Developmental Biology and Gene Regulation

Long-Range Coupling of Posterior Cell Addition and Anterior Vacuolation Provides Robustness in Notochord Elongation.

The paper models how progenitor addition and vacuolation interact in zebrafish notochord development, showing a feedback mechanism that maintains tissue proportions during elongation.

Prdm16 amplifies Notch signaling and suppresses venous lineage specification to prevent arteriovenous malformations during vascular development

This study shows Prdm16 enhances Notch signaling in arterial endothelial cells and suppresses venous fate to prevent arteriovenous malformations in zebrafish and human cells.

A switch in collagen expression regulates cessation of distal tip cell migration in C. elegans

The paper identifies a collagen expression switch in C. elegans distal tip cells that regulates migration cessation during gonad development.

Enrichment of neural crest cells by antibody labelling and flow cytometry for single-cell transcriptomics in a lizard

The paper presents a method to enrich neural crest cells in lizards using antibody labelling and flow cytometry, validated through single-cell RNA sequencing.

Vesicular glutamate release is necessary for neural tube formation

This study shows that vesicular glutamate release via VGluT1 is essential for neural tube formation in Xenopus laevis embryos, as its disruption leads to neural tube defects.

Evidence that injury can cause Drosophila gut differentiated, polyploid enterocytes to be recruited as stem cells via paligenosis

The paper shows that injured Drosophila gut polyploid enterocytes dedifferentiate into diploid progenitors via paligenosis, involving autophagy and TORC1.

Morphological innovation without gene co-option: the Drosophila sex comb evolved via changes in developmental tempo and energy metabolism

This study shows that the Drosophila sex comb evolved through changes in developmental tempo and energy metabolism, not by co-opting new genes into downstream networks.

Dynamic and non-uniform expression of key transcription factors provides novel insights into the emergence of neural crest cells at the neural plate border

The paper uses HCR-FISH to study spatiotemporal dynamics of neural crest gene expression in Xenopus embryos and identifies regulatory relationships between key transcription factors.

Germline Blastomeres transcriptomics in the presence or absence of PIE-1 during C. elegans early embryogenesis

The paper uses transcriptomics to study PIE-1's role in maintaining germline identity in C. elegans embryos by comparing somatic and germline blastomeres with and without PIE-1.

Actinotrichia-independent developmental mechanisms of spiny rays facilitate the morphological diversification of Acanthomorpha fish fins

This study shows that spiny-ray development in fish is independent of actinotrichia, enabling morphological diversification through osteoblast distribution and signaling molecule intensity.

Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the Drosophila embryo

The paper quantifies Dorsal/NF-κB mobility and DNA binding along the dorsal-ventral axis of Drosophila embryos, revealing a gradient in DNA binding that affects gradient formation and downstream gene expression.

Start Small: A Model for Tissue-wide Planar Cell Polarity without Morphogens

This paper develops a computational model showing how tissue-wide planar cell polarity can emerge without global morphogen gradients by using local signals and small initial tissue size.

High resolution spatial transcriptomic and proteomic profiling of early primate gastrulation in utero

The paper provides a high-resolution spatial transcriptomic and proteomic map of early primate gastrulation, identifying key cell populations and signaling networks.

Directional alignment of different cell types organizes planar cell polarity

The paper shows directional alignment of cell types helps maintain planar cell polarity in tissues with multiple cell types.

The rewiring of a terminal selector regulatory cascade generates convergent neuronal laterality

The paper identifies miRNA-mediated regulatory mechanisms that generate left-right neuronal asymmetry in Pristionchus pacificus by rewiring terminal-selector networks.

Developmental system drift in the patterning of the arthropod tarsus

This study investigates the functional role of clawless in harvestman tarsus development and suggests developmental system drift in arthropod appendage patterning.

Ancient origin of the dorso-ventral patterning system of vertebrate paired fins

This study shows that dorso-ventral patterning genes in paired fins are conserved in median fins, supporting an ancient origin of the DV regulatory module that was redeployed during paired fin evolution.

Toll receptors mediate tissue intrinsic surveillance against aberrant cells by detecting cell fate aberrations

This study identifies long Toll receptors as mediators of interface surveillance in Drosophila wing imaginal discs, detecting cell fate aberrations through expression level differences between neighboring cells.

Determinants of the Transition Zone Width of Morphogen Readouts

The paper challenges the traditional view that morphogen concentration fluctuations determine transition zone width, showing instead that cellular readout noise is the key factor.

Somatic gene repression ensures physical segregation of germline and soma in Drosophila embryos

The paper shows that somatic gene silencing in Drosophila germline is essential for maintaining physical segregation from soma, preventing cell death and ensuring germline viability.

Identification of the protein precursor for thyroid hormone synthesis in the basal chordate ascidian Styela clava

This study identifies the thyroid hormone (TH) precursor protein in the ascidian Styela clava, demonstrating endogenous TH synthesis and evolutionary conservation of the TG protein function.

Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe

This study shows Bmp9 upregulates Lunatic Fringe in endothelial cells, enhancing Notch signaling and regulating angiogenesis dynamics.

PRDM16 is necessary for sensory neuronal development in the Trigeminal Ganglion

This study shows PRDM16 is essential for trigeminal ganglion development and sensory neuron differentiation in zebrafish and mice.

Single-cell multiomics identifies key nodes and cis-regulatory elements of the networks specifying the eye domains in zebrafish

The paper uses single-cell multiomics to identify key regulatory nodes and cis-regulatory elements in zebrafish eye development.

MYRF drives heterochronic miRNAs and LIN-42, and amplifies oscillatory programs for stage transitions

This study identifies MYRF as a master temporal regulator in C. elegans larval development, showing it drives oscillatory gene networks and stage transitions through microRNA activation and feedback loops.

NR6A1 is essential for neural crest cell specification, formation and survival

This study identifies NR6A1 as a critical regulator of mammalian neural crest cell specification, formation, and survival through loss-of-function experiments and multiomic analyses.

The endoderm cell trajectory of urochordate Styela clava reveals the dual developmental origin and evolution of digestive tract

This study uses single-cell RNA sequencing to trace endoderm cell trajectories in Styela clava, revealing dual origins of the digestive tract and conserved regulatory programs across chordates.

Notch signalling plays a critical role in patterning the ventral mesoderm during early embryogenesis in Drosophila melanogaster

The paper investigates the role of Notch signaling in ventral mesoderm patterning during early Drosophila embryogenesis and identifies genes regulated by this pathway.

An APP-centered molecular gateway integrates innate immunity and retinoic acid signaling to drive irreversible metamorphic commitment

The paper identifies a signaling cascade in sea star metamorphosis that links innate immunity and retinoic acid signaling through an APP-centered module, with implications for human neurological disorders.

The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress

The paper identifies a flow-specific Notch1 mechanotransduction pathway involving receptor polarization, endocytosis, and proteolytic activation in response to fluid shear stress.