Autophagy in Disease and Therapy

Activation of the protective arm of renin-angiotensin system enhances mitochondrial turnover improving respiration and decreasing integrated stress response in a human Complex III deficiency model.

This paper shows that activating the MasR receptor with CAP-1902 improves mitochondrial function in a human Complex III deficiency model by enhancing turnover and reducing stress.

Loss of Lamp2a-dependent chaperone-mediated autophagy drives dry AMD-like retinal pathology in mice and is rescued by BK channel activation

This study shows that loss of CMA in mice leads to AMD-like retinal pathology, which is reversed by activating BK channels with GLA-1-1.

miR-378a and NPNT coordinate autophagy regulation in podocytes through mTOR and MAPK signaling

This study identifies miR-378a and NPNT as regulators of autophagy in podocytes through mTOR and MAPK signaling, revealing their roles in glomerular disease.

ULK1 drives NDP52-mediated selective autophagic degradation of MHC-I to promote immune evasion in HPV-positive head and neck cancer

This study identifies ULK1-driven autophagy as a mechanism by which HPV+ HNC cells degrade MHC-I, promoting immune evasion and tumor growth.

ULK1-linked mitophagy promotes cardiac hypoxia tolerance in the blind mole-rat

This study identifies ULK1-linked mitophagy as a mechanism enabling cardiac hypoxia tolerance in blind mole-rats through metabolic and mitochondrial adaptations.

Full length TECPR1 displays cis Dysferlin domain architecture

The paper reports the structure of full-length TECPR1 using cryo-EM, revealing its cis Dysferlin domain architecture and stabilizing intramolecular interface.

Ubiquitination-mediated mitochondrial protein degradation ensures seedling emergence by regulating ER-mitochondrial interaction and mitophagy

This study identifies SPL2 as a mitochondrial E3 ligase that regulates seedling emergence by controlling ER-mitochondrial interactions and mitophagy through ubiquitination of mitochondrial proteins.

ACTIVATED CASO₄-INDUCED VACUOLATION AS A QUANTITATIVE PLATFORM FOR PHAGOCYTOSIS-DRIVEN DRUG SCREENING

This paper introduces a method using thermally activated calcium sulfate (ACS) to induce vacuolization in mammalian cells, enabling a scalable platform for drug screening related to phagocytosis and lysosomal function.

NBR1 shuttles between the cytoplasm and nucleus and is essential for nuclear p62 body formation

Physiological cerebrospinal fluid like medium reveals autophagy dependency of leukaemia in the central nervous system

This study develops a physiological CSF-like medium to culture CNS-ALL cells, revealing autophagy as a critical survival mechanism in the CNS niche.

Oncogenic ERK signaling represses chaperone-mediated autophagy through transcriptional control of LAMP-2A

The paper identifies ERK signaling as a suppressor of chaperone-mediated autophagy (CMA) and shows that inhibiting ERK can restore CMA by increasing LAMP-2A expression.

A Phosphoinositide Interacting Protein Coordinates Stress Precursor Activities

The paper shows Samd14 maintains autophagy balance in red blood cell precursors during acute anemia by interacting with PI3P and modulating VPS34 activity.

Time-resolved functional genomics using deep learning reveals a global hierarchical control of autophagy

This study uses deep learning and time-resolved imaging to map the genetic network controlling autophagy dynamics, revealing a hierarchical control mechanism and new regulatory aspects.

Autophagy induction requires the suppression of potassium influx mediated by phosphatases

This study shows that phosphatases Ppz1 and Ppz2 suppress potassium influx via Trk1 and Trk2 to enable autophagy in yeast.

Lysosomal abundance in young and aged mouse hearts assessed by In Vivo Imaging Systems (IVIS) Lysotracker imaging and autophagy-related gene expression

The paper uses IVIS Lysotracker imaging and RT-qPCR to assess lysosomal abundance and autophagy-related gene expression in young and aged mouse hearts, finding preserved acidic-vesicle pool and stable gene expression.

