H. Chen

Prdm1 Positively Regulates Liver Group 1 ILCs Cancer Immune Surveillance and Preserves Functional Heterogeneity

This study shows Prdm1 regulates liver cNK cells and ILC1s, affecting cancer metastasis and immune communication, with implications for liver cancer immunotherapy.

Biosynthesis of H-GDGTs linked to ocean oxygen deficiency

The paper identifies the gene responsible for biosynthesizing H-GDGTs and shows its association with oxygen-deficient environments.

Extracellular vesicles from retinal pigment epithelial cells expressing R345W-Fibulin-3 induce epithelial-mesenchymal transition in recipient cells.

Exhaustive search for DNA binding sites of Basillus subtilis transcription factor YsiA by KaScape method

This study uses KaScape to identify YsiA DNA binding sites in B. subtilis, finding that half-sites suffice for binding and revealing new minor sequences.

FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS

This study shows that overproducing cMYC in TP53 and RB1-depleted hESC-derived PNECs leads to aggressive SCLC-like tumors with metastatic properties and NEUROD1 expression.

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

This study develops a trivalent RBD nanoparticle vaccine that protects mice against both merbecovirus and sarbecovirus challenges, including SARS-CoV, MERS-CoV, and SARS-CoV-2.

Quantitative monitoring of neuronal regeneration by functional assay and wireless neural recording

This study uses wireless neural recording to monitor neuronal regeneration in mice after traumatic brain injury, finding that FCCP treatment correlates with recovery of evoked local field potentials.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

Decoding genetic architecture of dog complex traits by constructing fine-scale genomic ancestry of admixture

The paper develops a method to reconstruct fine-scale genomic ancestry in admixed dog breeds and identifies genes associated with body size traits.

Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2

This study identifies 14 ATP-competitive ERK2 inhibitors that select for the R-state conformation, revealing structural changes and allosteric communication mechanisms.

Cep290 is cooperatively maintained at basal body by Cep131-Cep162 and Cby-Fam92 modules

This study identifies two modules, Cep131-Cep162 and Cby-Fam92, that cooperatively maintain Cep290 at the basal body and initiate ciliogenesis.

SIDERITE: Unveiling Hidden Siderophore Diversity in the Chemical Space Through Digital Exploration

SIDERITE identifies new iron-binding molecules by analyzing chemical structures and confirming their iron-binding ability through experimental validation.

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

This study shows intermittent fasting increases IL-22 production by intestinal ILC3s, promoting beigeing of white adipose tissue and improving metabolic health.

Genome analyses reveal the secondary metabolites potentially influence the geographical distribution of Fusarium pseudograminearum populations

This study analyzes genomes of Fusarium pseudograminearum strains to show that secondary metabolite synthesis genes influence their geographical distribution and toxin production.

Cooperation between bacteriocytes and endosymbionts drives function and development of symbiotic cells in mussel holobionts

The paper constructs a single-cell expression atlas of gill tissue in deep-sea mussels to study the molecular function and developmental trajectory of bacteriocytes and their interaction with endosymbionts.

Synergistic activity of rhamnolipid combined with linezolid against linezolid-resistant Enterococcus faecium

This study shows that rhamnolipids combined with linezolid synergistically enhance antibacterial activity against linezolid-resistant Enterococcus faecium through multiple assays and mouse models.

Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression

This paper shows that NR0B2 in myeloid cells reduces Treg expansion and tumor growth by modulating the NLRP3 inflammasome, with small molecule agonists improving ICB efficacy in breast cancer.

Fungal-bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

The paper investigates fungal-bacterial interactions in CSD, finding that fungal species alter bacterial abundance through metabolites, contributing to dysbiosis.

ADAR2 inhibits ER-targeted mRNA translation via regulating nucleolar assembly of signal recognition particle

This study shows ADAR2 inhibits ER-targeted mRNA translation by regulating SRP assembly in the nucleolus without requiring RNA binding or A-to-I editing.

De novo Protein Sequence Design Based on Deep Learning and Validation on CalB Hydrolase

The paper designs novel protein sequences using a Graphormer-based model and validates them on CalB hydrolase, achieving 1.7x higher specific activity than the wild type.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

The SUMO-interacting Motif in NS2 promotes adaptation of avian influenza virus to mammals

This study identifies NS2's SUMO-interacting motif as critical for avian influenza virus adaptation to mammals by enhancing vRNP assembly and ANP32A/B interactions.

Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils

This paper describes a FACS method using quantum dots to isolate high-quality conformational antibodies against insoluble antigens like amyloid fibrils.

Stochastic motion and transcriptional dynamicsof pairs of distal DNA loci on a compacted chromosome

The paper measures the motion and transcriptional dynamics of DNA loci pairs in fly embryos, finding compact organization and fast dynamics that affect gene regulation.

The highly conserved stem-loop II motif is dispensable for SARS-CoV-2

This study shows that the stem-loop II motif in SARS-CoV-2 is not essential for viral growth in vitro or in vivo.

MAPS: Pathologist-level cell type annotation from tissue images through machine learning

MAPS provides pathologist-level cell type annotation from spatial proteomics data using machine learning, outperforming existing methods in speed and accuracy.

KaScape: A sequencing-based method for global characterization of protein-DNA binding affinity

KaScape quantitatively characterizes TF-DNA binding affinity across all possible sequences using next-generation sequencing and provides a tool to visualize the affinity landscape.

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

The tRNA Gm18 Methyltransferase TARBP1 Promotes Hepatocellular Carcinoma Progression via Metabolic Reprogramming of Glutamine

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.