C. Yang

The protein phosphatase PPKL is a key regulator of daughter parasite development in Toxoplasma gondii

This study identifies PPKL as a critical phosphatase for daughter parasite development in Toxoplasma gondii, showing its role in regulating cortical microtubules and the Crk1-dependent signaling pathway.

A Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis

This study identifies GLP-1(32-36) as a therapeutic agent that rescues diabetic ischemic lower limbs by enhancing glycolysis and EPC function via GLP-1R-dependent mechanisms.

A Quadrivalent mRNA immunization elicits potent immune responses against vaccinia and monkeypox viral antigens - a step closer to a broad orthopoxvirus vaccine

This study develops an mRNA vaccine encoding four vaccinia antigens that induces strong immune responses against vaccinia and monkeypox viruses, suggesting broad orthopoxvirus protection.

Enhancer evolution as a driving force for lineage-specific paralog usage in the central nervous system.

The paper investigates how enhancer evolution drives lineage-specific paralog usage in hypophysiotropic GnRH neurons across vertebrates, finding that enhancer loss, not regulatory changes, caused paralog role division.

Integrin beta4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound

This paper characterizes mitotic phenotypes caused by a MYC synthetic lethal compound, dimethylfasudil, showing cell cycle arrest, mitotic catastrophe, and segregation anomalies.

High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by systematic metabolic engineering

This study engineered Yarrowia lipolytica to overproduce nervonic acid through metabolic pathway modifications, achieving high titers and purity.

Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

The paper shows that multiple cancer types rapidly escape MAPK inhibitors by forming mutagenesis-prone subpopulations through ATR and FA pathway dependencies.

Epithelial galectin-3 induces mitochondrial complex inhibition and cell cycle arrest of CD8+ T Cells in severe/critical ill COVID-19

This study identifies galectin-3 as a factor that inhibits mitochondrial function and causes cell cycle arrest in CD8+ T cells of severe/critical COVID-19 patients, with potential therapeutic implications.

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

ABI5-FLZ13 Module Transcriptionally Represses Growth-related Genes to Delay Seed Germination in Response to ABA

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

Metabolic responses of normal rat kidneys to a high salt intake.

This study examines how normal rat kidneys respond metabolically to a high salt diet, showing increased glycolysis and oxygen consumption despite reduced TCA cycle enzyme expression.

CXCL4 signaling and gene induction in human monocytes

This study investigates CXCL4 signaling in human monocytes, identifying NF-κB and TBK1-JNK pathways and a potential role for TLR4, while noting challenges in isolating CXCL4's effects from endotoxin contamination.

Regulation of interstitial fluid flow along adventitia of vasculature by heartbeat and respiration

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

Field dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging

This paper introduces FD-DeepLoc, a deep learning method for high-throughput 3D super-resolution imaging over a large field of view using a sCMOS camera.

ATM-Mediated Double-Strand Break Repair Is Required for Meiotic Genome Stability at High Temperature

This study shows ATM is essential for maintaining meiotic genome stability in Arabidopsis at high temperatures, acting through the MRN complex and chromosome axis, independent of RAD51.

Highly Sensitive and Specific Amyloid-β Oligomers Detection Using CRISPR-Cas12a Probe System aided by Graphene Oxide for Early Diagnosis of Alzheimer's Diseases

This study develops a CRISPR-Cas12a-based sensor enhanced with graphene oxide for specific and sensitive detection of amyloid-β oligomers, aiming to enable early Alzheimer's disease diagnosis.

Genome-scale mRNA transcriptomic insights into the mature growth dynamic of Cigar tobacco leaves

This study uses transcriptomic analysis to examine gene expression changes in cigar leaves at different growth stages, identifying key pathways and regulatory networks associated with maturity.

Physiological state matching in a pair bonded poison frog

The paper investigates emotional contagion in poison frogs, finding physiological state-matching between male and female partners, independent of behavioral or reproductive factors.

Targeting caveolae to pump bispecific antibody to TGF-β into diseased lungs enables ultra-low dose therapeutic efficacy

This paper develops a bispecific antibody that targets caveolae to deliver TGF-β inhibitors specifically to lungs, achieving ultra-low dose therapeutic efficacy in a rat model.

HPV E6 upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer

Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells

This paper shows that inhibiting PARP7 with RBN2397 reduces prostate cancer cell growth through multiple mechanisms, including trapping PARP7 in the nucleus and affecting gene expression.

Rates but not acoustic features of ultrasonic vocalizations are related to non-vocal behaviors in mouse pups

This study finds that non-vocal behaviors, particularly active movements, correlate with the rate but not the acoustic features of isolation ultrasonic vocalizations in mouse pups.

Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

Helicobacter chronic stage inflammation undergoes fluctuations that are altered in tlpA mutants

This study shows that H. pylori chronic inflammation fluctuates over time, and tlpA mutants alter these dynamics without affecting colonization levels in later stages.

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

Wireless Neuromodulation at Submillimeter Precision via a Microwave Split-Ring Resonator

This paper introduces a microwave split-ring resonator that enables submillimeter precision neuromodulation by enhancing microwave field localization and efficiency for inhibiting neurons.

Label-Free Hyperspectral Imaging and Deep-Learning Prediction of Retinal Amyloid β-Protein and Phosphorylated Tau

This paper develops a label-free hyperspectral imaging method combined with deep learning to detect and predict retinal amyloid β-protein and phosphorylated tau in Alzheimer's disease.

DINAVID: A Distributed and Networked Image Analysis System for Volumetric Image Data

DINAVID provides a cloud-based system for remote 3D microscopy image analysis and visualization, designed to handle large datasets and improve accessibility.