Cytoplasmic mRNA granules regulate cell fate decisions during PINK1/Parkin mitophagy

The paper identifies mitophagy-induced mRNA granules (mitoRGs) that regulate cell fate during PINK1/Parkin mitophagy by controlling PGAM5 activity.

Synthesis and Characterization of ULK1/2 Kinase Inhibitors that Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer

The paper reports the design, synthesis, and characterization of new ULK1/2 inhibitors that inhibit autophagy and upregulate MHC I in NSCLC cells, supporting their potential as cancer therapeutics.

Cyclin C Promotes Pancreatic Development and Suppresses Cancer Initiation Through Maintenance of the Autophagy-Lysosome Pathway

This study shows cyclin C maintains autophagy-lysosome pathway function in pancreatic development and suppresses cancer by eliminating damaged cells, with potential therapeutic implications for pancreatic neoplasms.

Decoding ATG9A Variation: A Comprehensive Structural Investigation of All Missense Variants

This study predicts the impact of all missense variants in ATG9A using structural analysis and variant effect predictors, identifying potentially damaging variants and their molecular mechanisms.

Elevated lysosomal mass and enzyme activity in fibroblasts of the Mediterranean mouse Mus spretus

The paper compares lysosomal characteristics between fibroblasts of two mouse species, finding elevated lysosomal mass and enzyme activity in M. spretus compared to M. musculus.

Reversible One-way Lipid Transfer at ER-Autophagosome Membrane Contact Sites via Atg2

The paper uses a novel fluorescent probe to show reversible phospholipid transfer between ER and autophagosome membranes in vivo.

Endothelial Cell Autophagy Suppresses Metastasis In Mouse Mammary and Pancreatic Neuroendocrine Tumor Models

This study shows that endothelial cell autophagy reduces metastasis in mouse breast and pancreatic neuroendocrine tumor models by delaying tumor growth and increasing apoptosis.

PDZD-8 interacts with LGG-2/LC3 to promote autolysosome formation

This study identifies PDZD-8 as an ER protein that interacts with LGG-2/LC3 to promote autolysosome formation by bridging ER-autophagosome contacts.

Cyanine dye conjugates of a 2'-deoxycytidine-based auto- and mitophagy activator extend Caenorhabditis elegans lifespan

The paper identifies a 2'-deoxycytidine-based compound that activates autophagy and mitophagy, extends C. elegans lifespan when conjugated with a mitochondria-targeting dye.

Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells

This study develops capsaicin-derived ligands that modulate the AURKA/PHB2 interaction and mitophagy in cancer cells, with compound 13 showing promise as a specific inhibitor of AURKA-dependent mitophagy.

NCOA4 initiates ferritinophagy by avidly binding GATE16 using two short linear interaction motifs

This paper identifies two short linear motifs in NCOA4 that bind GATE16 with high avidity, enabling ferritinophagy and revealing a mechanism for iron-dependent regulation of this process.

Glycophagy is an ancient bilaterian pathway supporting metabolic adaptation through STBD1 structural evolution

This study identifies STBD1 as a conserved glycophagy receptor in bilaterians, showing its structural evolution supports metabolic adaptation across species.

ATG gene duplication in vertebrates: evolutionary divergence and its functional implications

This study investigates ATG gene duplication in vertebrates, showing that most ATG genes were duplicated via whole-genome events near the vertebrate root and explores functional divergence patterns among paralogs.

SQSTM1/p62 accumulation is a hallmark of FLCN loss in Birt-Hogg-Dube syndrome-associated kidney cancer

The paper shows SQSTM1/p62 accumulates in BHD kidney tumors due to FLCN loss, but is not required for tumor growth.

Mitochondrial fission during mitophagy requires both inner and outer mitofissins

This study identifies Mfi2, a mitochondrial outer membrane microprotein required for mitophagy, showing that both inner and outer mitofissins are needed for mitochondrial fission during mitophagy.