D. Wang

Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

Auxin guides germ cell specification in Arabidopsis anthers

This study shows auxin guides germ cell specification in Arabidopsis anthers by creating a centripetal gradient that is essential for GC initiation and patterning.

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

This study shows that inhibiting SHP2 in endothelial cells reduces tumor growth by damaging the tumor vasculature, independent of SHP2 effects in tumor cells.

Control of ss-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence

This study shows that Eng1 and Ywp1 in C. albicans reduce Dectin-1 binding by masking β-glucans, thereby decreasing immune recognition and virulence.

mRNA translation control by Dhx36 binding to 5' UTR G-quadruplex structures is essential for skeletal muscle stem cell regenerative functions

This study identifies Dhx36 as essential for skeletal muscle stem cell regeneration by regulating mRNA translation through binding and unwinding 5' UTR G-quadruplex structures.

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

MicroRNA-224 Promotes Cell Migration and Invasion by Targeting HOXA5 expression in Hepatocellular Carcinoma

This study shows miR-224 promotes HCC cell migration and invasion by targeting HOXA5 and ADAM17, suggesting it as a potential therapeutic target.

A targetable epigenetic vulnerability in PI3K/AKT inhibitor resistant cancers

This study identifies an epigenetic vulnerability in PI3K/AKT inhibitor-resistant cancers, showing that targeting bromodomain or HDAC inhibitors can overcome resistance by modulating histone acetylation at growth factor/receptor gene loci.

Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway

A genomic link in China roses: and they all lived prickly but water deficient ever after?

The paper identifies genetic elements and QTL associated with stem prickle development in roses, linking prickle density to water-related adaptations.

Enabling in vivo Analysis Via Nanoparticle-mediated Intracellular Assay Probe Delivery: Using RAS as the Prototype

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

Evolution of a sex megachromosome

The paper investigates the evolution of a sex megachromosome in cichlid fish, finding it consists of three distinct regions and contains unique genomic features.

PacC-dependent adaptation and modulation of host cellular pH controls hemibiotrophic invasive growth and disease development by the rice blast fungus

This study identifies the PacC-dependent pH signaling pathway in the rice blast fungus Magnaporthe oryzae, showing it regulates host pH changes and the switch between biotrophic and necrotrophic growth, essential for disease development.

Rapid detection of SARS-CoV-2 and other respiratory viruses by using LAMP method with Nanopore Flongle workflow

This paper describes a rapid method using LAMP and Nanopore Flongle for detecting SARS-CoV-2 and other respiratory viruses in under two hours.

Tomato fruit susceptibility to fungal disease can be uncoupled from ripening by suppressing susceptibility factors

This study identifies pectate lyase (PL) as a susceptibility factor in tomato fruit ripening, showing that suppressing PL reduces fungal disease susceptibility without affecting defense responses.

Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.

This study develops two neutralization assays for SARS-CoV-2 using VSV and a clinical isolate, showing high concordance between monoclonal, polyclonal antibodies, and ACE2-Fc in neutralizing activity.

A Chemical-genetics and Nanoparticle Enabled Approach for in vivo Protein Kinase Analysis

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

Hypoxia driven oncometabolite L-2HG maintains "stemness"-differentiation balance and facilitates immune suppression in pancreatic cancer

This study shows hypoxia drives L-2HG production in pancreatic tumors, maintaining stemness-differentiation balance and promoting immune suppression, with LDH inhibition reversing these effects.

Endophilin A1 promotes Actin Polymerization in response to Ca2+/calmodulin to Initiate Structural Plasticity of Dendritic Spines

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

A statistical framework for assessing pharmacological response and biomarkers using uncertainty estimates

The paper introduces a statistical framework using uncertainty estimates to identify biomarkers from drug screening data, finding 24 known and 6 novel biomarkers in cancer cell lines.

Sphingosine-1-phosphate receptors 1 and 3 regulate the expression of SR-B1 in human aortic endothelial cells

This study shows that S1PR1 and S1PR3 regulate SR-B1 expression in human aortic endothelial cells through transcriptional and post-translational mechanisms.

Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma

This study identifies allosteric HSP70 inhibitors that overcome proteasome inhibitor resistance in multiple myeloma by targeting mitochondrial HSPA9 and disrupting mitoribosome stability.

Proteomics of protein trafficking by in vivo tissue-specific labeling

The paper develops an in vivo platform to study secreted protein trafficking between organs, identifies interorgan communication factors, and finds conserved adipokines affecting muscle activity.

Selective role of Nck1 in atherogenic inflammation and plaque formation

This study identifies Nck1's role in flow-induced endothelial activation and atherosclerosis by showing its necessity for IRAK-1 activation and inflammation.

Clinical Characteristics and Risk of Second Primary Lung Cancer After Cervix Cancer: A Population-Based Study

This study compares clinical characteristics and prognosis of second primary non-small cell lung cancer after cervical cancer with first primary non-small cell lung cancer using SEER data.

SARS-CoV-2 proteome microarray for mapping COVID-19 antibody interactions at amino acid resolution

This paper develops a SARS-CoV-2 proteome microarray to analyze antibody interactions at amino acid resolution and identifies epitopes and neutralizing antibodies in COVID-19 patients.

Multiband entropy-based feature-extraction method for automatic identification of epileptic focus based on high- frequency components in interictal iEEG

This paper develops a machine learning method using entropy features from high-frequency iEEG subbands to accurately identify epileptic focus in patients.

Facing small and biased data dilemma in drug discovery with federated learning

This paper applies federated learning to drug discovery, showing it improves prediction accuracy over centralized training with biased and small datasets.

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs

The paper constructs an adult human cell atlas from 84,363 cells across 15 organs, identifying 252 cell subtypes and revealing inter- and intra-organ heterogeneity.

Evolutionary and functional genomics of DNA methylation in maize domestication and improvement

This study investigates DNA methylation variation during maize domestication using WGS and WGBS, identifying DMRs linked to gene regulation and adaptation.