Epilepsy research and treatment

Lapatinib protects against epileptic seizures via halting glutathione peroxidase 4-dependent ferroptosis

This study shows lapatinib protects against epileptic seizures by inhibiting GPX4-dependent ferroptosis through reducing lipid peroxidation.

Interictal epileptiform discharges in focal epilepsy are preceded by a gradual increase in low-frequency oscillations

The paper examines MEG data from focal epilepsy patients and finds a gradual increase in low-frequency oscillations before interictal epileptiform discharges.

Seizure-associated spreading depression is a major feature of ictal events in two animal models of chronic epilepsy

The paper investigates the relationship between spreading depression and spontaneous seizures in two animal models of chronic epilepsy, finding that SD is associated with a third of seizures and contributes to seizure clustering.

Spectral harmonicity distinguishes two types of ictal phase-amplitude cross frequency couplings in patients candidate to epilepsy surgery

The paper analyzes spectral harmonicity in ictal activity to distinguish between harmonic and non-harmonic phase-amplitude couplings in epilepsy patients, showing its relevance for identifying seizure onset zones.

Local propagation dynamics of MEG interictal spikes: source reconstruction with traveling-wave priors

The paper develops a method to localize epileptic seizure origins using MEG data by modeling spike propagation as traveling waves.

Network-based atrophy modelling in the common epilepsies: a worldwide ENIGMA study

This study identifies network associations with atrophy patterns in epilepsy using neuroimaging and connectome analysis across 1,021 patients and 1,564 controls.

Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy

The paper analyzes seizure network dynamics in focal epilepsy patients, finding that seizure pathways change on circadian and slower timescales, independent of medication.

Adult-born granule cells support pathological microcircuits in the chronically epileptic dentate gyrus

This study investigates how adult-born granule cells contribute to epileptic network activity in the dentate gyrus using in vivo calcium imaging and neural topic modeling.

Dynamic network properties of the interictal brain determine whether seizures appear focal or generalised

The paper introduces three measures to predict seizure onset patterns using interictal brain network properties from scalp EEG data.

Phenotype-based screening of synthetic cannabinoids in a Dravet Syndrome zebrafish model

The paper screens synthetic cannabinoids in a zebrafish model of Dravet Syndrome to identify anti-seizure compounds.

An unbiased drug screen for seizure suppressors in Dup15q syndrome reveals 5HT1A and dopamine pathway activation as potential therapies

This study identifies 5HT1A and dopamine pathway activation as potential therapies for Dup15q syndrome using a Drosophila model and a compound screen.

Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission during epileptogenesis in the mouse CA3 circuit in vivo

The paper measures GABAergic synaptic transmission polarity during epileptogenesis in mouse CA3 hippocampus, finding a temporary reversal from inhibitory to excitatory during post-ictal periods.

Implantation technique, safety and complications of robot-assisted stereoelectroencephalography exploration of the limbic thalamus in human focal epilepsy

This study evaluates the safety and accuracy of robot-assisted stereotactic electrode placement in limbic thalamic nuclei for research in patients with temporal lobe epilepsy.

Polygenic risk scores of several subtypes of epilepsies in a founder population

The paper calculates polygenic risk scores for epilepsy subtypes in a French-Canadian cohort and finds they provide reliable genetic contribution estimates, though clinical use requires further study.

Changes in interictal pretreatment and posttreatment EEG in childhood absence epilepsy

This study shows that CAE patients have higher theta and beta EEG wavelet powers than controls, which decrease after treatment, suggesting potential EEG biomarkers for diagnosis and monitoring.

Deficiency of cyclin-dependent kinase-like 5 causes spontaneous epileptic seizures in neonatal mice

This study identifies spontaneous seizures in CDKL5-deficient mice, showing reduced phosphorylation of K+/Cl- co-transporter 2 and highlighting the translational value of CDD mouse models.

The paradoxical effects of K+ channel gain-of-function are mediated by GABAergic neuron hypoexcitability and hyperconnectivity.

The paper investigates how a gain-of-function K+ channel variant causes seizures by reducing inhibitory neuron excitability and increasing network hyperconnectivity.

NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype in a novel zebrafish model for Dravet Syndrome

This study develops a zebrafish model for Dravet Syndrome and tests compounds that selectively target Nav1.1 or Nav1.6 channels, showing both reduce seizure-like behavior.

Thalamic activity patterns unfolding over multiple time scales predict seizure onset in absence epilepsy

The paper identifies pre-seizure thalamic activity patterns in absence epilepsy that vary across seizures and may improve seizure prediction.

TLR4 signaling in neurons enhances calcium-permeable AMPAR currents and drives post-traumatic epileptogenesis

This study shows that TLR4 signaling in neurons increases calcium-permeable AMPAR currents and promotes post-traumatic epileptogenesis, with early blockade reducing seizure susceptibility.

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

This study uses CRISPRa to increase Kv1.1 expression in mouse hippocampal neurons, reducing seizures and cognitive deficits in a temporal lobe epilepsy model.

Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons

This study uses patient-derived iPSC neurons to show variant-specific changes in sodium currents in SCN8A-EIEE13, identifying altered persistent and resurgent INa and potential therapeutic responses.

Early EEG and behavioral alterations in Dravet mice

This study examines EEG and behavioral changes in Dravet syndrome mice across disease stages, finding reduced EEG power and early behavioral deficits.

Low-dose Perampanel rescues cortical gamma dysregulation associated with parvalbumin interneuron GluA2 upregulation in epileptic Syngap1+/- mice

The paper identifies GluA2 upregulation in parvalbumin interneurons as a cause of gamma dysregulation in Syngap1+/- mice and shows that Perampanel rescues this dysfunction.

LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating JAK/STAT signaling pathway

This study shows that UCA1 inhibits astrocyte activation and improves cognitive function in TLE rats by modulating the JAK/STAT signaling pathway.

A Systems Approach Identifies Enhancer of Zeste Homolog 2 (EZH2) as a Protective Factor in Epilepsy

This paper identifies EZH2 as a protective factor in epilepsy using a systems approach to analyze transcriptomic data from rodent and human samples.

TrkB agonists prevent post-ischemic BDNF-TrkB mediated emergence of refractory neonatal seizures in CD-1 pups.

This study shows that TrkB agonists reduce PB-refractory seizures in neonatal mice by modulating KCC2 stability and TrkB pathway activation post-ischemia.

Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform specific start-loss mutations of essential genes can cause genetic diseases

The paper identifies a recurrent start codon mutation in UGP2 causing a severe epileptic encephalopathy, showing that isoform-specific expression loss of an essential gene can lead to disease.

Comparisons of dual isogenic human iPSC pairs identify functional alterations directly caused by an epilepsy associated SCN1A mutation

The paper compares dual isogenic human iPSC pairs to identify functional alterations caused by an epilepsy-associated SCN1A mutation and its interaction with genetic background.

Interneuron dysfunction in a new knock-in mouse model of SCN1A GEFS+

This study introduces a mouse model with a SCN1A mutation linked to GEFS+ and shows that heterozygous mutants develop seizures due to impaired inhibitory interneuron function.