C. Lu

An atlas of human viruses provides new insights into diversity and tissue tropism of human viruses

The paper curates an atlas of human viruses, revealing increased diversity in infants and factors influencing tissue tropism, while introducing the Human Virus Database.

Pparg drives luminal differentiation and luminal tumor formation in the urothelium

This study shows that Pparg promotes luminal differentiation and tumor formation in urothelial cells, with tumors showing immune desertion and potential subtype shifts over time.

Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

The paper reports monoclonal antibodies against Plasmodium berghei HAP2 and their crystal structures, showing how they block malaria transmission.

Serine Starvation Silences Estrogen Receptor Signaling through Histone Hypoacetylation

The paper shows serine starvation reduces ER expression and histone acetylation in breast cancer cells, linking metabolic stress to chromatin changes and ER pathway inactivation.

ITRAQ-based quantitative proteomic analysis of japonica rice seedling during cold stress

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

Tumor PD-L1 selectively suppresses type I interferon in myeloid cells to suppress CTL recruitment to promote lung metastasis

Epigenomic and transcriptomic differences between low-grade and acute inflammation in LPS-induced murine immune cells

This study compares epigenomic and transcriptomic changes in murine monocytes under low-grade and acute inflammation induced by LPS, identifying pathway-specific responses and epigenetic regulation differences.

Effects of hydroelectric dam construction on spatio-temporal changes of land use land cover in Bui National Park, Ghana

This study analyzes spatio-temporal changes in land use and land cover in Bui National Park, Ghana, following hydroelectric dam construction, finding significant increases in built-up areas and water bodies and decreases in forest cover.

Impact of Meteorological factors on wheat growth period and irrigation water requirement --A case study of the Beijing-Tianjin-Hebei region in China

This study examines how meteorological factors affect wheat irrigation water requirements in the Beijing-Tianjin-Hebei region from 2000 to 2019, showing trends and correlations with climate variables.

AlphaTracker: A Multi-Animal Tracking and Behavioral Analysis Tool

AlphaTracker is a computer vision tool for multi-animal tracking and behavioral analysis, designed for ease of use and real-time performance in studying social interactions in mice.

HOCMO: A Tensor-based Higher-Order Correlation Model to Deconvolute Epigenetic Microenvironment in Breast Cancer

HOCMO is a tensor-based model that deconvolutes epigenetic microenvironment signals in breast cancer using proteomics data to reveal regulatory dynamics and functional modules.

Target lipidomics reveals associations between serum sphingolipids and insulin sensitivity by the glucose clamp

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

The Himalayan Uplift and the Evolution of Aquatic Biodiversity Across Asia: Snowtrout (Cyprininae: Schizothorax) as a Test Case

This paper tests the hypothesis that Himalayan uplift dispersed aquatic biodiversity by analyzing the phylogeography of Snowtrout fish across Asia.

A single-cell RNAseq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding

This study uses single-cell RNAseq to analyze adult Schistosoma mansoni parasites, identifying a key regulator of blood feeding and gut maintenance.

Membrane-type 1 matrix metalloproteinase (MMP-14) modulates tissue homeostasis by a non-proteolytic mechanism

This study shows that MT1-MMP regulates tissue homeostasis via a non-proteolytic mechanism by controlling skeletal stem cell differentiation, independent of its proteolytic activity.

CRISPR/Cpf1 mediated genome editing enhances Bombyx mori resistance to BmNPV

This study compares CRISPR/Cpf1 orthologs for genome editing efficiency and antiviral ability in silkworms, finding FnCpf1 more effective than SpCas9 against BmNPV.

bHLH11 inhibits bHLH IVc proteins by recruiting the TOPLESS/TOPLESS-RELATED corepressors in Arabidopsis

The paper identifies bHLH11 as a negative regulator of Fe homeostasis in Arabidopsis, showing it inhibits bHLH IVc transcription factors by recruiting TOPLESS/TOPLESS-RELATED corepressors.

FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT) interacts with OsIRO2 to regulate iron homeostasis

OsFIT interacts with OsIRO2 to enhance its nuclear accumulation and activate Fe-uptake gene expression in rice.

Osmotic stress-induced, rapid clustering of IGF2BP proteins nucleates stress granule assembly

The paper shows IGF2BP proteins rapidly cluster under osmotic stress, initiating stress granule formation before other proteins, and identifies the molecular mechanisms involved.

PulseDIA: in-depth data independent acquisition mass spectrometry using enhanced gas phase fractionation

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.

VHL Synthetic Lethality Signatures Uncovered by Genotype-specific CRISPR-Cas9 Screens

The paper uses CRISPR-Cas9 screens in isogenic ccRCC cell lines to identify synthetic lethal partners of VHL, revealing new therapeutic targets for renal cell carcinoma.

Design and assessment of TRAP-CSP fusion antigens as effective malaria vaccines

This study designs and evaluates TRAP-CSP fusion antigens as malaria vaccines, finding that those containing the CSP repeat region provide complete sterile protection in mice.

CRISPR-Cas9 screening of KSHV-transformed cells identifies XPO1 as a vulnerable target of cancer cells

This study identifies XPO1 as a vulnerable target in cancer cells using CRISPR-Cas9 screening in KSHV-transformed cells, showing its role in cell proliferation and growth transformation.

LRRC33 is a novel binding and regulating protein of TGF-β1 function in human acute myeloid leukemia cells

This study identifies LRRC33 as a novel TGF-β1 binding and regulating protein in AML cells, showing its correlation with TGF-β1 expression and its role in TGF-β1 activation.

Homologous Recombination as an Evolutionary Force in African Swine Fever Viruses

This study analyzes ASFV genomes to show that homologous recombination contributes to genetic diversity through indels, with conserved enzymes involved in recombination.

Construction and Characterization of a Synthetic Baculovirus-inducible 39K Promoter

This paper constructs a synthetic inducible promoter by analyzing the 39K promoter of BmNPV and identifies key regulatory regions for virus-inducible activity.

Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis

This study shows that PLEKHO1 in osteoblasts worsens joint inflammation in RA and promotes bone formation, suggesting it as a therapeutic target.

Autophagy determines osimertinib resistance through regulation of stem cell-like properties in EGFR-mutant lung cancer

This study shows autophagy promotes osimertinib resistance in EGFR-mutant lung cancer by enhancing stem-cell like properties, and inhibiting autophagy reverses resistance.

Fusion surface structure, function, and dynamics of gamete fusogen HAP2

This study characterizes the structure, function, and dynamics of the gamete fusogen HAP2, revealing dynamic regions and structural features critical for fusion.

Repurposing cytarabine for treating primary effusion lymphoma by targeting KSHV latent and lytic replications

This study identifies cytarabine as a potent inhibitor of KSHV-induced primary effusion lymphoma by targeting both viral and host DNA/RNA synthesis and inducing tumor regression in a xenograft model.