D. Wang

The gravitation-driven stress-reduced urothelial barrier in toad bladder urothelium

The paper investigates how gravitation stress affects the transmembrane potential in toad bladder urothelium, showing increased chloride channel activity and altered ion permeability.

Targeting a proteolytic neo-epitope of CUB-domain containing protein 1 in RAS-driven cancer

The paper develops antibodies targeting proteolytic neo-epitopes of CDCP1 in RAS-driven cancers, showing improved tumor specificity and safety.

Megakaryocyte derived immune-stimulating cells regulate host-defense immunity against bacterial pathogens

The paper identifies MK-derived immune-stimulating cells (MDICs) that enhance host defense against bacterial infections by interacting with myeloid cells and producing cytokines.

Discovery, diversity and functional associations of crAss-like phages in human gut metagenomes from four Dutch cohorts

The paper discovers new crAss-like phage species and explores their diversity, genomic features, host associations, and links to human health phenotypes in Dutch gut metagenomes.

Fitness costs of female choosiness in a socially monogamous songbird

The study examines the fitness costs of female mate choice in zebra finches, finding that high competition does not reduce fitness due to alternative reproductive tactics.

A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope

The paper identifies an antibody that neutralizes all SARS-CoV-2 variants by targeting a conserved epitope on the spike protein.

Variations in soil nutrient dynamics and bacterial communities in long-term tea monoculture production systems

This study examines how long-term tea monoculture affects soil nutrient dynamics and bacterial communities across different stand ages.

Decreased biofilm formation in Proteus mirabilis after short-term exposure to a simulated microgravity environment

This study examines how simulated microgravity affects biofilm formation in Proteus mirabilis and identifies gene expression changes linked to reduced biofilm formation.

Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in Myc-driven Medulloblastoma

This study identifies CDK7 as a therapeutic target in Myc-driven medulloblastoma, showing that its inhibition sensitizes tumors to radiation.

Structural basis for HCMV Pentamer recognition by antibodies and neuropilin 2

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

Two interacting transcriptional coactivators cooperatively control plant immune responses

This study identifies NPR1 and EDS1 as interacting coactivators that synergistically activate PR genes and plant defenses through Mediator complex recruitment and mutual stabilization.

Destruction of DNA-binding proteins by programmable O'PROTAC: Oligonucleotide-based PROTAC

This paper develops OPROTACs, programmable molecules that degrade DNA-binding proteins like ERG and LEF1, showing potential for targeting undruggable transcription factors in cancer.

Molecular mechanism regulating transcriptional control of the hig toxin-antitoxin locus of antibiotic-resistance plasmid Rts1 from Proteus vulgaris

This paper investigates the regulation of the HigBHigA toxin-antitoxin pair from plasmid Rts1 in Proteus vulgaris, finding it functions as an on/off transcriptional switch rather than a molecular rheostat.

T-cell Repertoire Characteristics of Asymptomatic and Re-detectable Positive COVID-19 Patients

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

Gut microbial structural variations as determinants of human bile acid metabolism

The paper identifies bacterial structural variants associated with bile acid metabolism in humans using metagenomic data from two Dutch cohorts.

High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate theprogression of pancreatic cancer

Pilot study: Trehalose-induced remodelling of the human microbiota affects Clostridioides difficile infection outcome in an in vitro colonic model

This study shows that trehalose supplementation remodels the human gut microbiota, preventing simulated Clostridioides difficile infection in an in vitro model.

Machine learning reveals cryptic dialects that guide mate choice in a songbird

This study uses machine learning to uncover hidden song dialects in zebra finches that influence mate choice, showing cultural transmission drives assortative mating.

Th17 immunity in the colon is controlled by two novel subsets of colon-specific mononuclear phagocytes

This study identifies two novel colon-specific mononuclear phagocyte subsets that are critical for Th17 immunity in the colon.

Membrane contact probability: an essential and predictive character for the structural and functional studies of membrane proteins

The paper introduces membrane contact probability (MCP) as a predictive metric for membrane proteins, showing it improves contact map and structure predictions.

Combined Enhanced Biological Phosphorus Removal (EBPR) and Nitrite Accumulation for Treating High-strength Wastewater

This study combines enhanced biological phosphorus removal with nitrite accumulation in a reactor treating synthetic digested manure wastewater, achieving high phosphorus removal and stable nitrite levels.

Isothermal Amplification of Nucleic Acids with Ladder-shape Melting Curve

The paper develops a novel isothermal amplification method (LMCP) for detecting Oryza sativa ITS with higher sensitivity and speed compared to LAMP.

Generation of a SARS-CoV-2 Replicon as a Model System to Dissect Virus Replication and Antiviral Inhibition

The paper develops a non-infectious SARS-CoV-2 replicon system to study viral replication and test antiviral compounds, revealing cell-line-specific inhibitor potencies.

Quantitatively Monitoring in situ Mitochondrial Thermal Dynamics by Upconversion Nanoparticles

This study develops upconversion nanoparticles to monitor mitochondrial temperature dynamics in living cells and shows distinct thermal responses to various stimuli.

Continuous cis-regulatory changes in an advantageous gene are linked with adaptive radiation in cichlid fishes

The paper identifies cis-regulatory changes in a gene linked to adaptive radiation in cichlid fishes by showing their impact on gene expression patterns across lineages.

Modeling Versatile and Dynamic Anaerobic Metabolism for PAOs/GAOs Competition Using Agent-based Model and Verification via Single Cell Raman Micro-spectroscopy

This study develops and validates an improved EBPR model (iEBPR) to simulate PAO-GAO competition under extended anaerobic conditions using single-cell Raman micro-spectroscopy data.

CPEB2 m6A Methylation Regulates BTB Permeability via Affecting Splicing Factor SRSF5 Stability

This study identifies a regulatory pathway involving CPEB2 m6A methylation that affects BTB permeability through SRSF5 and P51-ETS1, enhancing drug efficacy in glioma treatment.

Allantoin induces pruritus by activating MrgprD in chronic kidney disease

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

Efficient long-range conduction in cable bacteria through nickel protein wires

This study identifies nickel-ligated proteins as the conductive core of cable bacteria's periplasmic wires, revealing a novel mechanism for long-range electron transport.

Fast 3D printing of large-scale biocompatible hydrogel models

This paper introduces a fast 3D printing method called FLOAT to create large-scale biocompatible hydrogel models with minimal deformation and cellular injury.