Autophagy in Disease and Therapy

HOPS is required for non-canonical mTORC1 signaling by recruiting Rags and FLCN to lysosomal membranes

This study shows that the HOPS complex recruits Rags and FLCN to lysosomal membranes, enabling non-canonical mTORC1 signaling and lysosomal biogenesis.

LAMP2A-dependent chaperone-mediated autophagy enhances oxidative stress resistance in gastric cancer cells through selective degradation of accumulated oxidized DJ-1

This study shows that LAMP2A-dependent CMA enhances oxidative stress resistance in gastric cancer by degrading oxidized DJ-1, preventing apoptosis and promoting survival.

Au_Sus: A tiered consensus census of human autophagy genes

Au_Sus provides a high-confidence human autophagy gene census through consensus of databases and literature, revealing a core 201-gene set with significant associations to neurodegeneration and oncology.

Feedback loops involving AMPK, ERK and TFEB in matrix detachment leads to non-genetic heterogeneity

The paper identifies a feedback loop between AMPK, ERK, and TFEB in matrix-detached cancer cells that generates non-genetic heterogeneity, affecting autophagy and cell survival.

TBK1 restricts IRGQ-mediated autophagy

This study identifies TBK1 as a regulator of IRGQ-mediated autophagy by disrupting the IRGQ-GABARAPL2 complex through phosphorylation of GABARAPL2.

Intracellular lipopolysaccharide binds RETREG1/FAM134B to regulate ER remodeling upon bacterial infection

This study shows that bacterial LPS binds RETREG1 to induce ER remodeling and enhance antibacterial defense through ERphagy.

A role for CASM in the repair of damaged Golgi architecture

This study shows that CASM helps repair damaged Golgi structure by coordinating with lysosomal biogenesis in TRIM46-deficient cells.

Chemical N-degrons activate p62-mediated mitophagy to alleviate mitochondrial neuropathies

This study identifies ATB1071, a compound that activates p62-mediated mitophagy through Arg/N-degrons, showing therapeutic benefits in mitochondrial neuropathies and ischemia-reperfusion injury.

Root hair lifespan is antagonistically controlled by autophagy and programmed cell death

The paper shows that autophagy extends root hair lifespan, while its loss triggers cell death via a gene network involving ANAC046 and ANAC087.

Dynamic Regulation of Atg4 Protease and Autophagy by Dithiothreitol and Iron in Alternaria alternata

This study investigates how DTT and iron modulate autophagy in Alternaria alternata by affecting AaAtg4 protease activity and AaAtg8 lipidation.

CD4+ T cell activation is dependent on a novel form of ULK1/2-independent autophagy

This study identifies a novel form of autophagy in CD4+ T cells that is independent of ULK1/2 and occurs alongside mTORC1 activation, supporting proliferation and cytokine production.

Title - ATG7 vs. ATG5: Distinct Autophagy Pathways Shaping TGF-β Signaling and Endothelial Function

This study compares the roles of ATG5 and ATG7 in modulating TGF-β signaling and endothelial function, showing distinct effects on gene expression and cellular behavior.

CANE1-mediated autophagosome size regulation fine-tunes phosphate starvation tolerance in Arabidopsis thaliana

This study identifies CANE1 as a regulator of autophagosome size in Arabidopsis thaliana under phosphate starvation, linking it to ER stress and autophagy.

ATG deficiency impairs stationary-phase microlipophagy through acetic acid-induced clustering of Niemann-Pick type C proteins

The paper shows that ATG deficiency impairs stationary-phase microlipophagy in yeast due to acetic acid-induced NPC protein clustering, which can be rescued by reducing extracellular acetic acid.

Mitophagosomes induced during EV-D68 infection promote viral nonlytic release

This study shows EV-D68 induces mitophagy to facilitate nonlytic viral release, distinct from its role in supporting viral replication.

A mycobacterial Sec61 inhibitor disrupts lysosome function by blocking Vacuolar-ATPase biosynthesis.

The paper shows that mycolactone disrupts lysosome function by inhibiting Vacuolar-ATPase biosynthesis through Sec61 inhibition, leading to proteostatic stress and impaired phagocytic response to M. ulcerans.

Lysosomal accumulation of Masitinib alters autophagy via pH-dependent trapping.

This study shows that masitinib accumulates in lysosomes via pH-dependent trapping, disrupting autophagy by impairing lysosomal acidification.

Catalase 2-dependent regulation of autophagy in response to carbon starvation in Arabidopsis

The paper investigates how catalase 2 regulates autophagy during carbon starvation in Arabidopsis by modulating redox-sensitive interactions with autophagy initiators.

Synapse specific alterations of autophagy are a hallmark of Danon disease

This study identifies synapse-specific autophagy alterations in Danon disease using a Xenopus tropicalis model, linking them to visual and cognitive impairments.

Starvation-induced autophagy occurs independently of the ATG1 complex in Chlamydomonas

This study shows that starvation-induced autophagy in Chlamydomonas occurs without the ATG1 complex, suggesting an alternative pathway for autophagy initiation.

Parkinson disease-associated protein DJ-1 regulates the autophagic-lysosomal pathway through ROS-dependent modulation of the AMPK/mTORC1 axis.

This study shows that DJ-1 deficiency impairs autophagosome-lysosome fusion and lysosomal degradation, leading to autophagic substrate accumulation through ROS-dependent modulation of the AMPK/mTORC1 axis in Parkinson's disease.

The Integrated Stress Response Suppresses PINK1-dependent Mitophagy by Preserving Mitochondrial Import Efficiency

This study shows the integrated stress response (ISR) suppresses mitophagy by maintaining mitochondrial import efficiency, independent of ATF4, under non-depolarizing stress.

OEP24.1 involved in carbon allocation is a receptor of piecemeal plastid autophagy in Arabidopsis

This study identifies OEP24.1 as a receptor mediating piecemeal plastid autophagy in Arabidopsis, linking it to carbon allocation and chloroplast quality control.

Biallelic WDR91 variants cause a neurodevelopmental disorder through impaired endosomal maturation and autophagy dysregulation

The paper identifies biallelic WDR91 variants causing a neurodevelopmental disorder by impairing endosomal maturation and autophagy.

Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast

This study identifies Npr1 as a nucleophagy receptor in fission yeast and shows that chromatin-nuclear envelope tethering inhibits nucleophagy.

Rab12 is a regulator of mitophagy and mitochondrial homeostasis

This study identifies Rab12 as a negative regulator of mitophagy and mitochondrial homeostasis, showing its loss increases mitochondrial clearance and sensitivity to stress.

In situ visualization of autophagy suggests vesicle fusion can contribute to phagophore expansion

This study uses cryo-electron tomography to show that vesicle fusion contributes to phagophore expansion in yeast during autophagosome biogenesis.

Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder

The paper identifies bi-allelic ATG12 variants causing a neurodevelopmental disorder by impairing autophagy, with clinical and functional evidence from patient cells, yeast, and zebrafish models.

Autophagy deficiency in red pulp macrophages impairs their function and resistance to iron stress

This study shows that autophagy deficiency in red pulp macrophages leads to impaired function and increased susceptibility to iron stress.

Dysregulation of a novel autophagosome-mitochondria contact contributes to autophagy dysfunction and neurodegeneration in tauopathy

This study identifies dysregulated autophagosome-mitochondria contacts in tauopathy, showing that restoring these contacts improves autophagy and reduces tau pathology.