Herpesvirus Infections and Treatments

Spatiotemporal dynamics of alphaherpesviral latency and reactivation in the murine central nervous system

This study maps the spatiotemporal dynamics of alphaherpesviral latency and reactivation in the CNS using a modified PrV in mice, identifying key brain regions as viral reservoirs.

ATRX promotes transcription initiation of HSV-1 immediate early genes during early lytic infection

This study shows ATRX promotes HSV-1 immediate early gene transcription by preventing G-quadruplex formation during early infection.

Equine herpesvirus myeloencephalopathy-related mutations in EHV-1 DNA polymerase allow EHV-1 to grow at elevated temperatures

The paper shows that EHV-1 strains with specific mutations in the DNA polymerase gene can replicate at elevated temperatures, linking these mutations to EHM.

Time-Resolved Mapping in Calves Reveals BoHV-1 Shift From Mucosal Replication to Trigeminal Neuroinvasion and IFN-α-bPML Antagonism

This study maps BoHV-1 infection in calves, showing a shift from mucosal replication to neuroinvasion and identifies PML's dual role in antiviral defense and viral antagonism.

Optimisation of lytic herpes simplex virus infection in human induced pluripotent stem cell derived cortical neurones

This study optimizes HSV-1 infection in human iPSC-derived cortical neurones, enabling efficient and synchronous infection for microscopy and biochemical analysis.

The producer cell type of HSV-1 alters the proteomic contents and infectious capacity of virions

This study shows that HSV-1 producer cell type affects virion protein composition and infectious capacity.

An effective primary and memory CD8+ T cell response is directed towards an H-2Kb restricted HSV1-gB-SSIEFARL epitope in the experimentally infected zebrafish

This study identifies and characterizes HSV1-specific CD8+ T cells in zebrafish, showing an effective primary and memory response to an H-2Kb restricted epitope.

N-myristoyltransferase Inhibitors as Candidate Broad-Spectrum Antivirals to Treat Viral Infections Promoted by Immunosuppression Associated with JAK Inhibitors Therapy

This study shows NMT inhibitors remain effective against viruses like HSV-1 even when JAK inhibitors like ruxolitinib are present, suggesting their use in treating immunosuppression-related viral infections.

Neurotropic and non-neurotropic equid alphaherpesvirus 1 (EHV1) mobilize most histones within viral replication compartments

This study shows that both neurotropic and non-neurotropic EHV1 strains mobilize most histones within viral replication compartments, suggesting a common mechanism to prevent chromatin-mediated genome silencing.

Alphaherpesvirus pUL21 homologues use non-canonical motifs to compete with cellular adaptors for protein phosphatase 1 binding

This study identifies non-canonical TROPPO motifs in alphaherpesvirus proteins that compete with cellular adaptors for PP1 binding, revealing a novel mechanism of PP1 recruitment.

Structure of a new capsid form and comparison with A-, B- and C-capsids clarify herpesvirus assembly and DNA translocation

This study identifies a new D-capsid type in herpesvirus assembly, revealing structural dynamics of DNA translocation and clarifying the origins of empty and DNA-filled capsids.

Generation, characterization and exploiting caprine herpesvirus 1 secreted glycoprotein D

This study characterizes CpHV-1 glycoprotein D, generates a secreted version, and demonstrates its potential for diagnostic and immunization applications.

Structural insights into DNA annealing and recombination by herpesviral DNA-binding proteins ICP8 and BALF2

This paper presents the structures of herpesviral DNA-binding proteins ICP8 and BALF2 in DNA complexes, revealing mechanisms of DNA annealing and recombination.

Genital herpes shedding episodes associate with alterations in the spatial organization and activation of mucosal immune cells

This study examines how HSV-2 shedding affects immune cell organization and gene expression in the vaginal mucosa, finding increased immune surveillance and potential tissue homeostasis mechanisms.

HSV-1 orchestrates host RAP80 ubiquitination by ICP0 and UL36USP to promote viral survival

This study identifies RAP80 as a target of HSV-1 ubiquitination enzymes ICP0 and UL36USP, showing how HSV-1 modulates host proteins at different infection stages to promote its survival.

