Ovarian cancer diagnosis and treatment

A Collagen-Based 3D Microtissue Platform Preserves Structural, Molecular, and Therapeutic Heterogeneity in Ovarian Cancer

This paper develops a collagen-based 3D microtissue model of ovarian cancer that preserves structural, molecular, and therapeutic heterogeneity across different histotypes.

Tumour architecture shapes polarized epithelial states that predict survival in high-grade serous ovarian cancer

The paper identifies a polarization axis in ovarian cancer cells linked to tumor architecture and survival, showing SecB cells correlate with poor prognosis and metastasis.

Spatial transcriptomics reveals interferon pathway enrichment in early relapsing serous carcinoma

This study uses spatial transcriptomics to identify interferon pathway enrichment in early relapsing high-grade serous carcinoma, linking it to poor prognosis and suggesting C3 as a biomarker.

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.

Spatial transcriptomics reveals tumour cell-intrinsic and microenvironmental features associated with survival in high-grade serous ovarian carcinoma

This study uses spatial transcriptomics to identify tumour-intrinsic and microenvironmental features linked to survival in high-grade serous ovarian carcinoma.

Novel Replication Stress-Associated High-Grade Serous Ovarian Cancer Models Recapitulate Diverse Tumour Ecosystems and Enable Preclinical Studies

This study develops HGSC models with RS-associated mutations to explore diverse tumour ecosystems and therapeutic responses.

Oxaliplatin and 5-Fluorouracil induce p53-p21-pRb-associated cell cycle arrest and a transient senescence-like phenotype in patient-derived low-grade serous ovarian cancer cells

This study shows that oxaliplatin and 5-fluorouracil induce a transient senescence-like phenotype and G0/G1-phase arrest in LGSOC cells via the p53-p21-pRb pathway, without killing the cells.

ZNF217 promotes receptor tyrosine kinase plasticity and AXL-ERK dependency in ovarian cancer

This study identifies ZNF217 as a driver of chemoresistance in ovarian cancer by promoting AXL-ERK signaling plasticity and resistance to ERBB2 inhibitors.

Spatially resolved transcriptional programs link fallopian tube precursor lesions to immune activation and stromal reorganization

This study uses spatial transcriptomics to analyze fallopian tube lesions and identifies immune and stromal changes associated with early ovarian cancer development.

Identifying multi-omics biomarkers for ovarian cancer survival estimation

This paper develops a multi-omics machine learning framework to estimate ovarian cancer survival, identifying a 20-biomarker signature that improves prognostic accuracy.

Topical Activatable Fluorescence Probes for Rapid Intraoperative Detection of Peritoneal Dissemination in High-Grade Serous Ovarian Carcinoma

This paper develops three topical fluorescence probes for intraoperative detection of peritoneal dissemination in high-grade serous ovarian carcinoma, showing high sensitivity and specificity in clinical and mouse models.

Long-read, whole-genome sequencing and chemotherapy response of two patient-derived organoids from a TP53- and KRAS-mutant ovarian carcinoma

This paper describes two patient-derived organoids from a TP53- and KRAS-mutant ovarian carcinoma, showing differential chemotherapy response and using long-read sequencing to characterize structural variants and methylation differences.

Patient-Derived Organoids Functionally Stratify Epithelial Ovarian Cancer into Clinically Relevant Chemotherapy Response Phenotypes

This study uses patient-derived organoids to classify ovarian cancer into chemotherapy response phenotypes, showing they correlate with clinical outcomes and traditional biomarkers.

Aging increases ovarian cancer growth, metastasis, and immunosuppression that can be alleviated by inhibiting hedgehog signaling

This study shows aging promotes ovarian cancer growth and immunosuppression, which can be mitigated by inhibiting Hedgehog signaling in mice and correlates with immune checkpoint resistance in humans.

Single-cell transcriptomics of heterogeneous patient-derived organoids reveals novel therapeutic targets in high-grade serous ovarian cancer

This study uses single-cell transcriptomics on patient-derived organoids to identify AGRIN as a regulator of metastatic competence in high-grade serous ovarian cancer.

