Malaria Research and Control

MULTIPLE, REDUNDANT CARBOXYLIC ACID TRANSPORTERS SUPPORT MITOCHONDRIAL METABOLISM IN PLASMODIUM FALCIPARUM

The paper identifies multiple redundant carboxylic acid transporters in Plasmodium falciparum that support mitochondrial metabolism, revealing metabolic flexibility in the parasite.

upsAI: A high-accuracy machine learning classifier for predicting Plasmodium falciparum var gene upstream groups

The paper introduces upsAI, a machine learning classifier that accurately predicts Plasmodium falciparum var gene upstream groups from partial sequences, achieving high accuracy compared to existing tools.

Generation of a transgenic P. cynomolgi parasite expressing P. vivax circumsporozoite protein for testing pre-erythrocytic malaria vaccines in non-human primates

This paper generates a transgenic P. cynomolgi parasite expressing P. vivax CSP to study anti-CSP interventions against relapsing malaria.

Genome-wide association studies on malaria in Sub-Saharan Africa: a scoping review

This paper reviews GWAS on malaria in Sub-Saharan Africa, finding 99 relevant studies mostly from Kenya and Gambia, with a focus on genetic variants linked to malaria susceptibility, resistance, and severity.

Larval surveys reveal breeding site preferences of malaria vector Anopheles spp. in Zanzibar City

The paper surveys larval breeding sites of malaria vectors in Zanzibar City and finds they prefer concrete, semipermanent water bodies with high dissolved oxygen, not yet using polluted sites.

Mechanistic Insights into the Plasmodium Phosphatase UIS2 in eIF2α Dephosphorylation via Integrated Structure-Based Modeling

This study identifies the structural basis of UIS2-mediated eIF2α dephosphorylation in Plasmodium using integrated modeling and shows how Salubrinal inhibits this process.

Natural killer cell function in children with severe malaria differs according to malaria transmission intensity

This study examines NK cell function in children with severe malaria in areas of low and moderate transmission, finding reduced IFN-gamma production but variable degranulation patterns.

Reversible host cell surface remodelling limits immune recognition and maximizes transmission of Plasmodium falciparum gametocytes

This study shows that surface remodelling in Plasmodium falciparum gametocytes helps evade immune detection and facilitates transmission by controlling their sequestration and release into the bloodstream.

Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humans

This study examines humoral and cellular immunity to genetically attenuated malaria parasites in humans and identifies key liver-stage antigens for vaccine development.

The dynamic transcriptome of Plasmodium malariae in the mosquito

This study analyzes the transcriptome of Plasmodium malariae during mosquito transmission, identifying developmentally regulated genes and unique transcription factor patterns.

A Tale of Two Parasites: A Glimpse into the clinical RNA Methylome of Plasmodium falciparum and Plasmodium vivax isolates

The paper analyzes RNA methylation and alternative splicing in Plasmodium falciparum and P. vivax clinical isolates using Nanopore sequencing to reveal transcriptome diversity and regulatory mechanisms.

The influence of Temperature and Relative Humidity on the Development and Survival of Laboratory-Reared Anopheles arabiensis in Ethiopia

This study examines how temperature and humidity affect the development and survival of Anopheles arabiensis mosquitoes in Ethiopia, finding optimal conditions for egg hatchability and adult emergence.

Genetic differentiation in Anopheles stephensi from India and Ethiopia: insights from mitochondrial genome analysis

This study analyzes mitochondrial genomes of Anopheles stephensi from India and Ethiopia to reveal genetic differentiation and multiple lineages, suggesting independent introductions.

Characterizing Plasmodium falciparum genetic diversity and complexity of infections in clinical malaria infections in Western and Coastal Kenya using the poly-alpha microsatellite marker

The paper uses poly-microsatellite markers to analyze genetic diversity and complexity of malaria infections in two Kenyan regions, finding higher complexity in Busia compared to Kilifi.

