Malaria Research and Control

A redesigned TetR-aptamer system to control gene expression in Plasmodium falciparum

The paper redesigns a TetR-aptamer system to improve stability and efficiency in controlling gene expression in Plasmodium falciparum.

Genomic and transcriptomic evidence for descent from Plasmodium and loss of blood schizogony in Hepatocystis parasites from naturally infected red colobus monkeys

The paper presents genomic and transcriptomic evidence showing Hepatocystis parasites are closely related to Plasmodium but lack blood replication and have lost genes involved in red blood cell invasion.

Malaria Outbreak Detection with Machine Learning Methods

The paper compares machine learning methods for malaria outbreak detection using environmental and epidemiological data from Maharashtra, India, achieving zero false positives and negatives in testing.

Inversion Genotyping in the Anopheles gambiae Complex Using High-Throughput Array and Sequencing Platforms

The paper develops tag SNPs to genotype chromosomal inversions in Anopheles gambiae mosquitoes, showing molecular methods are as accurate as cytogenetics and more scalable.

Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq

This study develops DAFT-seq, an amplification-free RNA-seq protocol for P. falciparum, refining the transcriptome by improving coverage of AT-rich regions and identifying new transcriptional features.

Extensive genetic diversity in Plasmodium vivax from Sudan and its genetic relationships with other geographical isolates

This study analyzes genetic diversity and relationships of Plasmodium vivax isolates from Sudan using microsatellite markers, revealing high diversity and potential recent introductions from Asia.

Effect of irradiation on the survival and susceptibility of female Anopheles arabiensis to natural isolates of Plasmodium falciparum

This study evaluates how irradiation affects the survival and pathogen transmission ability of female Anopheles arabiensis mosquitoes exposed to Plasmodium falciparum.

Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

The paper develops and validates PCR assays to detect plasmepsin 2/3 and pfmdr1 copy number variations in Plasmodium falciparum field isolates, finding increasing plasmepsin 2/3 duplications and loss of pfmdr1 mutations in Cambodia.

Modeling consensus and distance to delivering indoor residual spray (IRS) implementation strategies to control malaria transmission

This paper models the distance to delivering IRS implementation strategies in Zambia, finding that risk prioritization strategies vary in their distance estimates and do not necessarily correlate with remoteness.

An extensive computational approach to inhibit MSP-1 of P.vivax elucidates further horizon in the establishment next generation therapeutics against malaria

The paper uses computational methods to identify potential inhibitors of MSP-1 in P. vivax, suggesting new therapeutic targets for malaria treatment.

A Novel Multiplex qPCR Assay for Detection of Plasmodium falciparum with Histidine-rich Protein 2 and 3 (pfhrp2 and pfhrp3) Deletions in Polyclonal Infections

This paper develops a multiplex qPCR assay to detect Plasmodium falciparum and identify pfhrp2 and pfhrp3 deletions in field samples with high sensitivity and specificity.

The Impact of Antimalarial Resistance on the Genetic Structure of Plasmodium falciparum in the DRC

This study analyzes the genetic structure of Plasmodium falciparum in the DRC, identifying an east-west haplotype divide linked to antimalarial resistance and evidence of gene flow and selection pressures.

Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains

The paper shows that Plasmodium falciparum strains use different invasion strategies based on red blood cell age and accessibility, revealing specialist and generalist behaviors affecting parasitemia.

Epigenetic regulation underlying Plasmodium berghei gene expression during its developmental transition from host to vector

The paper investigates epigenetic regulation in Plasmodium berghei during its developmental transition, identifying HP1 and H3K9ac roles in gene expression and uncovering DNA motifs associated with ookinete-specific genes.

Identity-by-descent relatedness estimates with uncertainty characterise departure from isolation-by-distance between Plasmodium falciparum populations on the Colombian-Pacific coast

The paper estimates IBD-relatedness with uncertainty between Plasmodium falciparum populations and finds connectivity between Buenaventura and Tumaco is higher than expected under isolation-by-distance.

A novel metabarcoded DNA sequencing tool for the detection of Plasmodium species in malaria positive patients

The paper introduces a metabarcoded DNA sequencing method for detecting Plasmodium species in human malaria patients, showing improved diagnostic performance compared to an immunochromatographic assay.

Modelling the epidemiology of residual Plasmodium vivax malaria in a heterogeneous host population: a case study in the Amazon Basin

The paper models residual Plasmodium vivax malaria transmission in the Amazon Basin, finding that 20% of hosts contribute 86% of the malaria burden through high-risk individuals.

Rapid emergence of clonal interference during malaria parasite cultivation

The paper tracks genomic diversity in Plasmodium falciparum during in vitro cultivation, showing increased growth rate and clonal interference over 84 asexual cycles.

Antagonistic roles of NOT1 paralogues in the timing of gene expression in Plasmodium falciparum

This study shows that two NOT1 paralogues in Plasmodium falciparum have opposing roles in regulating mRNA abundance during the intraerythrocytic developmental cycle.

Ensemble Machine Learning Modeling for the Prediction of Artemisinin Resistance in Malaria

This paper develops ensemble machine learning models to predict Artemisinin resistance and parasite clearance rates in Plasmodium falciparum isolates using transformed data and preprocessing techniques.

Falciparum malaria from coastal Tanzania and Zanzibar remains highly connected despite effective control efforts on the archipelago

The paper uses whole-genome sequencing to show that Plasmodium falciparum parasites in Zanzibar and mainland Tanzania share genetic ancestry, indicating ongoing importation despite malaria control efforts.

Anopheles gambiae maternal age and parous state control offspring susceptibility to Plasmodium falciparum

The paper shows that maternal age and parous state in Anopheles gambiae affect offspring susceptibility to Plasmodium falciparum, influencing malaria transmission.

Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential

The paper compares genome structure, sequence, and immunogenic potential of Plasmodium falciparum strains used in vaccine trials and finds significant differences affecting vaccine efficacy.

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and Oceania

This study identifies five genome-wide associations with severe malaria risk in 17,000 individuals from Africa, Asia, and Oceania, including a new variant linked to cerebral malaria.

Surprising variation in the outcome of two malaria genetic crosses using humanized mice: implications for genetic mapping and malaria biology

The paper reports two new genetic crosses of Plasmodium falciparum in humanized mice, showing significant variation in marker segregation and demonstrating improved power for genetic mapping of malaria traits.

Metabolic balancing by miR-276 shapes the mosquito reproductive cycle and Plasmodium falciparum development

This study shows that miR-276 regulates the mosquito reproductive cycle and impacts Plasmodium falciparum development by modulating amino acid metabolism.

Functional genetic validation of key genes conferringinsecticide resistance in the major African malaria vector,Anopheles gambiae

This paper functionally validates three genes associated with insecticide resistance in Anopheles gambiae by overexpressing them in transgenic mosquitoes and showing their role in resistance to different insecticide classes.

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

The paper presents an open dataset of Plasmodium falciparum genome variation from 7,000 worldwide samples, revealing widespread drug resistance and geographic genetic differentiation.

Plasmodium vivax Malaria viewed through the lens of an eradicated European strain

The paper generates a genome from a historical European Plasmodium vivax strain, revealing its evolutionary relationship to American strains and the presence of drug resistance variants predating their use.

First genome-wide association study of non-severe malaria in two birth cohorts in Benin.

This paper conducts the first GWAS on non-severe malaria in infants, identifying genetic variants associated with susceptibility to mild malaria and highlighting candidate genes involved in innate immunity.