Epilepsy research and treatment

Absence-like epileptic spike-wave discharges in adult Lister Hooded rats and their pharmacological modulation

The paper reports the presence of spike-wave discharges (SWDs) in Lister Hooded rats and their pharmacological modulation using GABA-B agonists and anti-seizure drugs.

BELIEFS AND ATTITUDES TOWARDS CHILD EPILEPSY: A STRUCTURAL EQUATION MODEL

This study identifies factors influencing beliefs and attitudes towards childhood epilepsy using a structural equation model in a Brazilian cultural context.

Post-ictal generalized EEG suppression and seizure-induced mortality are reduced by enhancing dorsal raphe serotonergic neurotransmission

Neuronal firing and waveform alterations through ictal recruitment in humans

The paper develops a novel spike sorting method to analyze neuronal activity during human seizures, finding that recruited neurons show altered action potential waveforms compared to non-recruited tissue.

Central deficiency of norepinephrine synthesis and norepinephrinergic neurotransmission contributes to seizure-induced respiratory arrest

The paper investigates how norepinephrine synthesis and neurotransmission deficits contribute to seizure-induced respiratory arrest and identifies NE-1R as a potential therapeutic target for SUDEP prevention.

Automated Detection of Ripple Oscillations in Long-Term Scalp EEG from Patients with Infantile Spasms

This study develops an automated method to detect high-frequency oscillations (HFOs) in long-term scalp EEG from infantile spasms patients and healthy controls, showing higher HFO rates in patients and a significant reduction after ACTH treatment.

Ectopic HCN4 expression drives mTOR-dependent epilepsy

The paper identifies ectopic HCN4 expression in FCM neurons as a cAMP-dependent seizure mechanism in TSC and FCDII, suggesting HCN4 as a gene therapy target for epilepsy.

GABAergic signaling promotes early-life seizures in epileptic SYNGAP1+/- mice

This study investigates early-life seizures in SYNGAP1 heterozygous mice and finds that GABAergic signaling promotes seizure generation, with subclinical seizures refractory to some treatments but responsive to others.

Circuit mechanisms underlying chronic epilepsy in a mouse model of focal cortical malformation

The paper identifies synaptic reorganization in a mouse model of focal cortical malformation and shows that optogenetic stimulation of somatostatin interneurons can stop seizures.

Localized Chemogenetic Silencing of Inhibitory Neurons: A novel Mouse Model of Focal Cortical Seizures

This paper introduces a novel mouse model of focal cortical seizures using chemogenetic inhibition of GABAergic neurons, showing reliable induction of seizures with characteristics similar to human epilepsy.

Scalp EEG interictal high frequency oscillations as an objective EEG biomarker of infantile spasms

This study shows that scalp EEG high frequency oscillations (HFOs) and their coupling with slow-wave activity correlate with active infantile spasms and can predict them better than hypsarrhythmia.

LGI1 downregulation increases neuronal circuit excitability

This study shows that reducing LGI1 levels increases neuronal excitability and synaptic plasticity, potentially contributing to epilepsy and limbic encephalitis.

Epilepsy and neurobehavioral abnormalities in mice with a KCNB1 pathogenic variant that alters conducting and non-conducting functions of KV2.1

This paper identifies a KCNB1 pathogenic variant in mice that causes epilepsy and neurobehavioral abnormalities, mimicking human DEE features.

Maximally selective single cell target for circuit control in epilepsy

The paper identifies superhub cells in neural networks that, when targeted, more effectively stabilize epileptic networks compared to traditional hub cells.

High concordance between hippocampal transcriptome of the intraamygdala kainic acid model and human temporal lobe epilepsy

The paper compares gene expression in a mouse model of status epilepticus to human temporal lobe epilepsy tissue, finding high concordance in gene dysregulation and shared molecular features.

Impacted Spike Frequency Adaptation Associated with Reduction of KCNQ2/3 Promotes Seizure Activity in Temporal Lobe Epilepsy

The paper identifies reduced KCNQ2/3 expression and impaired spike frequency adaptation in TLE patients and mouse models, showing their role in promoting seizure activity.

Anterior Nucleus of Thalamus Gates Progression of Mesial Temporal Seizures by Modulating Thalamocortical Synchrony

This study examines thalamocortical synchronization changes in mesial temporal lobe seizures, finding increased synchronization at onset and decreased connectivity at termination, with higher seizure burden correlating with greater synchronization.

In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia

This study investigates the role of postictal hypoperfusion/hypoxia in memory impairments after seizures, finding that synaptic plasticity is specifically affected while other network functions remain intact.

Antisense oligonucleotide therapy for SCN2A gain-of-function epilepsy

This study shows that reducing SCN2A function with an antisense oligonucleotide improves survival and behavior in a mouse model of early seizure onset DEE.

Optogenetic activation of CA1 pyramidal neurons in vivo induces hypersynchronous and low voltage fast seizures

This study shows that optogenetic activation of CA1 pyramidal neurons in mice induces seizures with two distinct patterns, suggesting involvement of TLE-related networks.

An important role of the interplay between Bdnf transcription and histone acetylation in epileptogenesis

The paper investigates the relationship between Bdnf transcription and histone acetylation in epilepsy, finding that Bdnf repositioning correlates with epileptic traits and is influenced by transcriptional activity and histone deacetylase inhibition.

Amplitude of high frequency oscillations as a biomarker of the seizure onset zone

This study compares HFO amplitude and rate as biomarkers for seizure onset zone localization using iEEG data from 11 patients, finding amplitude provides better classification accuracy and consistency.

Global prevalence of potentially pathogenic short-tandem repeats in an epilepsy cohort

The paper identifies a potential pathogenic STR expansion in an epilepsy cohort using whole genome sequencing and three software tools, highlighting discrepancies in variant calling.

Maladaptive myelination promotes epileptogenesis in absence epilepsy

This study shows that maladaptive myelination driven by absence seizures contributes to epileptogenesis in two mouse models of absence epilepsy.

Impaired state-dependent potentiation of GABAergic synaptic currents triggers seizures in an idiopathic generalized epilepsy model

The paper identifies impaired state-dependent potentiation of GABAergic currents in a mouse model of IGE as a mechanism triggering seizures during sleep-like states.

Carbamazepine and GABA have distinct effects on seizure onset dynamics in mouse brain slices

This study examines how GABA and carbamazepine affect seizure onset dynamics in mouse brain slices using bifurcation analysis.

Proteomic and Transcriptomic Analyses of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Cases

The paper compares proteomic and transcriptomic profiles of hippocampus and cortex in SUDEP and high-risk SUDEP cases, finding no proteomic differences but 55 differentially expressed genes in hippocampus.

A taxonomy of seizure dynamotypes

This paper introduces a taxonomy of seizure dynamotypes based on bifurcation theory and applies it to EEG data, identifying 16 dynamotypes and their variations across patients.

Sodium valproate protects against neuronal ferroptosis in epilepsy via suppressing lysyl oxidase

This study shows sodium valproate reduces epileptic seizures by inhibiting Lox-mediated ferroptosis in mouse models and cell cultures.

Seizure onset location shapes dynamics of initiation

The paper examines how seizure onset location influences electrographic patterns and identifies that specific oscillatory dynamics and interactions are more indicative of seizure origin than traditional biomarkers.