Epilepsy research and treatment

Interruption of rat absence seizures by auditory stimulation

This study investigates how auditory stimuli can interrupt absence seizures in rats, finding that stimulus timing, conditioning, and signal power influence seizure termination.

Exploring the likelihood of the membrane pollution hypothesis with a physiologically plausible biophysical model.

The paper explores the plausibility of the membrane pollution hypothesis by simulating the effects of increased membrane micro-viscosity on pacemaker activity.

Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome

The paper shows that increased HCN1 activity in excitatory neurons causes excessive network bursting in Dravet syndrome, suggesting HCN1 as a therapeutic target.

Suppressing cortical glutamatergic neurons produces paradoxical interictal discharges and seizures

The paper shows that suppressing cortical glutamatergic neurons can paradoxically cause seizures and interictal discharges in vivo.

Dysfunctional LHX6 pallido-subthalamic projections mediate epileptic events in a mouse model of Leigh Syndrome

This study identifies dysfunctional pallido-subthalamic projections as a mediator of epilepsy in a mouse model of Leigh Syndrome and suggests STN inhibition as a potential therapeutic target.

Modeling AP2M1 Developmental and Epileptic Encephalopathy in Drosophila

This study models AP2M1-DEE in Drosophila, finding heat-sensitive paralysis, altered neuron morphology, and seizure resistance, suggesting developmental defects over synaptic dysfunction.

Beyond seizure control: identifying deficits in cognitive networks in absence seizure.

The paper investigates cognitive deficits in absence epilepsy by examining thalamic-prefrontal circuit dysfunction in a mouse model, finding impaired reversal learning and identifying potential therapeutic targets.

Protein Biomarker in Focal Cortical Dysplasia: Molecular Clues to Pathogenesis

This study identifies subtype-specific protein biomarker alterations in FCD, highlighting mTOR pathway dysregulation and potential therapeutic targets.

Electrophysiological signatures of a developmental delay in a stem cell model of KCNQ2 developmental and epileptic encephalopathy

This study investigates the developmental impact of KCNQ2 loss-of-function variants in patient iPSC-derived neurons, showing reduced M-currents and disrupted oscillatory activity linked to developmental delay and seizures.

Molecular Deconstruction of the Medullary Raphe Magnus in the rat: Transcriptional Responses to Repeated Seizures

The paper uses snRNA-seq to analyze transcriptional changes in the rat brainstem's Raphe Magnus region after repeated seizures, identifying altered neuronal function without changes in other cell types.

Synaptic Ultrastructural Alterations in Human Focal Cortical Dysplasia: Insights from Volume Electron Microscopy

Volume EM of one focal cortical dysplasia type I patient shows fewer somatic inhibitory and dendritic excitatory synapses, oversized vesicle-rich excitatory synapses, and thicker myelin.

Personalized whole-brain models of seizure propagation

This paper develops personalized whole-brain models of seizure propagation using multimodal clinical data to simulate and evaluate individualized therapeutic strategies.

Evaluating the Efficacy of Propofol Against Isoniazid-Induced Seizures: A Comparative Study with Diazepam and Pyridoxine in Swiss Albino Mice

This study evaluates propofol's efficacy against isoniazid-induced seizures in mice, finding it ineffective compared to diazepam, which significantly reduced seizures and mortality.

Lateral septal inhibition of nucleus basalis through direct and indirect pathways in focal limbic seizures

This study investigates the mechanisms of reduced cortical cholinergic activity during focal seizures using an awake mouse model and electrophysiology, calcium imaging, and neurotransmitter sensing.

Transcriptomic profiles from stereo-EEGs reveal the local cell microenvironment in human epilepsy

The paper uses transcriptomic data from SEEG electrodes to characterize the molecular microenvironment in human epilepsy, showing gene expression reflects local brain activity and cell types.

Interictal activity fluctuations follow rather than precede seizures on multiple time scales in a mouse model of focal cortical dysplasia

Behavior decoding delineates seizure microfeatures and associated sudden death risks in mice

AI-aided behavior decoding identifies seizure microfeatures and SUDEP risks in mice using machine learning tools.

Retuning ventral hippocampal output improves social memory and reduces anxiety-related behavior in temporal lobe epilepsy

This study shows that retuning ventral hippocampal output in TLE mice improves social memory and reduces anxiety without suppressing seizures.

Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons

This study compares neuronal activity and gene expression in CDD patient-derived neurons from two differentiation methods, finding early hyperexcitability in organoid-derived neurons but not induced neurons.

Computational Modelling of Resistance to Hormone-Mediated Remission in Childhood Absence Epilepsy

The paper develops a thalamocortical model to study how neuronal composition and connectivity affect allopregnanolone's effectiveness in resolving seizures in childhood absence epilepsy.

Modeling Cortical Versus Hippocampal Network Dysfunction in a Human Brain Assembloid Model of Epilepsy and Intellectual Disability

This study uses human brain assembloids to model how a genetic epilepsy syndrome affects cortical and hippocampal networks differently, revealing distinct dysfunction patterns.

Region-specific modulation and predictive potential of the oscillatory dynamics in an ex vivo model of ictogenesis in the CA1, CA3 and dentate gyrus

The paper investigates oscillatory dynamics in hippocampal subregions during seizure-like activity and finds that CA1 oscillations predict seizures better, while CA3 and DG show stronger drug modulation.

Functional rather than anatomic connectivity predicts seizure propagation in a multi-node model of focal neocortical epilepsy

This study shows that functional connectivity, not anatomical connections, determines seizure spread in a rodent epilepsy model and highlights how stimulation parameters affect neural recruitment.

Replication of seizure-suppressing effects of alpha-linolenic acid on the Drosophila melanogaster paraShudderer mutant

This study replicates the seizure-suppressing effects of alpha-linolenic acid on the Drosophila paraShudderer mutant, confirming the phenotype's robustness and the treatment's effectiveness across lab environments.

Absence seizures and sleep-wake abnormalities in a rat model of GRIN2B neurodevelopmental disorder

This study characterizes a Grin2b heterozygous knockout rat model, revealing seizure and sleep-wake abnormalities, and tests the efficacy of two antiseizure drugs.

T-401 binding to monoacylglycerol lipase (MAGL) in the brains of patients and mice with temporal lobe epilepsy

The paper evaluates MAGL levels in epileptic brains using [3H]T-401 binding, finding reduced MAGL in multiple brain regions in both human patients and mice.

Exploring Cerebellar Hippocampal Dynamics in Temporal Lobe Epilepsy: A Multivariable Synthetic Modeling Study of Purkinje Cell Degeneration and Stimulation Timing

This study uses synthetic modeling to show that cerebellar stimulation timing, not Purkinje cell integrity, significantly impacts seizure outcomes in temporal lobe epilepsy.

Predicting Drug Response with Multi-Task Gradient-Boosted Trees in Epilepsy

This paper predicts drug response in epilepsy using multi-task gradient-boosted trees, identifying key genomic and clinical features that influence treatment outcomes.

Females with epilepsy show abnormal changes to perimenstrual sensory induced long-term potentiation

This study shows that females with epilepsy exhibit enhanced visual long-term potentiation (LTP) in the perimenstrual phase compared to mid-follicular and mid-luteal phases, suggesting increased glutamatergic excitation.

Associations between epilepsy-related polygenic risk and brain morphology in childhood

The paper examines associations between epilepsy-related polygenic risk scores and brain morphology in children, finding PRS-related cortical thinning linked to structural patterns in TLE-HS patients.