Circadian rhythm and melatonin

Novel clock neuron subtypes regulate temporal aspects of sleep

The paper identifies novel clock neuron subtypes in Drosophila that regulate sleep timing through distinct projection patterns and a common receptor.

A subclass of evening cells promotes the switch from arousal to sleep at dusk

This study identifies E1 neurons in Drosophila that regulate the transition from arousal to sleep at dusk through light-dependent mechanisms.

Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development

This study shows that nutritional status in Drosophila larvae drives the development of sleep-wake rhythms and memory circuits by influencing glucose metabolism and neuronal activity.

Targeting circadian transcriptional programs in triple negative breast cancer through a cis-regulatory mechanism

This paper identifies a cis-regulatory mechanism in triple-negative breast cancer where targeting circadian transcription factors with small molecules represses a circadian transcriptional program, offering a new therapeutic strategy.

The formation of a fuzzy complex in the negative arm regulates the robustness of the circadian clock.

The paper identifies a fuzzy complex formed by negative-arm proteins that regulates the robustness of the circadian clock through electrostatic interactions and conserved motifs.

Genetic tuning of intrinsically photosensitive retinal ganglion cell subtype identity to drive visual behavior

This study identifies Brn3b as a key transcription factor regulating ipRGC subtype identity and their associated visual behaviors in mice.

Proteomic Insights into Circadian Transcription Regulation: Novel E-box Interactors Revealed by Proximity Labeling

The paper identifies novel E-box interactors using proximity labeling proteomics in mouse fibroblasts, revealing proteins involved in circadian transcription regulation.

A new Opn4cre recombinase mouse line to target intrinsically photosensitive retinal ganglion cells (ipRGCs)

The paper introduces an improved Opn4cre mouse line for selectively targeting ipRGCs, showing higher specificity and distinct labeling patterns compared to existing lines.

GLMMcosinor: Flexible Cosinor Modeling to Characterize Rhythmic Time Series Using a Generalized Linear Mixed Modeling Framework

GLMMcosinor extends cosinor analysis to non-Gaussian and hierarchical data using GLMM, enabling more flexible rhythmic time series modeling.

The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian function in vivo

This study shows that Fn14, a cytokine receptor, acts as a molecular brake on neuronal activity in adult mice, influencing circadian rhythms, sleep, and memory.

Circadian control of a sex-specific behaviour in Drosophila

This study identifies Cry+ LNd neurons as essential for the circadian control of egg-laying in Drosophila females, revealing their role through neural connectivity analysis.

Circadian control in the timing of critical periods during Drosophila larval neuronal development.

This study identifies a circadian mechanism controlling critical periods in Drosophila larval neuronal development, showing that light manipulation can alter these periods and induce seizures.

The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment in the mouse

The paper shows that the molecular clock in the SCN is necessary but not sufficient for fear entrainment in mice, leading to mistimed circadian behavior.

Circadian dynamics of the Zbtb14 protein in the ventral hippocampus are disrupted in epileptic mice

This study examines circadian Zbtb14 protein dynamics in the hippocampus of epileptic mice, finding disrupted oscillations and altered gene regulation.

Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock in Drosophila

The paper identifies receptor tyrosine kinase (RTK) signaling as a mechanism coupling the central and peripheral circadian clocks in Drosophila, showing multiple RTKs contribute to circadian rhythm synchronization.

Astrocytes in the mouse suprachiasmatic nuclei respond directly to glucocorticoids feedback

The paper shows adult mouse SCN astrocytes respond to glucocorticoids through GR activation, influencing circadian rhythms and highlighting astrocytic roles in time-keeping.

TimeTeller: a tool to probe the circadian clock as a multigene dynamical system

TimeTeller estimates circadian clock function from single transcriptomes by modeling the multi-dimensional state of the clock, demonstrating its application across species and data types.

PDF neuropeptide signals independently of Bruchpilot-labelled active zones in daily remodelled terminals of Drosophila clock neurons

The paper investigates the relationship between PDF release and BRP-labelled active zones in Drosophila clock neurons, finding that PDF release is independent of BRP-organised active zones during circadian plasticity.

The Emergence of Circadian Timekeeping in the Intestine

This study tracks the emergence of the circadian clock in Drosophila intestine cells, showing it begins after development and is influenced by hormone signaling and stem cell differentiation.

Power analysis for human melatonin suppression experiments

This paper presents a Bayesian framework and Shiny app for power analysis in melatonin suppression experiments, accounting for individual variability and experimental parameters.

Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish

This study investigates the role of the eye and opn4xa in circadian photoentrainment in zebrafish, showing the eye is largely dispensable for circadian rhythms but contributes to phase shifts, while opn4xa has limited effects on locomotor activity rhythms.

Hypoxia disrupts circadian rhythms in astrocytes and causes synapse engulfment defects

This study shows hypoxia disrupts astrocytic circadian rhythms, reducing synaptosome phagocytosis and linking this to ASD-related synapse defects.

Circadian clocks in human cerebral organoids

This study demonstrates circadian rhythms in human brain cells and organoids, showing they are temperature-compensated and modulated by drugs and cortisol, with implications for chronobiology and brain health.

Gene expression plasticity of the mammalian brain circadian clock in response to photoperiod

The paper investigates how photoperiod affects SCN gene expression in mice, identifying key genes and pathways involved in circadian plasticity.

A multiscale model of the mammalian liver circadian clock supports synchronization of autonomous oscillations by intercellular communication.

The paper develops a multiscale model of the mammalian liver circadian clock to show that intercellular communication is necessary for sustained circadian oscillations with a near 24-hour period.

Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock

This study shows that Cdk5 activity, modulated by light, gates rapid circadian phase shifts by regulating calcium influx and signaling pathways in SCN neurons.

Lack of rhythmicity in Bmal1 deficient mice impairs motivation towards natural stimuli.

This study shows that Bmal1 deficiency disrupts circadian rhythms and alters reward-related gene expression, leading to increased motivation for natural rewards in mice.

Mathematical analysis of light-sensitivity related challenges in assessment of the intrinsic period of the human circadian pacemaker

This paper presents a mathematical analysis of light-sensitivity challenges in assessing the human circadian pacemaker's intrinsic period, showing that dim light may affect results more than previously thought.

Circadian rhythmicity and photobiological mechanisms of light sensitivity and discomfort glare in humans

This study shows that light-induced discomfort glare has a circadian rhythm with peak sensitivity at night and minimal in the afternoon, driven by ipRGCs and cones, with a phase lag between photoreceptor sensitivity and discomfort.

Coordination of rhythmic RNA synthesis and degradation orchestrates 24-hour and 12-hour RNA expression patterns in mouse fibroblasts

The paper investigates how rhythmic RNA synthesis and degradation contribute to 24-hour and 12-hour RNA expression patterns in mouse fibroblasts, finding synthesis drives 24-hour rhythms and degradation drives 12-hour rhythms.