M. Li

Fast and universal single molecule localization using multi-dimensional point spread functions

This paper introduces a GPU-based B-spline PSF modeling method for fast and accurate high-dimensional single molecule analysis.

Multiple origins of dorsal ecdysial sutures in trilobites and their relatives

The paper examines the evolution of dorsal ecdysial sutures in trilobites and their relatives, finding that their origin is ambiguous and may be either ancestral or convergent.

Requirement of microtubules for secretion of a micronemal protein CpTSP4 in the invasive stage of the apicomplexan Cryptosporidium parvum

This study identifies CpTSP4, a new micronemal protein in Cryptosporidium parvum, showing its secretion during invasion and dependence on microtubular trafficking and heparin-binding for host interaction.

Pre-clinical Evaluation of Biomarkers for Early Detection of Nephrotoxicity Following Alpha-particle Radioligand Therapy

This study evaluates urinary NGAL as a non-invasive biomarker for early detection of tubular damage and long-term nephrotoxicity from alpha-particle radioligand therapy in mice.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.

Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

Rapid Development of a Mucosal Nanoparticle Flu Vaccine by Genetic Engineering of Bacteriophage T4 using CRISPR-Cas

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

Von Willebrand Factor Synergizes with Tumor-Derived Extracellular Vesicles to Promote Gastric Cancer Metastasis

This study shows that von Willebrand factor (VWF) and gastric cancer-derived extracellular vesicles (gcEVs) work together to promote metastasis by disrupting endothelial integrity and facilitating cancer cell migration.

Glioblastoma-infiltrating CD8+ T cells are predominantly a clonally expanded GZMK+ effector population

The paper analyzes TILs in GBM using CITE-seq and scRNA-seq to show that CD8+ T cells are predominantly clonally expanded GZMK+ effector cells, lacking canonical exhaustion.

Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

This study identifies lymphatic muscle cells as the pacemaker cells in mouse collecting lymphatic vessels through combined immunofluorescence, scRNA-seq, and electrophysiological analyses.

Diversity of Bathyarchaeia viruses in metagenomes and virus-encoded CRISPR system components

The paper identifies 56 metagenome-assembled genomes of Bathyarchaeia viruses and describes their CRISPR system components, revealing potential counter-defense mechanisms.

Promotion of tumor angiogenesis and growth induced by low-dose antineoplastic agents via bone-marrow-derived cells

This study investigates low-dose antineoplastic agents' effects on tumor growth and angiogenesis via bone-marrow-derived cells in mouse models.

Cooperation between bacteriocytes and endosymbionts drives function and development of symbiotic cells in mussel holobionts

The paper constructs a single-cell expression atlas of gill tissue in deep-sea mussels to study the molecular function and developmental trajectory of bacteriocytes and their interaction with endosymbionts.

Co-Occurrence Network Analysis Reveals The Alterations Of The Skin Microbiome And Metabolome In Atopic Dermatitis Patients

This study analyzes the skin microbiome and metabolome in healthy and atopic dermatitis patients to identify microbial and metabolic changes associated with the disease.

High-throughput generic single-entity sequencing using droplet microfluidics

This paper introduces GSE-Seq, a high-throughput platform for single-entity sequencing that enables long-read profiling of dsDNA and ssDNA from viruses and bacteria, revealing previously overlooked dark matter and phage-host interactions.

Wiskott-Aldrich Syndrome Protein Regulates Nucleolar Organization and Function in Innate Immune Response

This study shows that WASP regulates nucleolar structure and function, affecting rRNA transcription and inflammatory cytokine response in macrophages.

Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection.

This study shows that different growth media affect SARS-CoV-2 susceptibility in human nasal epithelial cultures but not Influenza A, with protease expression playing a role.

Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea

The paper identifies a novel UEV-Vps23 family protein in Asgard archaea that mediates an ancient ESCRT-ubiquitin interplay, suggesting this pathway predates eukaryotic endomembrane systems.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration

This study shows that macrophage-specific Xanthine Oxidoreductase (XOR) exacerbates LPS-induced lung injury by promoting NLRP3 inflammasome expression and glycolytic metabolism in inflammatory macrophages.

AMPK targets PDZD8 to trigger carbon source shift to glutamine

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

Extended lifespan in female Drosophila melanogaster through late-life caloric restriction.

This study shows that late-life caloric restriction extends lifespan in female Drosophila melanogaster by reducing mortality and altering reproductive energy allocation.

BNIP3-mediated mitophagy boosts the competitive dominant growth of lenvatinib resistant cells via reprogramming energy metabolism in HCC

This study identifies BNIP3-mediated mitophagy as a mechanism enhancing lenvatinib-resistant HCC cells' competitive growth through energy metabolism reprogramming.

Detection and editing of the updated plastid- and mitochondrial-encoded proteomes for Arabidopsis with PeptideAtlas

This study identifies and analyzes RNA editing sites in plastid and mitochondrial proteomes of Arabidopsis using mass spectrometry data from PeptideAtlas.

CLIPB4 is a central node in the protease network that regulates humoral immunity in Anopheles gambiae mosquitoes

The paper identifies CLIPB4 as a central protease in the immune network of Anopheles gambiae, showing its role in melanization and antibacterial immunity through interactions with SRPN2.

The complex roles of genomic DNA modifications of bacteriophage T4 in resistance to nuclease-based defense systems of E. coli

The paper investigates how genomic modifications in phage T4 DNA affect its resistance to nuclease-based defense systems in E. coli, revealing roles beyond simple DNA degradation prevention.

African swine fever virus I196L is a virulence determinant and its deletant induces robust protection in Domestic pig

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

Mapping the Arabidopsis thaliana proteome in PeptideAtlas and the nature of the unobserved (dark) proteome; strategies towards a complete proteome

This paper updates the Arabidopsis thaliana PeptideAtlas proteomics resource, identifies 78.6% of the predicted proteome, and uses a machine learning model to predict the dark proteome.