Neurogenesis and neuroplasticity mechanisms

The paper shows that transplanted inhibitory neurons induce but do not maintain ocular dominance plasticity in the host visual cortex.

This study examines the effects of fluoxetine on hippocampal neurons and cortical neurogenesis in marmosets, finding increased immature neuron markers and changes in interneurons.

This study identifies Notch2 and Id4 as regulators of neural stem cell quiescence in the adult hippocampus, showing their role in maintaining dormancy and affecting neurogenesis.

The paper shows Bcl6 promotes neurogenic conversion by repressing extrinsic self-renewal pathways like Wnt through transcriptional silencing.

This study identifies LncKdm2b as a lncRNA that cis-activates Kdm2b to regulate cortical neuronal differentiation through chromatin remodeling.

This study uses 2-photon imaging to show that neuronal integration in the adult olfactory bulb occurs without cell loss and without a critical period, challenging the turnover model.

This study shows that Fbxw7 loss enhances Schwann cell myelinating potential by altering mTOR signaling and enabling multiple axon myelination, challenging previous distinctions between myelinating and non-myelinating Schwann cells.

This study shows that ASH2L regulates Wnt-β-catenin signalling in NPCs, affecting their proliferation and neuronal positioning during corticogenesis.

The paper uses live imaging and mathematical modeling to show HES5 protein dynamics correlate with cell-state transitions and fate decisions in murine neurogenesis.

This study shows that dihydrotestosterone increases new neuron survival in young male rats but not in middle-aged males or females.

The paper identifies Onecut and Pou2f2 transcription factors as regulators of V2 interneuron diversification and migration in the developing mouse spinal cord.

This study shows that increasing adult neurogenesis in rats reduces activity in developmentally-born dentate granule neurons, supporting an inhibitory role for new neurons in hippocampal function.

This study identifies transient basal protrusions in zebrafish spinal neurons that regulate spatiotemporal differentiation patterns through lateral inhibition.

This study shows that early-generated interneurons (EGIns) have more mature properties and significantly influence network synchronization and inhibitory synaptic transmission during early postnatal development.

This study develops a stochastic model linking cell cycle progression and differentiation in adult neural stem cells, showing that their coupling maintains tissue homeostasis.

The paper examines FOXP2 expression and function in mouse cortical development, finding that its removal does not disrupt many previously proposed developmental processes.

The paper shows that loss of Shh signaling in dorsal progenitors leads to oligodendrocyte depletion, which recovers through differential contributions from dorsal and ventral lineages, with gray matter OPCs failing to recover.

This study uses human pluripotent stem cell-derived cerebral organoids to show that oligodendrogenesis in the human brain has both ventral and dorsal origins, with dorsal cells dominating in fused organoids.

This study shows that Dpy30, a component of H3K4 methyltransferase complexes, is essential for maintaining self-renewal and differentiation of postnatal neural stem and progenitor cells.

This study shows that extracellular Pax6 non-cell autonomously regulates Cajal-Retzius cell migration in the developing mouse neocortex by affecting directionality, distance, and depth of migration.

The paper shows cerebellar folding arises from mechanical forces due to uniform cell behavior, not a cellular pre-pattern.

The paper identifies an Olig2-expressing astrocyte precursor subtype in the ventral spinal cord that depends on Sulf2 for its generation.

This study shows that Sufu regulates Shh signaling to control the expansion and quiescence of neural stem cells in the developing dentate gyrus.

The paper shows that adult zebrafish regenerate dopaminergic neurons, but this capacity varies between populations and depends on immune system activation.

This study investigates the effects of chronic letrozole treatment on hippocampal neurogenesis and depressive-like behavior in middle-aged female mice, finding increased neurogenesis without behavioral changes.

This study shows that PADI2-mediated citrullination is essential for oligodendrocyte differentiation, myelination, and motor function, with implications for remyelination therapies.

This study shows YAP activity is necessary and sufficient for basal progenitor proliferation and abundance in the developing neocortex, linking it to neocortical expansion during evolution.

The paper uses single-cell transcriptomics to analyze how Amyloid-beta42 and Interleukin-4 affect neural stem/progenitor cell plasticity in adult zebrafish brain, identifying gene expression changes and cell-cell communication alterations.

This study shows that cerebral organoids cultured at the air-liquid interface form functional nerve tracts with diverse morphologies and connectivity.

This study investigates the regenerative capacity of quiescent radial-glial stem cells in the zebrafish tectum, showing that lesion-induced proliferation and neurogenesis occur through distinct progenitor populations and are Wnt-independent.