D. Yu

Case Study of Single-cell Protein Activity Based Drug Prediction for Precision Treatment of Cholangiocarcinoma

The paper develops a single-cell framework to prioritize drugs for cholangiocarcinoma by analyzing subpopulations and validating predictions in patient-derived xenografts.

A cooperative switch within the KaiC hexamer revealed by cryo-EM

The paper uses cryo-EM to reveal cooperative conformational changes in KaiC hexamers that enable switch-like phosphorylation responses.

TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death

A novel mechanism of Euonymine inhibits in-stent restenosis through enhancing contractile phenotype of VSMCs by targeting AKT1 and p38MAPK

Novel torin1-sensitive phosphorylation sites on the metabolic regulator AMPK revealed by label-free mass spectrometry

The paper identifies mTORC1-sensitive phosphorylation sites on AMPK using mass spectrometry, revealing their role in regulating nuclear AMPK activity and cell proliferation under nutrient stress.

Amplification-free detection of viral RNA by super resolution imaging-based CRISPR/Cas13a System

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

AGL16 regulates genome-wide gene expression and flowering time with partial dependency on SOC1 in Arabidopsis

This study identifies AGL16's role in regulating gene expression and flowering time in Arabidopsis, showing partial dependency on SOC1 and involvement in water loss and seed dormancy.

A non-coding A-to-T Kozak site change related to the transmissibility of Alpha, Delta and Omicron VOCs

This study identifies two non-coding A-to-T mutations at the Kozak site of the N gene as potentially contributing to the transmissibility of Alpha, Delta, and Omicron SARS-CoV-2 variants.

Chemoproteomic study uncovers HemK2/KMT9 as a new target for NTMT1 bisubstrate inhibitors

The paper identifies HemK2/KMT9 as a new target of NTMT1 bisubstrate inhibitor NAH-C3-GPKK through chemoproteomic profiling.

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

EZH2 Engages TGFβ Signaling to Promote Breast Cancer Bone Metastasis via Integrin β1-FAK Activation

This study identifies EZH2's role in promoting breast cancer bone metastasis through the integrin β1-FAK pathway and TGFβ signaling.

A traditional medicine, Respiratory Detox Shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the Influenza A virus in vitro

The human cytomegalovirus UL116 glycoprotein is a chaperone to control gH-based complexes levels on virions

This study shows that UL116 acts as a chaperone for gH, regulating the levels of gH-based complexes in HCMV virions and affecting infectivity.

The human cytomegalovirus protein UL116 interacts with the viral ER resident glycoprotein UL148 and promotes the incorporation of gH/gL complexes into virions

This study identifies UL116 as a chaperone for gH that promotes gH/gL complex expression and virion incorporation, interacting with UL148 to support viral entry mechanisms.

Biochemical Validation of a Fourth Guanidine Riboswitch Class in Bacteria

The paper identifies and validates a fourth guanidine riboswitch class in bacteria, demonstrating its novel aptamer and expression platform for ligand-dependent gene activation.

Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity

This study identifies SARS-CoV-2's high fusogenic activity via ACE2 receptor and designs a potent lipopeptide inhibitor, IPB02, targeting the HR2 region of the spike protein.

The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and insights into Kex2 protease processing of fungal effectors

The paper determines the crystal structure of SnTox3, a fungal effector, revealing a novel β-barrel fold and showing that it is a pre-pro-protein processed by Kex2 protease.

METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes

This study identifies METTL5 as an 18S rRNA-specific m6A methyltransferase that modulates stress response gene expression by affecting translation.

Cross-reactive neutralization of SARS-CoV-2 by serum antibodies from recovered SARS patients and immunized animals

This study shows that antibodies from SARS-CoV survivors and immunized animals neutralize SARS-CoV-2, suggesting potential for broad-spectrum vaccines against emerging coronaviruses.

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

Bbs5 functions as the docking compartment of Bbsome binding to Klc3 regulated by Bbs5-Ser246 PKC-phosphorylation during mouse spermatogenesis

FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT) interacts with OsIRO2 to regulate iron homeostasis

OsFIT interacts with OsIRO2 to enhance its nuclear accumulation and activate Fe-uptake gene expression in rice.

Genetic diversity and evolution of Hantaan virus in China and its neighbors

This study analyzes HTNV genetic diversity and evolution in China and neighboring regions, identifying phylogroups, recombination events, and geographic clustering patterns.

High-throughput and all-solution phase African Swine Fever Virus (ASFV) detection using CRISPR-Cas12a and fluorescence based point-of-care system

This paper develops a CRISPR-Cas12a-based system for rapid, sensitive, and specific ASFV detection without nucleic acid amplification, achieving a detection limit of 100 fM.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

The paper shows that SAM depletion leads to adaptive chromatin changes that maintain heterochromatin stability and epigenetic persistence in mice.

SPIKEPIPE: A metagenomic pipeline for the accurate quantification of eukaryotic species occurrences and intraspecific abundance change using DNA barcodes or mitogenomes

SPIKEPIPE accurately quantifies eukaryotic species abundances using DNA barcodes or mitogenomes with high accuracy and repeatability across environmental samples.

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

The paper identifies genes involved in DNA damage response and translation that influence susceptibility to TOP2 poisons in gliomas and other cancers.

Phenological matching drives wheat pest range shift under climate change

This study shows that climate change has caused a northward shift in the range of wheat pests, leading to increased crop damage despite pesticide use.

The Life History of Human Foraging: Cross-Cultural and Individual Variation

The paper analyzes hunting skill data from 1,800 individuals to infer age-related productivity patterns and variation in human foraging.

Strategy for Efficient Importing of NAD Analogs

The paper describes a strategy to develop an efficient importing system for NAD analogs to enhance their application in studying NAD-mediated signaling pathways.