Neutralizing Activity of Cervicovaginal Secretions against Herpes Simplex Virus is Mediated by Mucosal IgG and Viral Glycoprotein E and Adversely Impacted by Vaginal Dysbiosis

This study shows that cervicovaginal secretions neutralize HSV through mucosal IgG and gE interactions, which are reduced in bacterial vaginosis due to glycan loss.

Intracellular and extracellular dynamics of herpes simplex virus 1 DNA and infectious particles in epithelial and neuronal cells

This study models HSV-1 dynamics in epithelial and neuronal cells under low and high MOI, revealing differences in eclipse phase duration, egress rates, and productive infection kinetics.

Tissue-Targeted Prime/Pull/Keep Therapeutic Herpes Simplex Virus Vaccine Protect Against Recurrent Ocular Herpes Diseases in HLA-A*0201 Transgenic Rabbits

This study tests a prime/pull/keep HSV-1 vaccine in HLA-A*0201 transgenic rabbits, showing it reduces corneal herpes infection by mobilizing and retaining CD8+ T cells in infected tissues.

Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency

This study shows ICP34.5 sustains HSV-1 latency in human neurons by maintaining host translation, with distinct mechanisms in human iPSC-derived neurons versus mouse primary neurons.

A multiplex real-time PCR assay for detection of equine herpesvirus 1 and equine herpesvirus 4

This paper develops and validates a multiplex real-time PCR assay for simultaneous detection of EHV-1 and EHV-4 in horses, showing improved specificity and 100% concordance with singleplex assays.

BAF chromatin remodeling complexes inhibit immediate-early and early, but not late, transcription of herpes simplex virus 1

This study shows BAF chromatin remodeling complexes inhibit HSV-1 immediate-early and early transcription but not late transcription or DNA replication during lytic infection.

Herpes Simplex Virus 1 Envelope Glycoprotein C Shields Glycoprotein D to Protect Virions from Entry-Blocking Antibodies

This study shows HSV-1 gC shields gD from neutralizing antibodies, increasing viral susceptibility to antibody neutralization when gC is absent.

The loss of both pUL16 and pUL21 in HSV-1 infected cells abolishes cytoplasmic envelopment.

This paper shows that simultaneous loss of pUL16 and pUL21 in HSV-1 infected cells prevents cytoplasmic envelopment of viral capsids.

LAVR-289, a new acyclo-nucleoside phosphonate having broad-spectrum activity against herpesviruses.

This study evaluates LAVR-289, a new antiviral compound, showing broad-spectrum activity against herpesviruses and resistance to existing treatments.

Herpes Simplex Virus Assembly and Spread in murine skin after infection from the outside

This paper develops a novel murine ex vivo skin explant model to study HSV-1 infection and spread in intact skin, showing HSV-1 exclusively spreads in the epidermis through infected keratinocytes.

Complex Human hear bearing Skin Organoids reveal Cell Type Specific Susceptibility and Innate Immune Responses to Herpes Simplex Virus 1

This study uses human hair-bearing skin organoids to investigate HSV-1 infection and host responses, revealing cell-type-specific susceptibility and spatially organized immune reactions.

Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition

This study investigates VZV gene repression in neuronal cells, finding that histone deposition is absent at quiescent viral genomes.

Dissecting the role of RNA-binding proteins in early herpes simplex virus 1 transcription using acute protein depletion

The paper investigates the role of five RNA-binding proteins in HSV-1 transcription and their impact on viral replication, finding that SPT5 is essential for immediate-early gene expression while SFPQ has a different regulatory role.

Asymptomatic neonatal herpes simplex virus infection in mice leads to long-term cognitive impairment

This study shows that asymptomatic neonatal HSV infection in mice causes long-term cognitive impairment, highlighting the role of the γ34.5 gene in neurovirulence.

Interferon Dependent Immune Memory during HSV-1 Neuronal Latency Results in Increased H3K9me3 and Restriction of Reactivation by ATRX

This study shows that interferon-induced H3K9me3 and ATRX restrict HSV-1 reactivation by maintaining epigenetic memory during neuronal latency.