Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Differential regulation of mouse hippocampal gene expression sex differences by chromosomal content and gonadal sex

The paper investigates how chromosomal content and gonadal sex influence gene expression and DNA modification patterns in mouse hippocampi, revealing sex chromosome-specific regulatory effects.

Silencing XIST on the future active X: Searching human and bovine preimplantation embryos for the repressor

The paper investigates XIST repression on the future active X in human and bovine preimplantation embryos using single-cell RNA sequencing and qRT-PCR, identifying potential repressors and timing of XIST expression.

Extreme variation in recombination rate and genetic variation along the Sylvioidea neo-sex chromosome

The paper maps recombination rates and genetic variation along the Z chromosome of great reed warblers, revealing extreme recombination variation and its impact on diversity and repeats.

A comparison of methodological approaches to the study of young sex chromosomes: A case study in Poecilia

The paper compares analytical methods for studying young sex chromosomes in guppies, finding that reference genome choice significantly affects results.

Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1

The paper shows SPEN and Polycomb work together in parallel for Xist-mediated gene silencing, and SmcHD1 recruitment is needed for silencing X-linked genes during differentiation.

FindZX: an automated pipeline for detecting and visualising sex chromosomes using whole-genome sequencing data

FindZX detects and visualizes sex chromosomes using whole-genome sequencing data across diverse species and taxonomic groups.

Early dosage compensation of zygotically-expressed genes in Drosophila melanogaster is mediated through a post-transcriptional regulatory mechanism

The paper investigates early dosage compensation in Drosophila melanogaster and finds that it occurs through a post-transcriptional mechanism rather than transcriptional regulation.

Developmental dynamics of sex reprogramming by high incubation temperatures in a dragon lizard

The paper investigates how high incubation temperatures reprogram sex in dragon lizards, finding that genetic factors outweigh temperature effects in determining gonadal development.

An ancient truncated duplication of the anti-Mullerian hormone receptor type 2 gene is a potential conserved master sex determinant in the Pangasiidae catfish family

The paper identifies a truncated duplication of the amhr2 gene on the Y chromosome in Pangasiid catfishes as a conserved master sex-determining gene.

Identification of sex chromosomes using genomic and cytogenetic methods in a range-expanding spider, Argiope bruennichi (Araneae: Araneidae)

The paper identifies sex chromosomes in the spider Argiope bruennichi using cytogenetic and genomic methods and develops RT-qPCR sex markers.

Inducible degradation of dosage compensation protein DPY-27 facilitates isolation of Caenorhabditis elegans males for molecular and biochemical analyses

This paper describes a method to isolate C. elegans males by degrading DPY-27, enabling molecular and biochemical analyses of male-specific processes.

Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

The paper investigates the relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in gene regulation in liver and adipose tissues using the FCG mouse model.

Allele-resolved single-cell multi-omics uncovers the dynamics and transcriptional kinetics of X-chromosome upregulation

This study uses allele-resolved single-cell multi-omics to reveal the dynamics and transcriptional kinetics of X-chromosome upregulation in mouse development.

Small silencing RNAs expressed from W-linked retrocopies of Masculinizer target the male-determining gene PxyMasc during female sex determination in the Diamondback moth Plutella xylostella

The paper identifies small silencing RNAs targeting PxyMasc, a male-determining gene in diamondback moth, expressed from W-linked retrocopies on the female-specific chromosome.

Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary

This study shows that Lhx2 in germ cells suppresses endothelial cell migration in developing ovaries, leading to increased angiogenesis.

Nucleoporin107 mediates female sexual differentiation via Dsx

The paper identifies Nup107 as a mediator of female sexual differentiation through its regulation of Dsx and BMP signaling in Drosophila.

Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals

The paper identifies early sex-specific gene expression patterns in mouse and human embryos before gonad formation, revealing conserved functions despite divergent gene orthologs.

Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in males

This paper visualizes dosage compensation in Bombyx mori males by showing both Z chromosomes are partially repressed, supporting convergent evolution with C. elegans.

A chromosome-level genome assembly enables the identification of the follicle stimulating hormone receptor as the master sex determining gene in Solea senegalensis

The paper presents a chromosome-level genome assembly for Senegalese sole, identifies the follicle stimulating hormone receptor (fshr) as the master sex determining gene, and shows its differential expression and allelic variation between sexes.

Estrogen suppresses DMRT1 expression during ovarian development in the chicken

The paper shows estrogen reduces DMRT1 protein levels in female chicken gonads during ovarian development, suggesting estrogen signaling regulates primary sex determination.

A study of thermally-induced sex reversal in casque-headed lizards

This study investigates thermally-induced sex reversal in casque-headed lizards by analyzing genotypic, histological, and transcriptomic data from embryos incubated at different temperatures.

Occasional paternal inheritance of the germline-restricted chromosome in songbirds

The paper shows that the germline-restricted chromosome (GRC) in zebra finches can be paternally inherited, challenging previous assumptions of strict maternal transmission.

Unique structure and positive selection promote the rapid divergence of Drosophila Y chromosomes

The paper studies Y chromosome evolution in Drosophila species, finding rapid divergence, new gene families under positive selection, and biased repair mechanisms.

A non-functional copy of the salmonid sex determining gene (sdY) is responsible for the "apparent" XY females in Chinook salmon, Oncorhynchus tshawytscha.

The study identifies a non-functional sdY gene variant in XY Chinook salmon females that disrupts testicular differentiation by impairing estrogen synthesis.

Functional analysis of Mmd2 and related PAQR genes during sex determination in mice

The paper investigates the role of Mmd2 and related PAQR genes in mouse sex determination, finding no essential function despite their expression in testis development.

Diversity of reptile sex chromosome evolution revealed by cytogenetic and linked-read sequencing

This study identifies candidate sex-determining genes and examines dosage compensation mechanisms in reptiles using cytogenetic and linked-read sequencing.

Evolution of the canonical sex chromosomes of the guppy and its relatives

This paper reviews and reanalyzes data on the evolution of sex chromosomes in guppies and their relatives, finding no nonrecombining sex determining region or evolutionary strata in P. reticulata.

Generation and mutational analysis of a transgenic mouse model of human SRY

The paper generates a transgenic mouse model expressing human SRY to study its role in sex determination and DSD, identifying functional domains and mutations.

seGMM: a new tool to infer sex from massively parallel sequencing data

seGMM infers sex from sequencing data with >99% accuracy, outperforming existing tools by incorporating Y chromosome features.

Prediction of the sex-determination gene in tunas (Thunnus fishes)

The paper identifies a candidate sex-determination gene in tunas by comparing male and female genomes and analyzing gene expression patterns.