M. Lee

High-fidelity optical diffraction tomography of live organisms using non-toxic tunable refractive index media

This paper introduces a method for high-fidelity optical diffraction tomography using non-toxic RI matching media to improve 3D refractive index reconstruction of live organisms.

In Silico Improvement of Highly Protective Anti-Malarial Antibodies

The paper improves an anti-malarial antibody using an in silico pipeline, resulting in a variant with higher binding affinity and better malaria protection.

Barcoding genetically distinct Plasmodium falciparum strains for comparative assessment of fitness and antimalarial drug resistance

This paper introduces a method to assess fitness and drug resistance in Plasmodium falciparum strains using CRISPR/Cas9 and barcode sequencing, demonstrating its ability to detect artemisinin resistance in mixed parasite populations.

Production of novel biosurfactant by a new yeast species isolated from Prunus mume Sieb. et Zucc.

This paper isolates a novel yeast strain JAF-11 capable of producing a new biosurfactant with unique chemical properties and potential industrial applications.

Central role of Prominin-1 in lipid rafts during liver regeneration

This study shows PROM1 is crucial in lipid rafts for liver regeneration by recruiting GP130 and activating the IL6-GP130-STAT3 pathway.

RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma

This study identifies RET activation driven by MAB21L4-CacyBP interaction as a driver of squamous cell carcinoma and shows RET inhibition as a potential therapeutic strategy.

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant

This study evaluates the neutralizing activity of mRNA vaccines against the SARS-CoV-2 Omicron variant, showing reduced efficacy after the second dose but improved responses following a third dose.

Dehalobium species implicated in 2,3,7,8-tetrachloro-p-dioxin dechlorination in the contaminated sediments of Sydney Harbour Estuary

This study identifies Dehalobium species in Sydney Harbour Estuary sediments capable of dechlorinating 2,3,7,8-tetrachlorodibenzo-p-dioxin, showing their role in reducing PCDD/F toxicity in marine environments.

The SPEECHLESS-induced stomatal increase is required for the salt tolerance of oil palm

This study investigates how salt stress affects oil palm by analyzing gene expression and stomatal development, finding that EgSPCH promotes stomatal increase which aids in salt tolerance.

The novel conserved NAD+ binding micropeptide SGHRT regulates mitochondrial function and metabolism in human cardiomyocytes

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

This study investigates the effect of 11β-HSD1 inhibition on tumour growth and angiogenesis in murine models, finding increased SCC tumour growth but no effect on angiogenesis.

Probing DNA-protein interactions using single-molecule diffusivity contrast

The paper introduces a method to determine DNA-protein binding states using diffusivity contrast and validates it with PIFE, enabling simultaneous mapping of stoichiometry and binding location.

Label-free three-dimensional analyses of live cells with deep-learning-based segmentation exploiting refractive index distributions

The paper develops a label-free 3D segmentation method using deep learning to analyze live cells and their organelles without exogenous labels.

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

This paper identifies a novel class of TMPRSS2 inhibitors that effectively block SARS-CoV-2 and MERS-CoV entry and show promise as a therapeutic for COVID-19.

Visualizing cancer-originated acetate uptake through MCT1 in reactive astrocytes demarcates tumor border and extends survival in glioblastoma patients

This study uses AcePET to visualize tumor boundaries and reactive astrocytes in GBM, showing that targeting MCT1 improves survival by enabling complete resection of cancer stem cells.

CCL28 modulates neutrophil responses during infection with mucosal pathogens

This study shows CCL28 enhances neutrophil responses in mucosal infections, improving pathogen clearance in some cases but worsening disease in others.

Multiple Sites on SARS-CoV-2 Spike Protein are Susceptible to Proteolysis by Cathepsins B, K, L, S, and V

This study identifies multiple SARS-CoV-2 spike protein sites susceptible to cleavage by cathepsins B, K, L, S, and V using computational and experimental methods.

Expansion Sequencing: Spatially Precise In Situ Transcriptomics in Intact Biological Systems

ExSeq enables multiplexed RNA mapping at nanoscale resolution by expanding biological specimens for in situ sequencing.

Analysis of HIV Reservoirs in Cellular Conjugates from Peripheral Blood

The paper analyzes HIV nucleic acids in cellular conjugates from peripheral blood to understand HIV reservoirs and their characteristics in different patient groups.

STING suppresses cancer pain via immune and neuronal modulation

This study shows STING agonists reduce cancer pain and bone destruction in mouse models by modulating neurons, immune cells, and osteoclasts.

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

This study characterizes the structure, conformation, and glycosylation of the SARS-CoV-2 spike protein expressed by the ChAdOx1 nCoV-19/AZD1222 vaccine, confirming its native-like properties.

Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

In vitro selection of a microbial consortium predictive of synergistic functioning along multiple ecosystem scales

The paper assesses how different microbial consortia affect phosphorus solubilization and plant growth, finding that combined species outperform individual species.

Human reference gut microbiome comprising 5,414 prokaryotic species, including newly assembled genomes from under-represented Asian metagenomes

The paper expands the human gut microbiome reference database by incorporating newly assembled genomes from under-represented Asian populations, improving taxonomic and functional classification and revealing associations with autoimmunity.

Studies on Forecasting of Incidence of Leaf Mold in Tomato and Fungicide-spray Scheduling

This study investigates leaf mold incidence in tomato under varying temperature and leaf wet duration, and evaluates fungicide efficacy over time.

Data-driven multiplexed microtomography of endogenous subcellular dynamics

This paper introduces a data-driven method for multiplexed microtomography using refractive index imaging to study endogenous subcellular dynamics without exogenous labels.

A novel, dichloromethane-fermenting bacterium in the Peptococcaceae family, 'Candidatus Formamonas warabiya', gen. nov. sp. nov.

The paper describes a novel bacterium capable of fermenting dichloromethane to acetate, providing insights into anaerobic DCM degradation and its metabolic pathways.

Dynamic multi-OMICs of glioblastoma reveal sensitivity to neddylation inhibition dependent on nuclear PTEN and DNA replication pathways

The paper investigates the dynamic multi-OMICs of glioblastoma and identifies sensitivity to neddylation inhibition, though the manuscript was withdrawn due to un reproducible findings.

Multiscale label-free volumetric holographic histopathology of thick-tissue slides with subcellular resolution

This paper introduces a label-free volumetric imaging technique for thick-tissue slides with subcellular resolution, demonstrating its ability to visualize various tumor types and pathologies.

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.