Developmental Biology and Gene Regulation

Embryo-eggshell interaction counteracts chiral bias in early Drosophila morphogenesis

The paper shows that Scab integrin-mediated attachment to the vitelline envelope suppresses chirality-induced twisting in Drosophila germ band extension.

A conserved C. elegans zinc finger-homeodomain protein, ZFH-2, continuously required for structural integrity and function of alimentary tract and gonad

Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis

This study identifies sumf2 as a key regulator of convergence and extension morphogenesis timing in zebrafish by modulating sulfatase activity and heparan sulfate sulfation.

Notch-mediated thyroid hormone regulation of skin development in the zebrafish caudal fin

The paper investigates how thyroid hormone regulates skin development in zebrafish caudal fin by acting through the Notch pathway to control cell proliferation and hypertrophy during maturation.

Functional definition of the Drosophila airway progenitor field through overlapping compensatory regulators

The paper defines the Drosophila airway progenitor field through three cooperative regulatory programs and their roles in morphogenesis.

Permissive and instructive Hox codes govern limb positioning

This study identifies Hox4/5 and Hox6/7 genes' roles in forelimb positioning through loss- and gain-of-function experiments in chick embryos, showing Hox4/5 provide permissive cues and Hox6/7 determine limb position.

Mitotically Driven Cytoskeletal Reorganization Governs Zebrafish Left-Right Organizer Detachment from EVL and Lumen Morphogenesis

The paper shows that early cytokinesis drives cytoskeletal reorganization in zebrafish Kupffer's vesicle, enabling lumen formation and detachment from the enveloping layer.

Reconstituting Mouse Embryogenesis Ex Utero from Gastrulation to Fetal Development Reveals Maternally Independent Metabolic Programs

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Oscillatory Hedgehog signaling and temporal coordination of atonal dynamics at the eye differentiation front in Drosophila

This study investigates how Hedgehog signaling coordinates oscillatory atonal gene expression in Drosophila eye development.

Med12 and Med13 prevent tumorigenic dedifferentiation of intermediate neural progenitors and premature loss of neural stem cells

This study shows Med12 and Med13 prevent dedifferentiation of intermediate neural progenitors and loss of neural stem cells in Drosophila by regulating gene expression through interactions with different mediator complex subsets.

BMP antagonism is required for mandible outgrowth in zebrafish

This study identifies the role of BMP antagonists in sustaining mandibular growth in zebrafish by regulating chondrocyte differentiation and cartilage organization.

Comparative human embryo-mapping reveals neural bias of neuromesodermal progenitors in stem cell axial elongation models

The paper maps scRNA-seq from stem cell-based axial organoids to a human embryo, revealing three origins of axial development and the neural bias of neuromesodermal progenitors.

A tunnel microtract organ for T cell progenitor homing is formed by neural crest morphogenesis via Sox10-Cdc42 axis

The paper identifies a tunnel microtract (TMT) as a neural crest-derived organ essential for T cell progenitor homing, showing Sox10-Cdc42 signaling drives its formation in zebrafish and mice.

Structure and genomic organization of the human DUX4 homologue bovine DUXC

The paper provides the full-length sequence of DUXC mRNA from bovine embryos and investigates its genomic organization and expression patterns.

Measuring developmental information encoded by a dynamicallandscape

The paper estimates the information content of developmental landscapes in two systems by integrating developmental biology, information theory, and dynamical systems.

Temporal Gatekeeping Role of Lmx1 during chordate neural tube morphogenesis

This paper investigates the role of Lmx1 in Ciona neural tube closure, finding that its knockdown causes defects and overexpression disrupts cell intercalation, suggesting a conserved role in chordate morphogenesis.

Stepwise GRN co-option in the evolution of a dipteran respiratory organ

This study investigates how gene regulatory network co-option drove the evolution of a dipteran respiratory organ through ecological and evolutionary changes.

Transcriptional and cellular maturation of the chick spinal cord in the context of distinct neuromuscular circuits

The paper studies the transcriptional and cellular maturation of the chick spinal cord at single-cell resolution, revealing similar cell type repertoires for wings and legs and limited transcriptional changes with spatially restricted plasticity in motor neurons.

Single-cell transcriptomic profiling of C. elegans Q neuroblast lineage during migration and differentiation

The paper uses single-cell RNA sequencing to map the transcriptomic changes in the C. elegans Q neuroblast lineage during migration and differentiation, identifying novel genes and Wnt-related mechanisms.

Transcriptome comparison between the cultured and in vivo Chick Primordial Germ Cells by SMART-seq-based single cell RNA sequencing

This study compares transcriptomes of cultured and in vivo chicken primordial germ cells using single-cell RNA sequencing, revealing shifts in gene regulatory networks and new intermediate cell states.

A Single-Cell Transcriptomic Atlas of Symmetry Breaking Across Eutherian Mammals

This study creates a single-cell RNA sequencing atlas of sheep embryos to understand symmetry breaking and identifies conserved and species-specific molecular programs across eutherian mammals.

Eigengene reveals invariant global spatial patterns across mouse and fish brain development

The paper shows that the eigengene, the principal component of gene expression, maintains an invariant global spatial pattern across mouse and zebrafish brain development, suggesting evolutionary conservation and a lineage-based explanation.

Boundary-guided cell alignment drives mouse epiblast maturation

This study identifies how tissue boundaries guide cell orientation and lumen formation during mouse epiblast maturation.

A Mediator-dependent hypertranscriptional program governs neural stem cell fate decisions in vivo

This study identifies the Mediator complex as a key regulator of hypertranscription in Drosophila neural stem cells, showing its necessity for proper differentiation and stem cell fate.

Divergent mechanics of inner ear morphogenesis are coupled to developmental tempo over vertebrate evolution

The paper examines inner ear morphogenesis across 12 vertebrate species, finding that divergent mechanical processes in tissue expansion are coordinated with developmental tempo to maintain conserved morphology.

Expanding the fly eye gene regulatory network: from Drosophila to the hoverfly Episyrphus balteatus.

The paper compares the gene regulatory network of compound eye development between Drosophila and Episyrphus balteatus, finding conserved and species-specific regulatory interactions.

Synthetic reconstitution of planar polarity initiation reveals collective migration as a symmetry-breaking cue

The paper reconstitutes planar polarity initiation in an engineered epithelial system, showing collective migration breaks symmetry and drives polarity across scales.

A Phospho-Switch for Cell Fate Control

The paper identifies a phospho-switch in SALL4 that controls cell fate by modulating BAF complex interaction in response to BMP4-DUSP9 signaling, causing developmental defects when disrupted.

Actomyosin active torques determine body plan handedness in C. elegans

The paper shows that reversing active chiral torques in C. elegans leads to mirrored embryos and situs inversus, demonstrating their role in determining body plan handedness.