Epilepsy research and treatment

Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges

The paper shows that interictal epileptiform discharges (IEDs) are bidirectional traveling waves that follow the same path and direction as ictal discharges, suggesting they originate outside the seizure focus.

A unified physiological framework of transitions between seizures, sustained ictal activity, and depolarization block at the single neuron level

Vascular topology is acutely impacted by experimental febrile status epilepticus

The paper identifies acute vascular topological changes in the cortex and basolateral amygdala following experimental febrile status epilepticus in rats, which may underlie an MRI signal predictive of future epilepsy.

The Interaction Between The Noradrenergic Neurons In The Locus Coeruleus And Beta-1 Adrenergic Receptor (β1-AR) In The Cardiomyocytes Was Implicated In Modulating SUDEP

This study investigates the role of noradrenergic neurons in the locus coeruleus and β1-AR in cardiomyocytes in modulating SUDEP through respiratory and cardiac arrhythmias.

Respiratory Alkalosis Provokes Spike-Wave Discharges in Seizure- Prone Rats

The paper shows that hyperventilation triggers seizures in rats by activating pH-sensitive neurons in the thalamus.

Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eEF2K

This study shows that inhibiting eEF2K reduces seizures and behavioral issues in a Dravet syndrome mouse model by enhancing GABAergic transmission.

Disruption of synaptic transmission in the Bed Nucleus of the Stria Terminalis reduces seizure-induced death in DBA/1 mice and alters brainstem E/I balance

This study disrupts synaptic output in the BNST of DBA/1 mice to reduce seizure-induced death and alter brainstem E/I balance.

Excess interictal activity marks seizure prone cortical areas and mice in a genetic epilepsy model

This study identifies that excess interictal activity marks seizure-prone cortical areas in a genetic epilepsy model, with altered activity intensity predicting seizure burden.

Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs

This paper evaluates the pharmacoresistance of spontaneous seizures in an intra-amygdala kainate model of temporal lobe epilepsy to various antiseizure drugs, finding resistance to sodium channel inhibitors but sensitivity to GABA modulators and valproate.

4-phenylbutyrate restored GABA uptake and reduced seizures in SLC6A1 variants-mediated disorders

This study shows that 4-phenylbutyrate (PBA) improves GABA uptake and reduces seizures in SLC6A1 mutation-related disorders by enhancing wildtype GAT-1 trafficking.

Structural mapping of GABRB3 variants reveals genotype-phenotype correlation

The paper analyzes GABRB3 variants in a cohort of 71 individuals to identify genotype-phenotype correlations, finding associations between variant locations and specific clinical features.

Beamforming seizures from the temporal lobe

This study evaluates MEG beamformer analysis for identifying seizure onset zones in TLE patients, showing high accuracy in localizing mesial and temporolimbic foci.

Transcriptome analysis reveals higher levels of mobile element-associated abnormal gene transcripts in temporal lobe epilepsy patients

The paper identifies higher levels of mobile element-associated abnormal gene transcripts in temporal lobe epilepsy patients, particularly in those with hippocampal sclerosis.

PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model.

This study shows that reducing PGC-1α in PV interneurons decreases seizure-like activity in an acute epilepsy model by limiting interneuron firing intensity.

Topographic divergence of atypical cortical asymmetry and regional atrophy patterns in temporal lobe epilepsy: a worldwide enigma study

This study identifies divergent patterns of atypical cortical asymmetry and regional atrophy in temporal lobe epilepsy using MRI data from a large multi-site cohort.

Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model

This study shows that enhancing KCC2 function with CLP290 rescues PB-resistant neonatal seizures and reduces epileptogenesis in a mouse model.

Refining epileptogenic high-frequency oscillations using deep learning: a reverse engineering approach

This paper develops a deep learning algorithm to detect and classify epileptogenic high-frequency oscillations (eHFOs) from intracranial EEG data with high accuracy.

Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures and hypoactivity

This study shows that loss of eaat2a in zebrafish causes seizures and reduced neuronal activity due to glutamate imbalance.

Distinct fastigial output channels and their impact on temporal lobe seizures

The paper identifies distinct fastigial output channels in mice and shows that stimulating neurons targeting the central lateral thalamus, but not other regions, effectively inhibits hippocampal seizures.

Genetic expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy

This study shows that increasing 4E-BP1 activity in juvenile mice with FMCD reduces neuronal dysfunction and seizures by correcting electrophysiological and structural abnormalities.

Continuous Seizure Emergency Evoked in Mice with Pharmacological, Electrographic, and Pathological Features Distinct from Status Epilepticus

This paper introduces a novel mouse model of sustained seizure emergency with distinct pharmacological, electrographic, and pathological features compared to status epilepticus.

Txn1 mutation causes epilepsy associated with vacuolar degeneration in the midbrain

This study identifies a Txn1 mutation causing epilepsy and midbrain vacuolar degeneration in rats, with age-dependent neuronal and oligodendrocyte cell death and repair.

The cerebellum contributes to tonic-clonic seizures by altering neuronal activity in the ventral posteromedial nucleus (VPM) of the thalamus

This study identifies the ventral posteromedial nucleus of the thalamus as a source of tonic-clonic seizures, showing cerebellar input drives seizure initiation.

Distinct signatures of loss of consciousness during Focal Impaired Awareness versus Focal to Bilateral Tonic-Clonic seizures

The paper compares loss of consciousness mechanisms in focal impaired awareness and focal to bilateral tonic-clonic seizures using intracranial EEG data from patients.

Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures

This study shows that deleting calcineurin in astrocytes leads to proteome changes resembling Alzheimer's and epilepsy, and increases seizure risk in mice.

Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy.

The paper analyzes transcriptomic data from pilocarpine-induced temporal lobe epilepsy to identify predictive biomarkers and cellular mechanisms, revealing aberrant interactions between cell types and potential drug targets.

Ultra-rare constrained missense variants in the epilepsies: Shared and specific enrichment patterns in neuronal gene-sets

The paper analyzes ultra-rare variants in epilepsy patients to identify gene-set enrichment patterns and differential impacts in neuronal gene categories.

Pathological and metabolic underpinnings of energetic inefficiency in temporal lobe epilepsy

This study uses network control theory to analyze energy dynamics in temporal lobe epilepsy, finding increased control energy requirements and metabolic asymmetry in affected brain regions.

Somatostatin-positive Interneurons Contribute to Seizures in SCN8A Epileptic Encephalopathy

This study shows that somatostatin-positive interneurons with SCN8A mutations contribute to seizures by causing hyperexcitability and depolarization block.

Synaptic and intrinsic mechanisms impair reticular thalamus and thalamocortical neuron function in a Dravet syndrome mouse model

This paper investigates how NaV1.1 haploinsufficiency affects thalamocortical circuit function in a Dravet syndrome mouse model, revealing input-specific synaptic and intrinsic changes in thalamic neurons.