Circadian rhythm and melatonin

Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytes

This study identifies circadian rhythmic transcripts in mouse astrocytes and shows that circadian regulation of ER Ca2+ release affects gap junction communication and synaptic activity.

Efficacy and Specificity of Melanopsin Reporters for Retinal Ganglion Cells

The paper evaluates melanopsin reporter systems for labeling retinal ganglion cells and finds no method labels all and only intrinsic photosensitive retinal ganglion cells.

Investigating the Synergistic Role of GCN2 and HPA Axis in Regulating Integrated Stress Response in the Central Circadian Timing System

This study investigates the interaction between the circadian system and integrated stress response through a mathematical model, showing GCN2's role in linking ISR with circadian rhythms and its impact on re-entrainment after jetlag.

The Circadian Neuropeptide PDF has Sexually Dimorphic Effects on Activity Rhythms

This study shows that female Drosophila circadian rhythms are less affected by mutations in the PDF pathway compared to males, suggesting greater resilience in female circadian timekeeping.

Nutrient Abundance Signals the Changing of the Seasons by Phosphorylating PER2

The paper shows that high fat diet affects circadian entrainment to summer and winter photoperiods through PER2 phosphorylation and polyunsaturated fatty acids.

Synchronization of Human Circadian Genes Between in vivo and Cultured Blood Samples

This study shows that culturing blood samples and measuring circadian gene expression correlates more closely with in vivo samples than non-circadian genes, validating a minimally invasive method for circadian analysis.

Diurnal variation of brain activity in the human suprachiasmatic nucleus

This study investigates diurnal variation in human SCN activity using perfusion imaging, finding higher activity at noon and lower in the early morning, aligning with rodent patterns under light conditions.

Intrinsic skeletal muscle function and contraction-stimulated glucose uptake do not vary by time-of-day in mice

This study shows that intrinsic skeletal muscle function and contraction-stimulated glucose uptake in mice do not vary across the 24-hour circadian cycle.

A comparative study of algorithms detecting differential rhythmicity in transcriptomic data

This study compares seven algorithms for detecting differential rhythmicity in transcriptomic data, finding high overlap in results but differences in output numbers and parameters.

Parametric modeling of mechanical effects on circadian oscillators

This paper extends a biochemical model of circadian rhythms to include mechanical effects, showing that mechanical signals must be within an optimal range for oscillations to occur.

Melatonin suppression by light involves different retinal photoreceptors in young and older adults

This study shows that light suppresses melatonin differently in young and older adults, with young adults relying solely on melanopsin and older adults involving L-cones as well.

Method to determine whether sleep phenotypes are driven by endogenous circadian rhythmicity or environmental light by combining longitudinal data and personalised mathematical models

This paper introduces a model to distinguish between endogenous and exogenous factors affecting sleep timing using longitudinal data and personalized mathematical modeling.

Effects of calibrated blue-yellow (-S+) changes in light on the human circadian clock

This study investigates the impact of blue-yellow light changes on the human circadian clock and sleep, finding no significant effects under moderate light levels.

Mammalian circadian clock proteins form dynamic interacting microbodies distinct from phase separation

The paper shows that endogenous circadian clock proteins form dynamic microbodies distinct from phase separation condensates, suggesting an enzyme-like mechanism in the circadian feedback loop.

LimoRhyde2: genomic analysis of biological rhythms based on effect sizes

LimoRhyde2 analyzes genomic data to identify rhythmic genes by focusing on effect sizes rather than statistical significance, revealing genes with high-amplitude rhythms.

TARANIS interacts with VRILLE and PDP1 to modulate the circadian transcriptional feedback mechanism in Drosophila

This study identifies TARANIS as a novel regulator of the Drosophila circadian clock by enhancing the transcriptional activity of VRILLE and PDP1.

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

This study shows that P2-HNF4 regulates ketogenesis in the liver and is involved in circadian metabolism, with implications for gender-specific ketone body levels.

Desynchronized Somas and Terminals in a Morning Clock Neuron: Presynaptic Ca2+ Spiking and Native Neuropeptide Release Peak As Somatic Ca2+ Declines

The paper investigates the timing mismatch between somatic Ca2+ activity and neuropeptide release in Drosophila sLNv neurons, finding that terminal Ca2+ spiking and neuropeptide release peak midmorning, hours before their behavioral effects.

Mapping the daily rhythmic transcriptome in the diabetic retina

This study examines how diabetes affects the daily rhythmic gene expression in retinas, finding phase shifts in the transcriptional cycle linked to metabolic and hypoxia pathways.

Impact of light on task-evoked pupil responses during cognitive tasks.

This study examines how different light levels affect task-evoked pupil responses during cognitive tasks, finding that higher light levels increase pupil dilation in response to auditory stimuli.

The neurons that drive infradian sleep-wake and mania-like behavioral rhythms

This study shows that methamphetamine exposure in mice induces infradian locomotor rhythms and mania-like behaviors, which depend on dopamine neurons projecting to the nucleus accumbens.

Effects of lithium on locomotor activity and circadian rhythm of honey bees

This study examines how lithium affects honey bee locomotor activity and circadian rhythms, finding that it alters activity levels and disrupts circadian patterns, similar to its effects in bipolar disorder treatment.

Melanopsin activates divergent phototransduction pathways in ipRGC subtypes

This study resolves conflicting models of melanopsin phototransduction in ipRGC subtypes, showing HCN channels are dispensable in M4 and M2, with TRPC and T-type calcium channels playing key roles.

Cold-induced Suspension and Resetting of Ca2+ and Transcriptional Rhythms in the Suprachiasmatic Nucleus Neurons

This study shows that SCN neurons maintain circadian rhythms at moderate hypothermia but suspend them at deep hypothermia, with Ca2+ rhythms resetting faster than transcriptional rhythms upon rewarming.

Impact of repeated short light exposures on sustained pupil responses in an fMRI environment

The paper investigates how repeated short light exposures affect sustained pupil responses during different cognitive tasks, finding that higher melanopic irradiance increases pupil responses and that task context influences variability.

Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycle

This study uses isotope tracing to show rhythmic glucose metabolism in Drosophila, revealing internal mechanisms controlling metabolic homeostasis across day and night.

The Drosophila Circadian Clock Gene Cycle Controls Development of Clock Neurons

This study shows that the Drosophila circadian gene cycle (cyc) has a non-circadian role in the development of clock neurons, affecting fasciculation and morphology.

Temperature-driven coordination of circadian transcriptome regulation

The paper analyzes bulk RNA sequencing data from Drosophila fat bodies under different temperatures to show temperature-dependent circadian transcriptome changes and gene coordination.

Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment among Eastern Indians

The paper identifies genetic variants and expression changes in circadian genes and BDNF associated with post-stroke cognitive impairment in Eastern Indians.

Spatio-temporal dynamics of nuclear CREB1: what does it mean?

This study examines the spatio-temporal dynamics of nuclear CREB1 in rat pinealocytes, finding that its distribution varies across time and cell types, with increased dispersion at night.