Globally prevalent Kelch13 mutations increase partial artemisinin resistance and fitness in Bangladeshi Plasmodium falciparum parasites

The paper evaluates the impact of K13 mutations on artemisinin resistance and parasite fitness in Bangladeshi Plasmodium falciparum isolates, finding that R561H confers extreme resistance and fitness advantages.

A CRISPR homing screen finds a chloroquine resistance transporter-like protein of the Plasmodium oocyst essential for mosquito transmission of malaria

This study uses a CRISPR homing screen to identify essential genes for malaria transmission in mosquito stages, finding a chloroquine resistance transporter-like protein critical for oocyst development.

Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins

This study compares gametocyte production and transmission fitness of ART-sensitive and ART-resistant P. falciparum isolates across multiple mosquito species.

Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa

The paper analyzes the evolution and prevalence of dhfr and dhps resistance alleles and haplotypes across Africa using whole genome data from multiple countries.

Genetic mapping of resistance: A QTL and associated polymorphism conferring resistance to alpha-cypermethrin in Anopheles funestus

This study identifies a QTL and associated polymorphisms conferring resistance to alpha-cypermethrin in Anopheles funestus using genetic crosses and BSA mapping.

Plasmodium Repetome: A mysterious space with a wealth of information

The paper analyzes the repeat content in Plasmodium species, finding P. falciparum and P. vivax to be exceptionally rich in tandem repeats, with implications for protein function and parasite biology.

Seasonal transcriptional profiling of malaria parasites using a new single-cell atlas of a Malian Plasmodium falciparum isolate

This study uses single-cell RNA-seq to profile seasonal changes in Plasmodium falciparum parasites, showing older parasites circulate in the dry season and transcriptional changes in exported proteins affecting cytoadhesion.

Mean daily temperatures can predict the thermal limits of malaria transmission better than rate summation

The paper compares thermal suitability models for malaria transmission using constant and fluctuating temperatures, finding that constant temperature models better predict thermal limits than rate summation.

Unlocking new understanding of Plasmodium sporozoite biology with expansion microscopy

This study uses expansion microscopy to investigate sporozoite biology in malaria parasites, revealing new insights into rhoptry function and identifying a key protein involved in invasion.

Comparative study of Anopheles gambiae larval habitats and larval densities in relation to physicochemical parameters in three urban sites in Abidjan district.

This study examines Anopheles gambiae larval habitats and their relationship with environmental factors in three urban areas of Abidjan, finding significant seasonal variations and correlations between physicochemical parameters and larval density.

Malaria parasites undergo a rapid and extensive metamorphosis after invasion of the host erythrocyte

This study shows that Plasmodium falciparum undergoes a rapid metamorphosis after invading erythrocytes, mediated by PV6, which aids parasite survival by altering erythrocyte surface area.

Field Survey of Anopheles Mosquito and Their Culturable Gut Bacteria in the Border Regions of Yunnan Province, China

The paper conducts field surveys of Anopheles mosquitoes and their gut bacteria in Yunnan Province, China, identifying key species and bacteria with potential anti-malaria properties.

Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria

This study identifies two IFN-I-driven hepatocyte antimicrobial programs that control liver-stage malaria by inducing GBPs and lysosomal defense mechanisms.

Circadian rhythms mediate malaria transmission potential

The paper shows that mosquito salivary gland and sporozoite gene expression cycles with the day-night rhythm, affecting malaria transmission.

Temporal patterns of haplotypic and allelic diversity reflect the changing selection landscape of the malaria parasite Plasmodium falciparum

The paper analyzes temporal changes in haplotypic and allelic diversity in Plasmodium falciparum to understand how drug selection pressures shape genetic adaptation.

Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health

The paper develops MAD4HatTeR, an amplicon sequencing panel and analysis pipeline for detecting Plasmodium falciparum diversity, resistance markers, and gene duplications/deletions, showing high sensitivity and reproducibility across settings.