C. Yang

Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic Remodeling

This study shows CXCL4 enhances TLR8 responses in human monocytes by promoting inflammatory gene transcription and IL-1β production through TBK1-IRF5 signaling and chromatin remodeling.

Bipartite recruitment of PCH2 and COMET to the synaptonemal complex drives chromosome axis reconstruction leading to crossover restriction

This study shows that PCH2 and COMET are recruited to the synaptonemal complex via ZYP1 to regulate ASY1 removal and crossover restriction during meiosis.

The Arabidopsis Hop1 homolog ASY1 mediates cross-over assurance and interference

This study investigates the role of ASY1 in meiotic crossover (CO) assurance and interference in Arabidopsis, showing that reduced ASY1 activity leads to altered CO distribution and genomic instability.

Engineering ecologically complementary rhizosphere probiotics using consortia of specialized bacterial mutants

This study improves plant growth-promotion by engineering specialized bacterial mutants within a single species and assembling them into consortia that enhance root colonization and disease resistance.

High Cellular Uptake Gene Delivery Platform with Chitosan and L-arginine Complex for Cancer Treatment

This study develops a chitosan-L-arginine complex for gene delivery, showing high encapsulation efficiency and enhanced cellular uptake of siRNA in cancer cells.

Slow-cycling cells in glioblastoma: a specific population in the cellular mosaic of cancer stem cells

This study compares slow-cycling cells with cancer stem cell (CSC)-like cells in glioblastoma, showing phenotypic and functional heterogeneity and supporting the cancer stem cell mosaicism model.

The tyrosine phosphatase PRL regulates attachment of Toxoplasma gondii to host cells and is essential for virulence

This paper identifies TgPRL as a critical tyrosine phosphatase in Toxoplasma gondii that regulates attachment to host cells and virulence, with implications for therapeutic intervention.

Conserved Untranslated Regions of Multipartite Viruses: Natural Markers of Novel Viral Genomic Components and Tags of Viral Evolution

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.

The anti-angiogenic compound dimethyl fumarate inhibits the serine synthesis pathway and increases glycolysis in endothelial cells

This study shows dimethyl fumarate inhibits serine synthesis and increases glycolysis in endothelial cells, potentially explaining its anti-angiogenic effects.

Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.

Optogenetic operated probiotics to regulate host metabolism by mimicking enteroendocrine

The paper develops an optogenetic probiotics system to control enteroendocrine hormone secretion in vivo, demonstrating improved glucose control in animal models.

Defining Innate Immune Responses to the Human Gut Microbiota from Phylum to Strain

This study screens 277 gut bacterial strains to define innate immune responses, showing strain-specific and phylum-level variations in immune activation.

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis

This study shows that G6PD deficiency in melanoma cells increases oxidative stress and glutaminolysis, reducing metastasis by making cells more vulnerable to metabolic disruption.

Assessing and enhancing foldability in designed proteins

This study develops methods to assess and improve foldability in designed proteins, significantly enhancing catalytic efficiency and stability.

Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy

This study shows TRPV4 activation contributes to pressure overload-induced cardiac hypertrophy through Ca2+/CaMKII-mediated NFκB-NLRP3 activation, suggesting TRPV4 as a therapeutic target.

A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

Amplicon sequencing of single-copy protein-coding genes reveals accurate diversity for sequence-discrete microbiome populations

This paper develops a pipeline to identify single-copy protein-coding genes for accurately quantifying sequence-discrete populations in microbial communities, validated using Gilliamella in honeybee guts.

Alkyne modified purines for assessing activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.

This study develops alkyne-modified purines as a DNA synthesis marker to distinguish replicating and non-replicating Plasmodium stages, aiding in understanding dormancy mechanisms.

Progressive protein aggregation in PRPF31 patient retinal pigment epithelium cells: the mechanism and its reversal through activation of autophagy

This study shows that PRPF31 mutations cause progressive protein aggregation in RPE cells, which can be reversed by autophagy activation.

A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated super-enhancers

This study shows YY1 forms phase-separated super-enhancers by compartmentalizing coactivators and enhancer elements, with a histidine cluster essential for this process.

Cerebrospinal fluid outflow through skull channels instructs cranial hematopoiesis

The paper shows cerebrospinal fluid exits through skull channels into bone marrow, and bacteria use this route during meningitis to initiate cranial hematopoiesis.

Self-assembly of pericentriolar material in interphase cells lacking centrioles

This study shows that PCM can self-assemble into a compact MTOC in interphase cells without centrioles, using dynein transport and self-clustering, but this process is sensitive to motor and microtubule dynamics.

The tetrameric assembly of 2-aminomuconic acid dehydrogenase is a functional requirement of cofactor NAD+ binding

This paper identifies the tetrameric assembly of AmnC as essential for NAD+ binding and enzymatic activity in 2-aminophenol metabolism.

Image-based assessment of plant disease progression identifies new genetic loci for resistance

The paper uses image-based phenotyping to identify new genetic loci for disease resistance in tomato plants, detecting QTL earlier and more accurately than human assessment.

Structural insight into molecular inhibitory mechanism of InsP6 on African Swine Fever Virus mRNA-decapping enzyme g5Rp

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

Artemisinin-based hybrids produce intracellular proteasome inhibitors that overcome resistance in Plasmodium falciparum

This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.

Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function

This study reconstitutes the DTX3L-PARP9 complex to identify determinants for high-affinity heterodimer formation and enzymatic function.

Endogenous RNA editing of a nuclear gene BOSS triggers flowering in tomato

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progression

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

SOD2 in Skeletal Muscle: New Insights from an Inducible Deletion Model

This study deletes SOD2 in skeletal muscle of adult mice and finds no major metabolic impairment but altered lipid metabolism and mitochondrial abundance.