CRISPR/Cas9 to knockout FAE1 genes in Brassica juncea, reducing erucic acid and increasing beneficial fatty acids without compromising yield.

Laboratory yeast strains are highly diverse in lipid metabolism

This study compares lipidomes of five yeast strains, finding significant differences in lipid classes and molecular species, with transcriptomic data suggesting post-transcriptional regulation.

Hoi1 targets the yeast BLTP2 protein to ER-PM contact sites to regulate lipid homeostasis

This study identifies Hoi1 as an adaptor that targets BLTP2-like proteins to ER-PM contact sites in yeast, regulating lipid homeostasis and showing conservation in worms and flies.

Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation

The paper shows ketogenesis supports PUFA homeostasis in hepatocytes by enabling FA elongation, and its disruption leads to lipid imbalances similar to MASLD.

SEPSIS-INDUCED LIPID DROPLET ACCUMULATION ENHANCES ANTIBACTERIAL INNATE IMMUNITY

This study shows that lipid droplet accumulation during sepsis enhances antibacterial innate immunity by promoting bacterial clearance and pro-inflammatory responses through DGAT1-dependent mechanisms.

Knocking out the carboxyltransferase interactor 1 (CTI1) in Chlamydomonas boosted oil content by fivefold without affecting cell growth