Malaria Research and Control

The impact of insecticide decay on the rate of insecticide resistance evolution for monotherapies and mixtures.

This study models how insecticide decay affects resistance evolution in monotherapies and mixtures, showing decayed insecticides can increase selection pressure and reduce the effectiveness of mixtures.

Immunological surveillance using gSG6-P1 biomarker reveals spatio-temporal dynamics of Anopheles exposure and gaps in malaria risk assessment

This study uses anti-gSG6-P1 antibody levels to assess Anopheles exposure seasonality and human behavior impacts on malaria risk in Sisaket Province.

Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies

The paper determines the structure of the Pfs230:Pfs48/45 complex bound to transmission-blocking antibodies, revealing molecular interactions and epitopes that inform vaccine development.

Targeted genomic surveillance of insecticide resistance in African malaria vectors

This paper develops a targeted genomic surveillance approach for insecticide resistance in malaria vectors, identifying resistance variants and demonstrating predictive modeling with high accuracy.

Late killing of Plasmodium berghei in the liver by an anti-circumsporozoite protein monoclonal antibody

The paper shows that the 3D11 anti-CSP monoclonal antibody neutralizes Plasmodium berghei sporozoites in the liver after several hours, inhibiting motility and leading to parasite killing.

Distinguishing new from persistent infections at the strain level using longitudinal genotyping data

The paper develops DINEMITES, a statistical method to distinguish new from persistent infections using longitudinal genotyping data, showing improved accuracy over simple rules.

DNA replication dynamics are associated with genome composition in Plasmodium species

This study compares DNA replication dynamics in two Plasmodium species with different A/T-content genomes, finding that P. falciparum has slower and more consistent replication fork speeds despite high A/T bias.

A protocol for a systematic review and individual patient data meta-analysis investigating the relationship between Pfkelch13 mutations and response to artemisinin-based treatment for uncomplicated falciparum malaria.

A paradoxical population structure of var DBLα types in Africa

The paper examines the population structure of DBLα types in Sub-Saharan Africa, finding varying conservation levels across geographical scales and frequencies.

Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity

This study identifies quinoxaline-based anti-schistosomal compounds with potent anti-malarial activity against Plasmodium falciparum, including resistance mechanisms involving pfqrp1 and pfatp2.

Virus-like particle-based vaccines targeting the Anopheles mosquito salivary protein, TRIO

This study develops a TRIO VLP vaccine targeting Anopheles mosquito salivary protein to enhance immunity against Plasmodium, showing strong antibody responses but limited protective efficacy in a malaria challenge model.

Anopheles stephensi larval habitat superproductivity and its relevance for larval source management in Africa

The paper investigates Anopheles stephensi larval habitat productivity in Ethiopia, finding that superproductive sites dominate larval populations during dry seasons, suggesting targeted control could reduce their numbers.

Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei

This paper develops a new Plasmodium berghei parasite line with constitutive Cas9 and inducible Cre recombinase for conditional gene editing, demonstrating its use in knocking out the CLAMP gene.

Modeling the Impact of Seasonality on Mosquito Population Dynamics: Insights for Vector Control Strategies.

This study models how seasonal weather affects mosquito population dynamics in different regions, showing that ignoring seasonality leads to inaccurate predictions of mosquito abundance and stage structure.

Distinct Genetic Populations and Resistance Backgrounds of the Malaria Vector Anopheles funestus in Tanzania

The paper analyzes the population genetics of Anopheles funestus in Tanzania, identifying two distinct genetic populations with different resistance backgrounds and suggesting geographic barriers to gene flow.

Delayed copulation and mating in the malaria vector Anopheles funestus compared to Anopheles arabiensis

This study compares mating behavior between Anopheles funestus and Anopheles arabiensis under controlled conditions, finding species-specific differences in copulation timing and light response.

A systematic targeted genetic screen identifies proteins involved in cytoadherence of the malaria parasite P. falciparum.

The paper identifies proteins involved in cytoadherence of P. falciparum by genetically modifying 15 exported proteins and showing aberrant adhesion in three modified lines.

The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole

This study identifies PP1 phosphatase as a dual regulator of the malaria parasite's egress pathway, controlling cGMP homeostasis and vacuole rounding-up.

Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype

The paper identifies novel PfEMP1 variants associated with rosetting in Plasmodium falciparum, expanding the known types of PfEMP1 that mediate this phenotype.

Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion

This study identifies Casein Kinase 2 as the kinase responsible for phosphorylating VAR2CSA, enhancing its CSA binding and infected erythrocyte adhesion.

PHYSICAL EXERCISE RESTORES NEUROCOGNITIVE HOMEOSTASIS DISRUPTED BY NON-SEVERE MURINE MALARIA

Clonality, specificity, and HLA restriction of human T cell receptors against Plasmodium falciparum CSP

This study identifies conserved CD4+ T cell epitopes in PfCSP and shows their HLA-independent presentation, suggesting potential for strain-transcending malaria vaccines.

Understanding the biochemical significance of the mitochondrial pyruvate carrier in the rodent malarial parasite, Plasmodium berghei

This study identifies the mitochondrial pyruvate carrier in Plasmodium berghei as non-essential for blood stages and ookinete formation, revealing an alternative metabolic pathway for acetyl-CoA production.

Higher multiplication rates of Plasmodium falciparum in isolates from hospital cases compared with community infections

This study compares Plasmodium falciparum multiplication rates between hospital and community infections, finding higher rates in hospital isolates and a positive correlation with parasitaemia.

Machine Learning Reveals Immediate Disruption in Mosquito Flight when exposed to Olyset Nets

This study uses machine learning to analyze mosquito flight behavior around insecticide-treated nets, finding immediate disruption in flight patterns regardless of insecticide resistance.

Biochemical Characterization and Inhibitor Discovery for PfSir2A -- New Tricks for An Old Enzyme

This study characterizes PfSir2A's biochemical properties and identifies inhibitors, revealing its nucleosome and fatty acid regulation and discovering small molecule inhibitors for antimalarial development.

Ultrastructural expansion microscopy (U-ExM) visualization of malaria parasite dense granules using RESA as a representative marker protein

This study uses ultrastructural expansion microscopy to visualize RESA in malaria parasite dense granules, confirming its localization and facilitating the identification of novel DG proteins.

Regular Plasmodium falciparum importation onto Bioko Island, Equatorial Guinea, hampers malaria elimination from the island

This study uses genomic data to show that imported Plasmodium falciparum infections from Gabon are contributing to malaria transmission on Bioko Island, highlighting the need for regional control efforts.

Comparing newly developed SNP barcode panels with microsatellites to explore population genetics of malaria parasites in the Peruvian Amazon

The paper compares SNP barcode panels with microsatellites to assess population genetics of malaria parasites in the Peruvian Amazon, finding comparable results between the methods.

The Plasmodium falciparum NCR1 membrane protein is a novel antimalarial target that exports cholesterol to maintain membrane homeostasis

This paper presents three structures of PfNCR1, a Plasmodium falciparum membrane protein, and shows it exports cholesterol to maintain membrane homeostasis, with MMV009108 inhibiting this function.