Lipid Membrane Structure and Behavior

Cholesterol-Dependent Structure and Dynamics of Curved Lipid Vesicles Revealed by Dry MARTINI Simulations

This study uses Dry MARTINI simulations to investigate how cholesterol affects the structure and dynamics of curved lipid vesicles, finding increased membrane thickness and altered lipid behavior with higher cholesterol concentrations.

Design of Fluorescent Membrane Scaffold Proteins for Nanodiscs

The paper develops fluorescent membrane scaffold proteins for nanodiscs, enabling applications like monitoring membrane protein interactions through fluorescence resonance energy transfer.

Cholesterol differentially regulates α-synuclein binding across membrane packing regimes

This study shows cholesterol's effect on α-synuclein binding depends on membrane packing state, with cholesterol reducing, enhancing, or having little effect based on lipid composition and curvature.

Exogenous antimicrobial straight-chain unsaturated fatty acids promote low-temperature growth of Staphylococcus aureus

This study shows that exogenous antimicrobial straight-chain unsaturated fatty acids (SCUFAs) promote low-temperature growth of Staphylococcus aureus by altering membrane lipid composition and enhancing carotenoid production.

Size-dependent membrane remodelling at Myomerger clusters during myoblast fusion

This study investigates how Myomerger clusters of different sizes influence membrane remodeling during myoblast fusion, showing size-dependent effects on membrane tension and lipid compaction.

Spatial deconstruction of the plasma membrane

This study uses fluorescence microscopy and compositional analysis to show that plasma membrane proteins and lipids segregate into protein-rich domains and protein-poor regions, suggesting functional segregation of membrane processes.

Coupling between sterol and sphingolipid structure in ordered membrane domains

This paper investigates how sterol structure and sphingolipid chain length influence membrane order and phase behavior in yeast vacuole membranes.

Identification of lipid specificity in membrane organizing protein complexes

The paper identifies lipid specificity in membrane organizing protein complexes by mapping lipid-protein interactions and demonstrating phosphatidylethanolamine's role in stabilizing NDC1 and MIC60.

A minimal kinase-phosphatase system and its lipid substrates self-organize into dynamic patterns

The paper reports an in vitro system of lipid kinases and phosphatases that self-organize into dynamic spatiotemporal patterns on model membranes.

Cholesteryl Esters Modulate Lipid Droplet Rigidity and Monolayer Organization during Liver Cancer Progression

This study uses molecular dynamics simulations to show that cholesteryl esters increase lipid droplet rigidity and monolayer organization in liver cancer.

Lipid Headgroup Hydration Regulates Distinct Remodeling of the Membrane Interface by Polyethylene Glycol and Dextran

This study shows that lipid headgroup hydration, not charge, determines how neutral polymers like PEG and DEX interact with model membranes, leading to distinct structural changes.

Dynamic diffusion analysis of the yeast plasma membrane using Airyscan based microscopic techniques

This study compares FCS and FRAP techniques to measure diffusion in yeast plasma membrane proteins, revealing discrepancies in Sso2 diffusion due to subdomain localization.

Influence of Lipomannan and Lipoarabinomannan Concentration on Mycobacterial Inner Membranes Characterized by All-atom Simulations

This study uses all-atom simulations to examine how varying concentrations of lipomannan and lipoarabinomannan affect the structure and dynamics of mycobacterial inner membranes.

Interplay Between Cholesterol Concentration and Membrane Curvature in Liposomes Revealed by Molecular Dynamics Simulations

This study uses molecular dynamics simulations to show how cholesterol concentration and membrane curvature affect the structure and dynamics of liposomes composed of DOPC and cholesterol.

Excited state Relaxation Activation Energy (ESRAct) of Di-4-ANEPPDHQ Maps Nanoscale Molecular Organization in Biomembranes

The paper introduces ESRAct, a method using Di-4 fluorescence lifetime to quantify membrane phase states, showing it correlates with nanoscale disorder in lipid phases.

