Axon Guidance and Neuronal Signaling

TRIC Coupled with TR-FRET as a High-Throughput Screening Platform for the Discovery of SLIT2 Binders: A Proof-of-Concept Approach

This paper presents a high-throughput screening platform combining TRIC and TR-FRET to identify SLIT2 binders, finding bexarotene as a potent inhibitor with a KD of 2.62 μM.

Plexin/Semaphorin Antagonism Orchestrates Collective Cell Migration, Gap Closure and Organ sculpting by Contact-Mesenchymalization

The paper identifies a contact-dependent mechanism involving Plexin A and Semaphorin 1B that drives gap closure and organ sculpting during collective cell migration in Drosophila.

Structural insights into wiring specificity in the neuromuscular system through the Beat-Side complex

The paper reports the first structure of the Beat-Side complex and shows its role in motor neuron connectivity in Drosophila.

Commissureless acts as a substrate adapter in a conserved Nedd4 E3 ubiquitin ligase pathway to promote axon growth across the midline

This study identifies Commissureless as a substrate adapter for the Nedd4 E3 ubiquitin ligase, promoting axon growth across the midline by facilitating Robo1 ubiquitination and degradation.

Region-specific Brain Targets Drive Circuit Formation and Maturation of Human Retinal Ganglion Cells

This paper develops an in vitro model to study human retinal ganglion cell (RGC) connectivity with specific brain regions, showing that cultured RGCs form region-specific synapses with mouse brain targets.

Lrrns define a visual circuit underlying brightness and contrast perception

The paper identifies a brightness and contrast processing circuit in zebrafish and shows Lrrn CAMs are essential for its assembly and function.

Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit

The paper shows that dimensionality reduction simplifies synaptic partner matching in the fly antennal lobe by reducing a 3D search problem to a 1D trajectory.

Sperrfy the brain: A data-driven realization of Sperry's Chemoaffinity theory in the neural connectome

SPERRFY applies Sperry's chemoaffinity theory to whole-brain connectivity using spatial transcriptomics and connectomic data, revealing positional gradients that predict axonal wiring with high accuracy.

ISLET-1 knockdown causes abnormal peripheral axonal growth of mesencephalic trigeminal neurones in the chick embryo

This study investigates the role of Islet-1 in axon guidance of mesencephalic trigeminal neurons in chick embryos, finding that its knockdown affects peripheral axonal growth but not central axonal direction.

'Mitotic' kinesin-5 is a dynamic brake for axonal growth

This study shows that kinesin-5 acts as a brake on axonal growth by regulating microtubule sliding in Drosophila neurons.

Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion

This paper shows that Mef2c regulates the development of cortical neurons and their postnatal axon targeting by modulating EphA6 expression and sensitivity to EphrinA5 repulsion.

FRAZZLED/DCC REGULATES GAP JUNCTION FORMATION AT A DROSOPHILA GIANT SYNAPSE THROUGH TRANSCRIPTION

This study shows Frazzled/DCC regulates gap junction formation in Drosophila Giant Fiber System through transcriptional control of synaptic components.

The PVD neuron has male-specific structure and mating function in C. elegans

The paper identifies a male-specific structure and mating function of the PVD neuron in C. elegans, showing its unique extension into the copulatory tail and behavioral role in mating.

A central role for Numb/Nbl in multiple Shh-mediated axon repulsion processes

This study shows Numb is required for Shh-mediated repulsion of retinal ganglion cell and spinal commissural axons, highlighting its role in both attraction and repulsion processes.

Mistargeted retinal axons induce a synaptically independent subcircuit in the visual thalamus of albino mice.

The paper shows that mistargeted retinal axons in albino and EphB1 knockout mice form synaptically isolated subcircuits in the visual thalamus.

Computation model predicts Rho GTPase function with the Plexin Transmembrane receptor GAP activity on Rap1b via dynamic allosteric changes

The paper uses molecular dynamics simulations to analyze conformational changes in Plexin-B1 bound to Rap1b, Rnd1, and Rac1, revealing differences in dynamics and interactions.

Cholesterol inhibits oncogenic EphA2 activation

This study shows that cholesterol inhibits EphA2 self-assembly and oncogenic signaling by preventing its activation through an in-trans mechanism involving protein kinase A.

Isl1 Controls Axon Pathfinding of Retinal Ganglion Cells in the Binocular Visual Pathway

The paper shows that ISL1 regulates retinal ganglion cell (RGC) laterality, affecting axon pathfinding and ipsilateral projections, with downstream effectors and some shared mechanisms with ZIC2.

Novel function of Contactin associated protein 1 (Caspr 1)/ Paranodin in embryonic cortical neurons: hypoxia modulated neurite development.

This study investigates how hypoxia affects neurite development in mouse embryonic cortical neurons, revealing a dynamic role for Caspr1 in compensating for hypoxic stress.

Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins

The paper shows that altering a combination of cell-surface proteins in Drosophila olfactory neurons can switch their synaptic connections to different projection neuron types, revealing a combinatorial code for circuit assembly.

Repulsive interactions instruct synaptic partner matching in an olfactory circuit

The paper identifies three CSP pairs mediating repulsive interactions that prevent non-cognate synaptic connections in Drosophila olfactory circuits.

A teneurin-3 microphthalmia mutation disrupts trans adhesion for specific alternative splicing isoforms

The paper shows that a mutation in teneurin-3 disrupts trans adhesion specifically in splice isoforms containing insert A, contributing to microphthalmia.

Neurons exploit stochastic growth to rapidly and economically build dense radially oriented dendritic arbors

The paper develops a mean-field model showing stochastic growth can create complex dendritic arbors without external guidance.

A Critical Role for the Fascin Family of Actin Bundling Proteins in Axon Development, Brain Wiring and Function

This study shows that fascin is essential for axon development, brain wiring, and function in both cultured neurons and Drosophila melanogaster.

Glutamate and early functional NMDA Receptors promote axonal elongation modulating both actin cytoskeleton dynamics and H2O2 production dependent on Rac1 activity

Centrosome Loss Alters Axonal and Muscle Development

This study shows that centrosome loss in Drosophila affects axonal routing and muscle organization during development.

Short- and long-range roles of UNC-6/Netrin in dorsal-ventral axon guidance in vivo in Caenorhabditis elegans

This study investigates the short- and long-range roles of UNC-6/Netrin in dorsal-ventral axon guidance in C. elegans, showing that UNC-6 acts as a permissive cue rather than an instructive one.

Prolyl isomerase FKBP12 reduces axon growth and negatively regulates microtubule polymerization by inhibiting CRMP2A

This paper shows FKBP12 inhibits CRMP2A-mediated microtubule polymerization and axon growth by binding to unphosphorylated CRMP2A.

Cytoneme-mediated signalling coordinates the development of glial cells and neurons in the Drosophila eye

This study shows that cytoneme-mediated Hedgehog signaling coordinates glial and neuronal development in the Drosophila eye.

Point contact-restricted cAMP signaling controls ephrin-A5-induced axon repulsion

This study shows that point contact-restricted cAMP signals modulate ephrin-A5-induced axon repulsion by controlling Focal Adhesion Kinase phosphorylation and point contact dynamics.