Epilepsy research and treatment

Ion Dynamics Underlying the Seizure Delay Effect of Low-Frequency Electrical Stimulation

This study uses computational modeling and in vitro experiments to investigate how low-frequency electrical stimulation delays seizures by modulating ion dynamics and neuronal excitability in rat hippocampal slices.

A zebrafish seizure model of cblX syndrome reveals a dose-dependent refractory response to mTor inhibition.

This study uses a zebrafish model of cblX syndrome to show that mTor inhibition at moderate doses reduces seizure severity, but higher doses cause a refractory response in hcfc1a mutants.

DIME: Data-driven Importance MEtric Guides Localization of the Seizure Onset Zone from Intracranial EEG Data

DIME improves SOZ localization using iEEG data, achieving high recall and accuracy in predicting surgical outcomes.

Senescent cell clearance ameliorates temporal lobe epilepsy and associated spatial memory deficits in mice

This study shows that clearing senescent cells reduces seizures and improves memory in a mouse model of temporal lobe epilepsy and finds similar SC accumulation in human TLE patients.

A DC-sensitive video/electrophysiology monitoring unit for long-term continuous study of seizures and seizure-associated spreading depolarization in a rat model

This paper introduces a low-cost, high-fidelity epilepsy monitoring unit for long-term continuous recording of seizures and spreading depolarization in freely moving rats.

Modelling dysfunction-specific interventions for seizure termination in epilepsy

This paper uses a neural mass model to show how different dysfunctions cause seizures and how targeted interventions can terminate them effectively.

Loss of presenilin 2 function age-dependently increases susceptibility to kainate-induced acute seizures and blunts hippocampal kainate-type glutamate receptor expression

This study shows that loss of presenilin 2 function increases seizure susceptibility in young mice but not in aged mice, and reduces GluK5 expression in aged PSEN2 knockout mice.

SEIZURE OCCURRENCE IN FCD TYPE II IS PREDICTED BY LESION POSITION AND LINKED TO CYTOARCHITECTURAL ALTERATIONS

This study investigates seizure occurrence in FCD type II by analyzing lesion position and cytoarchitectural changes in a mouse model.

Early death and neuronal abnormalities in depdc5 loss-of-function mosaic zebrafish models

This study generates mosaic depdc5 loss-of-function zebrafish models to study DEPDC5-related epilepsy and early death, finding increased seizure-like behavior and neuronal hyperexcitability.

Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

This paper identifies novel epilepsy modifier genes in mice through meta-analysis of GWAS data and functional network analysis, highlighting genes involved in neurodevelopmental processes not targeted by current therapies.

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab

The paper develops a protocol to characterize epileptogenic tissue using multimodal data from surgical samples, aiming to improve diagnosis and treatment of drug-resistant epilepsy.

Human Mediodorsal Thalamus in Seizure Propagation

This study analyzes thalamic seizure propagation patterns in patients with focal seizures, finding that the mediodorsal thalamus is frequently involved but not typically the first site engaged during seizure onset.

White Matter Signals Reflect Information Transmission Between Brain Regions During Seizures

This study shows white matter signals during seizures reflect communication between brain regions and differentiate epilepsy pathophysiologies, challenging past assumptions about their limited value.

Elevated Thalamic Blood Flow in Self-Limited Epilepsy with Centrotemporal Spikes

The paper finds elevated thalamic blood flow in children with SeLECTS compared to controls, with variations based on spike distribution and antiseizure medications.

NDNF+ interneurons have a privileged role in regulating cortical excitability

This study shows NDNF+ interneurons regulate cortical excitability, with depolarization suppressing seizures and hyperpolarization exacerbating them, mediated by GABAB receptors.

Visual detection of seizures in mice using supervised machine learning

This study uses supervised machine learning to automatically quantify seizure severity from video data in mice, enabling high-throughput and standardized seizure scoring.

Toward Unified Biomarkers for Focal Epilepsy

The paper develops a probabilistic model to identify epileptogenic networks using interictal SEEG data, achieving high classification accuracy with a reduced feature space.

EEG Functional Connectivity as a Marker of Evolution from Infantile Epileptic Spasms Syndrome to Lennox-Gastaut Syndrome

The paper uses EEG functional connectivity to track progression from infantile epileptic spasms syndrome to Lennox-Gastaut Syndrome and identifies patterns associated with treatment response and disease markers.

Sensory Circuit Dynamics in a Mouse Model of Epileptic Encephalopathy

This study investigates cortical circuit dynamics in Ank3-1b-/- mice, showing disrupted excitatory-inhibitory balance and altered sensory processing, while some sensory functions remain preserved.

Personalized Biomarkers of Multiscale Functional Alterations in Temporal Lobe Epilepsy

This study identifies patient-specific functional biomarkers in temporal lobe epilepsy using multimodal MRI data to predict clinical outcomes and guide precision therapeutics.

Daily intermittent fasting is an effective multiscale treatment in preclinical models of absence epilepsy

This study shows that daily intermittent fasting reduces seizure frequency and improves sociability in mouse models of absence epilepsy without adverse effects.

Hyperthermic Seizure Susceptibility and Focal Decreases in Parvalbumin-Expressing Cortical Interneurons in a Mouse Model of PCDH19-Clustering Epilepsy

This study investigates a mouse model of PCDH19-clustering epilepsy, finding hyperthermia-induced seizures and reduced parvalbumin-expressing interneurons in specific brain regions.

Autonomic reflex plasticity associates with time-dependent SUDEP susceptibility in a murine model with hyperreactive stress circuits

This study shows that hyperreactive stress circuits in mice increase time-dependent SUDEP susceptibility through exaggerated autonomic reflexes following seizure induction.

Robust dual dynamics of ictogenesis in temporal lobe seizures in vivo

The paper examines seizure initiation dynamics in temporal lobe epilepsy using in vivo two-photon calcium imaging, finding two distinct yet stable initiation pathways involving excitatory and inhibitory neurons.

A novel mouse model for developmental and epileptic encephalopathy by Purkinje cell-specific deletion of Scn1b

This study develops a novel mouse model with Purkinje cell-specific Scn1b deletion, revealing cerebellar dysfunction and associated neurological impairments without early mortality.

Minimally invasive activation of spared interneurons alleviates local CA1 hypersynchrony and behavioral deficits in a model of temporal lobe epilepsy

This study investigates the role of Dlx-expressing interneurons in TLE, finding they are largely spared but show reduced activity, and that enhancing their activity can improve cognitive function.

Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

The paper develops ImPheNet, a deep learning tool to classify phenotypes and assess drug toxicity in Dravet Syndrome brain organoids using live imaging data.

A splice-switching antisense oligonucleotide approach for pediatric genetic epilepsies

This study identifies splice-switching antisense oligonucleotides that correct splicing defects in SCN8A, reducing seizures and improving survival in a mouse model of genetic epilepsy.

Microstructural Spine Alterations Increase Neuronal Excitability in Focal Cortical Dysplasia

This study shows that reduced spine density and weakened neck compartmentalization in FCD increase neuronal excitability, contributing to epileptogenesis beyond inhibitory deficits.

HIF1α-dependent induction of the T-Type calcium channel CaV3.2 mediates hypoxia-induced neuronal hyperexcitability

The paper identifies HIF1α as a regulator of CaV3.2 expression, linking hypoxia to neuronal hyperexcitability and epileptogenesis.