Multi-body Fluctuation-Induced Forces Between Membrane Proteins: Insights from Mesoscale Simulations

This study shows that membrane fluctuations can drive protein clustering and organization without direct interactions, using mesoscale simulations to demonstrate the role of membrane rigidification and curvature.

FLiPA: A versatile platform for quantitative analysis of protein-glycosphingolipid interactions

FLiPA quantitatively analyzes protein-glycosphingolipid interactions using fluorescent liposomes to study molecular determinants like cholesterol and membrane order.

From biting to engulfment: Target mechanics determines modes of phagocytosis through curvature--actin coupling

This paper develops a theoretical model to simulate phagocytosis of deformable targets and identifies three mechanical regimes based on target stiffness, validated experimentally with GUVs and lymphoma cells.

Simulations show increased lipid interdigitation in transmembrane coupling of protein condensates

The paper uses simulations to show that increased lipid interdigitation mediates transbilayer coupling of protein condensates by reducing lipid entropy and altering membrane curvature.

Myelin Basic Protein Binding Is Modulated by Leaflet Asymmetry and Lipid Composition

This study shows that Myelin Basic Protein binding to myelin membranes is influenced by lipid asymmetry and composition, with asymmetric membranes showing stronger binding than symmetric or disease-modified ones.

Molecular models for Gram-positive bacterial strains: Assessing membrane properties and small molecule interactions for S.aureus, S. epidermidis and N. lacusekhoensis

This study compares membrane properties and small molecule interactions in three Gram-positive bacteria, finding conserved membrane characteristics despite compositional differences.

Membrane Thickness Strain from Protein Inclusions: A Multiscale Simulation and X-Ray Scattering Study of Proteoliposomes

This study uses multiscale simulations and X-ray scattering to quantify membrane strain caused by protein inclusions in proteoliposomes, showing agreement between simulations and experiments.

SARS-CoV-2 membrane protein conformations induce distinct membrane curvatures

This study shows SARS-CoV-2 M protein conformations induce distinct membrane curvatures, matching virion regions and enabling spatial segregation through curvature-mediated interactions.

SAS_MoCa: a software for small-angle scattering data analysis of large unilamellar vesicles

SAS_MoCa is an open-source Python package for analyzing small-angle scattering data from large unilamellar vesicles, providing posterior parameter distributions and uncertainties using a Bayesian framework.

The Hidden Cost of Fusion: Intrinsic Asymmetry in Vesicle Fusion Restricts Synthetic Cell Growth

The paper shows that rapid vesicle fusion in synthetic cells causes lipid asymmetry, leading to curvature, tension, and instability, highlighting the mechanical costs of fusion.

Two-Step Mechanism of Bruton's Tyrosine Kinase MembraneRecruitment and Activation

This paper uses native mass spectrometry to show BTK recruits to membranes via phosphatidylserine and is activated by PIP3, proposing a two-step mechanism for membrane recruitment and activation.

Membrane Environment Sets the Functional pKa of Ionizable Lipids

This study uses molecular dynamics simulations to show that membrane composition significantly affects the pKa of aminolipids in lipid nanoparticles, influencing their pH-dependent behavior and membrane remodeling.

Mammalian MemPrep establishes the lipid composition of ER membranes in HEK293T cells

This study characterizes the lipid composition of mammalian ER membranes using MemPrep, showing a common lipid profile across ER subdomains and linking lipid and protein biophysical properties.

Charge and steric hindrance in the glycocalyx govern membrane interactions

This study shows how the glycocalyx regulates liposome interactions with membranes through charge and steric effects, enabling fusion and internalization.

Spatial Organization of Lipids Drives GPCR Conformational Equilibria

The paper investigates how lipid organization in nanodiscs affects GPCR conformational states, finding that anionic lipid concentration thresholds vary between POPS and POPG.