Microtubule and mitosis dynamics

Asymmetric Binomial Statistics Explains Organelle Partitioning Variance in Cancer Cell Proliferation

The paper measures asymmetric organelle partitioning in cancer cells and finds mitochondria and membrane lipids are asymmetrically distributed and correlated with cytoplasm apportioning.

Msps Governs Acentrosomal Microtubule Assembly and Reactivation of Quiescent Neural Stem Cells

This study identifies Msps/XMAP215 as a regulator of acentrosomal microtubule assembly in quiescent Drosophila NSCs, which is essential for E-cadherin localization and NSC reactivation.

Traip Mitotic Function Controls Brain Size

The paper shows that Traip function during mitosis is critical for proper brain size in Drosophila, as its loss causes neuronal loss due to mitotic defects.

Trans-generational inheritance of centromere identity requires the CENP-A N-terminal tail in the C. elegans maternal germ line

The paper shows that the N-terminal tail of CENP-A is required for de novo centromere establishment in C. elegans germ line but not for maintenance during embryogenesis.

Tumour Suppressor Parafibromin/Hyrax Governs Cell Polarity and Centrosome Assembly in Neural Stem Cells

This study shows that Parafibromin/Hyrax regulates cell polarity and centrosome assembly in neural stem cells, preventing overgrowth and tumour formation.

A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding

The paper identifies a release-and-capture mechanism involving Katanin and Patronin that generates a non-centrosomal microtubule array essential for tube budding in Drosophila salivary glands.

Microtubule Disruption does not Impair Learning in the Unicellular Organism Paramecium: Implications for Information Processing in Microtubules

This study tests whether microtubules are involved in learning in Paramecium by disrupting microtubular dynamics and observing learning behavior.

UNC-45A is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

The paper identifies UNC-45A expression in proliferative cells of the mouse genital tract and microtubule-rich areas of the nervous system, suggesting its potential role in ovarian cancer and neurodegeneration.

The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals a new Arpp19/PP2A-B55 feedback loop

This study identifies molecular determinants controlling Arpp19 phosphatase-inhibitory activity and reveals a feedback loop between two phosphorylation sites.

A midbody component homolog, too much information/prc1-like, is required for microtubule reorganization during both cytokinesis and axis induction in the early zebrafish embryo

This study shows that zebrafish prc1l is essential for microtubule reorganization during cytokinesis and axis induction in early embryos.

Acetylated microtubules are required for maintenance of the barrier between two adjacent tissues

This study shows that microtubule acetylation is required for maintaining the barrier between adjacent tissues during oogenesis in Drosophila.

Short stop is a gatekeeper at the ring canals of Drosophila ovary

This study shows that Short stop (Shot) directs material flow from nurse cells to the oocyte by organizing microtubule tracks and controlling transport directionality through ring canals.

APC/C-Vihar regulates centrosome activity and stability in the Drosophila germline

This study shows that APC/C-Vihar regulates centrosome stability and migration in Drosophila germline, affecting female fertility through PCM protein accumulation and centriole integrity.

Meiosis-Specific Cohesin Complexes Display Distinct and Essential Roles in Mitotic ESC Chromosomes

This study identifies distinct roles of meiosis-specific cohesin complexes in ESCs, showing their essential functions in chromosome structure and mitotic processes.

Parental genome unification is highly erroneous in mammalian embryos

The paper identifies an error-prone mechanism of parental genome unification in bovine embryos that leads to aneuploidy, with defects in nucleolar clustering correlating with embryo development failure.

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

This study shows that DIAPH3 deficiency causes mitotic errors, neurogenesis defects, and brain dysfunction by disrupting microtubule dynamics and associated proteins.

Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose

The paper shows that cell competition eliminates segmentally aneuploid cells in Drosophila imaginal discs through the RpS12-Xrp1 pathway, dependent on differences in ribosomal protein gene dose.

Cytokinetic abscission is part of the mid-blastula transition switch in early zebrafish embryogenesis

The paper shows that abscission is delayed in early zebrafish embryos until midblastula transition, allowing sibling cells to remain connected and coordinate developmental timing.

Cryo-EM reveals the complex architecture of dynactin's shoulder and pointed end

The paper uses cryo-EM to determine the structure of dynactin's shoulder and pointed end, revealing their architecture and subunit interactions.

Oocyte spindle assembly depends on multiple interactions between HP1 and the CPC

The paper investigates the role of HP1 and CPC interactions in Drosophila oocyte spindle assembly and identifies their involvement in kinetochore formation and chromosome bi-orientation.

Gradual centriole maturation associates with the mitotic surveillance pathway in mouse development

The paper shows that centriole maturation in mouse embryos is linked to a mitotic surveillance pathway involving 53BP1, USP28, and p53, which becomes active around E7.

The role of gene dosage in budding yeast centrosome scaling and spontaneous diploidization

The paper investigates how gene dosage affects centrosome scaling and diploidization in budding yeast, linking ploidy changes to structural incompatibilities and evolutionary adaptations.

Impact of evolutionary selection on dynamic behavior of MCAK protein

This study examines how evolutionary selection in MCAK protein affects its dynamic behavior related to microtubule binding and stability.

The centriolar satellite protein Cfap53/Ccdc11 facilitates the formation of the first zygotic microtubule organizing center in the zebrafish embryo.

This study shows that Cfap53 is essential for forming the first zygotic microtubule organizing center in zebrafish embryos, but not for later cell divisions.

The coordinated localization of mRNA to centrosomes facilitates error-free mitosis

The paper investigates mRNA localization to centrosomes in Drosophila embryos, identifying FMRP's role in regulating centrosomal RNA and its impact on spindle formation and genome stability.

Discovery of Alstrom syndrome gene as a regulator of centrosome duplication in asymmetrically dividing stem cells in Drosophila.

The paper identifies Alms1a as a regulator of centrosome duplication in asymmetrically dividing Drosophila stem cells and shows its specific requirement in this process.

Wwc2 is a novel cell division regulator during preimplantation mouse embryo lineage formation and oogenesis

This study identifies Wwc2 as a regulator of cell division during mouse preimplantation embryo development and oogenesis, showing its role in maintaining cell number and division fidelity.

Amitosis as a strategy of cell division - Insight from the proliferation of Tetrahymena thermophila macronucleus

The paper investigates amitosis in Tetrahymena thermophila macronuclei, showing chromosomal replication patterns and non-random fission strategies.

The microtubule organization in the zebrafish yolk adapts to transgene-mediated phenotypic variations

The paper studies microtubule organization in zebrafish yolk using dclk2-GFP embryos and Light Sheet Fluorescence Microscopy, finding that MTOC dynamics are variable and not rigid.

Multiple pools of Protein Phosphatase 2A-B56 function to antagonize spindle assembly, promote kinetochore attachments and maintain cohesion in Drosophila Oocytes

The paper identifies the role of PP2A-B56 subunit in Drosophila oocytes, showing its necessity for sister chromatid cohesion, microtubule attachment, and metaphase I arrest during meiosis.