J. Yang

Urine proteomic analysis of patients with schizophrenia

This study identifies 35 differential urinary proteins between unmedicated schizophrenia patients and healthy controls, with 15 linked to schizophrenia mechanisms, showing potential as diagnostic markers.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma

This study identifies pyrvinium pamoate as a potential therapy for Merkel cell carcinoma by targeting Wnt signaling and multiple cancer vulnerabilities.

Berberine impairs spermatogenesis in mice by modulating ornithine metabolism via gut microbiota regulation

This study shows berberine reduces sperm count and testosterone in mice by altering gut microbiota, specifically reducing Muribaculaceae, and affecting ornithine metabolism.

A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer

This study identifies CLIC1 as a key molecule linking matrix stiffness and the Warburg effect in pancreatic cancer, promoting tumor growth through ROS/HIF1 signaling.

A mechanical circuit in End4p coordinates force transmission during clathrin-mediated endocytosis

This study identifies a mechanical circuit in End4p that regulates force transmission during clathrin-mediated endocytosis in fission yeast.

Unlocking cellular plasticity: Enhancing human iPSC reprogramming through bromodomain inhibition and extracellular matrix gene expression regulation

This study shows that PFI-3 enhances iPSC reprogramming by promoting mesenchymal-epithelial transition and reducing extracellular matrix gene expression in human fibroblasts.

Alasemenia, the earliest ovule with three wings and without cupule

The paper describes a new Devonian ovule, Alasemenia tria, with three wings and no cupule, suggesting early evolution of wind dispersal mechanisms in seed plants.

Investigation of H9N2 avian influenza immune escape mutant that lacks haemagglutination activity

This paper identifies an H9N2 avian influenza virus mutant with a G149E mutation in HA that loses haemagglutination activity but retains replication fitness, highlighting challenges for vaccine and surveillance efforts.

In vivo Imaging using Surface Enhanced Spatially Offset Raman Spectroscopy (SESORS): Balancing Sampling Frequency to Improve Overall Image Acquisition

This paper introduces SESORRS, a technique combining SERRS and SORS for in vivo tumor imaging, showing improved SNR and faster acquisition of deep-seated tumor data.

Quantitative Learning of Cellular Features From Single-cell Transcriptomics Data Facilitates Effective Drug Repurposing

This study introduces SuperFeat, a framework that uses single-cell transcriptomics data to identify drug targets by modeling adverse cellular states, validated in vitro and in vivo.

Machine Learning Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers

This paper introduces a machine learning framework to identify and target transcriptomic vulnerabilities in colorectal cancer, demonstrating that differentiation therapy selectively eliminates cancer stem cells and reduces recurrence risk.

Environmental factors and cultural drift influence song evolution in New World Sparrows

This study uses deep machine learning to analyze New World Sparrows' songs, finding that environmental and cultural factors significantly influence song evolution, comparable to genetic factors.

Resolving the climatic and ecological drivers of geographical gradients in avian sexual selection

The paper quantifies sexual selection intensity across bird species globally, showing latitudinal gradients influenced by climate and ecological factors.

Wall-following: phylogenetic context of an enhanced behaviour in stygomorphic Sinocyclocheilus (Cypriniformes: Cyprinidae) cavefishes

This study examines wall-following behavior in Sinocyclocheilus cavefish, finding that eyeless species exhibit enhanced behavior compared to sighted ones, with phylogenetic patterns linking behavior intensity to subterranean adaptation.

PQS and pyochelin in Pseudomonas aeruginosa share inner membrane transporters to mediate iron uptake

This study identifies shared inner membrane transporters for PQS-Fe3+ and PCH-Fe3+ in P. aeruginosa and shows their role in iron uptake and virulence.

Mapping protein-exopolysaccharide binding interaction in Staphylococcus epidermidis biofilms by live cell proximity labeling

This study maps PNAG-binding proteins in S. epidermidis biofilms using proximity labeling and proteomics, identifying EbpS and its LysM domain as key interactors.

Regulatory variation controlling architectural pleiotropy in maize

The paper identifies regulatory variation underlying pleiotropy between leaf angle and tassel branch number in maize using context-specific developmental networks and genome-wide association analyses.

LncRNA SNHG16 modulates paclitaxel resistance in breast cancer by regulating Let-7a-5p/DUSP7

This study shows that SNHG16 promotes paclitaxel resistance in breast cancer by suppressing Let-7a-5p and upregulating DUSP7, suggesting the SNHG16-Let-7a-5p-DUSP7 axis as a potential therapeutic target.

Structure of the human outer kinetochore KMN network complex

The paper determines the high-resolution cryo-EM structure of the human KMN network, revealing its subunit organization and phosphorylation-dependent regulation.

CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

BacScan: An Unbiased and Genome-Wide Approach to Identify Bacterial Highly Immunogenic Proteins

BacScan identifies highly conserved immunogenic bacterial proteins across serotypes, showing potential for vaccine development.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

Endothelial SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in mice

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

Habitat correlates of cave-dwelling: A radiation-scale analysis of skin traits and comparative transcriptomics of the Sinocyclocheilus cavefish

This study identifies habitat-related transcriptional differences in skin traits of Sinocyclocheilus cavefish using comparative transcriptomics and RNA-seq.

Multigenerational effects of tire wear particle leachate through trophic transfer from producer to primary consumer

This study shows that TWP leachate ecotoxicity transfers from algae to rotifer through food chains and accumulates across generations, increasing ecological risk.

In Vivo Three-dimensional Brain Imaging with Chemiluminescence Probes in Alzheimers Disease Models

This paper develops chemiluminescence probes for in vivo 3D brain imaging in Alzheimer's disease models, showing high photon emission and binding to amyloid beta.

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

This study shows JMJD6 links pre-mRNA splicing and metabolism in MYC-driven cancers, and its inhibition enhances therapeutic response to splicing inhibitors.

Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism

This study shows that depleting lamins B1 and B2 changes chromatin mobility and gene expression through mesoscale-motion dependent mechanisms.

Effect of Acute Stress on Working Memory in Pilots: Investigating the Modulatory Role of Memory Load

This study examines how acute stress affects working memory in pilots under varying memory loads, finding an interaction where stress may improve accuracy in moderate loads.