Spatial transcriptomic analysis reveals coordinated gene expression in ovarian clear cell carcinoma and adjacent endometriosis in UK and Japanese patients

This study uses spatial transcriptomics to compare gene expression in ovarian clear cell carcinoma and adjacent endometriosis across UK and Japanese patients, finding distinct transcriptional patterns by tissue compartment rather than geographic origin.

Blood Based Biomarkers of DNA Methylation Associated with Platinum Resistance in High Grade Serous Ovarian Cancer

On the predictability of progression-free survival in ovarian cancer from NanoString gene expression data

This study investigates the predictability of progression-free survival in ovarian cancer using NanoString gene expression data from pre- and post-chemotherapy samples, finding low predictability and suggesting the need for larger datasets.

CACNA1C as a Prognostic Biomarker and Therapeutic Target in High-Grade Serous Ovarian Cancer: Clinical Validation and Molecular Dynamics of Nifedipine Blockade

This paper identifies CACNA1C as a prognostic biomarker and therapeutic target in high-grade serous ovarian cancer, showing nifedipine suppresses tumor growth through calcium channel blockade.

Transcriptomic subtypes in high-grade serous ovarian cancer are driven by tumor cellular composition

This study shows HGSC transcriptomic subtypes are driven by tumor cellular composition rather than intrinsic biology, with high predictive accuracy using deconvolution methods.

Comprehensive drug efficacy data for mucinous ovarian carcinoma using a novel and extensive biobank of patient-derived organoid models

This paper develops a large biobank of patient-derived MOC organoids and screens them for drug efficacy, finding resistance to standard therapies and effectiveness of less commonly used drugs.

Comparative single-cell atlases reveal injury-driven tubal epithelial regeneration as a window for ovarian carcinoma initiation

The paper compares single-cell transcriptomes of mouse and human tubal epithelium to show injury-driven regeneration in humans may contribute to ovarian cancer initiation.

MRPL47 as a Novel Mitochondrial Biomarker for Early Detection and Therapeutic Response in Ovarian Cancer

This study identifies MRPL47 as a biomarker for ovarian cancer, showing its association with poor survival, metabolic changes, and therapeutic response.

Single-Cell Transcriptomic Signatures Enable Stratified Combination Therapy for Platinum-Resistant Ovarian Cancer

The paper uses single-cell RNA sequencing to identify resistance signatures in ovarian cancer and develops a framework for combination therapy with carboplatin.

Stromal estrogen signaling regulates fallopian tube homeostasis and cancer initiation via inflammatory pathways

This study shows that estrogen receptor signaling in fallopian tube stromal cells maintains epithelial homeostasis by promoting proliferation and ciliated differentiation, but excessive estrogen shifts this niche toward inflammation and stemness, contributing to cancer initiation.

Deconvolved tumor adipocyte proportions and high grade serous ovarian carcinoma survival

The paper deconvolves adipocyte proportions from bulk RNA-seq data of HGSOC tumors and finds higher adipocyte content is associated with worse survival.

Connecting mitochondrial metabolism and mitotic fidelity to control vulnerability of high grade serous ovarian cancer patients to taxane-based chemotherapy

This paper identifies syntabulin as a determinant of chemosensitivity in high-grade serous ovarian cancer by linking mitochondrial metabolism and mitotic fidelity.

Effects of a novel proteasome inhibitor, UR238 on the tumor immune microenvironment and growth in epithelial ovarian cancer

Generation of an in vitro 3D multicellular culture model of ovarian high-grade serous carcinoma

This paper describes a protocol to generate a 3D multicellular model of ovarian high-grade serous carcinoma that includes stromal cells and organoids for drug testing and scRNA-seq.

MEX3A control of mitochondrial fitness is essential for ovarian clear cell carcinoma tumorigenesis and liver metastasis

This study shows MEX3A promotes ovarian clear cell carcinoma tumorigenesis and liver metastasis by maintaining mitochondrial fitness independently of p53.