Retinal Development and Disorders

Müller glia subtypes define neuro-glial associations and spatial morphogen axes in the zebrafish retina

The paper identifies three constitutive Muller glia subtypes in the zebrafish retina that define spatial morphogen axes and neuron-associated programs, showing functional heterogeneity in the healthy retina.

GABAergic TH2 Amacrine Cells Participate in Spontaneous Wave Activity in the Developing Retina

This study identifies TH2 amacrine cells as active participants in retinal wave circuits during development, showing they are excited by starburst amacrine cells and later driven by bipolar cells through cholinergic and glutamatergic waves.

Immune regulation of neuronal stem cells in the medaka retina

The paper shows microglia phagocytose medaka retinal stem cells under homeostasis, but Ccl25b-Ccr9a signaling is not essential for their maintenance.

A mutation-agnostic and allele-specific ASO strategy demonstrates potent functional rescue and retinal preservation in RHO-linked retinitis pigmentosa

This paper develops an allele-specific ASO strategy, SNARE, that selectively suppresses mutant RHO transcripts in RHO-linked retinitis pigmentosa, demonstrating functional rescue and retinal preservation in both in vitro and in vivo models.

Retinal degeneration in a mouse model of CRB1 disease rescued by the photoreceptor-specific CRB1-B isoform

This study shows that restoring the CRB1-B isoform in photoreceptors rescues retinal degeneration in a mouse model of CRB1 disease by preserving adherens junctions.

Alcama expressed in blood retina barrier and Muller glia is involved in zebrafish retina regeneration

This study investigates Alcama's role in zebrafish retina regeneration by examining its expression and knockdown effects on regeneration processes.

Generation of a new immunodeficient rat model of retinal degeneration with LSL TdTomato reporter and TdTomato-Pcp2 expression

The paper develops a new immunodeficient rat model of retinal degeneration with fluorescent labeling for studying retinal transplantation and connectivity.

Evidence for a rod-to-cone lactate shuttle in the mammalian retina

The paper demonstrates that lactate produced by rod photoreceptors supports cone photoreceptor function and viability through a rod-to-cone lactate shuttle, suggesting new therapeutic avenues for retinal diseases.

The Rod Bipolar Cell Pathway Contributes To Surround Responses In OFFRetinal Ganglion Cells

The paper identifies rod bipolar and AII amacrine cells as key to surround responses in OFF retinal ganglion cells through optogenetics and electrophysiology.

Genome sequencing reveals novel pathogenic deep-intronic PCDH15 variants, amenable to antisense oligonucleotide-based splice correction

The paper identifies two novel deep-intronic PCDH15 variants in Usher syndrome patients and demonstrates the efficacy of antisense oligonucleotides in correcting their splicing defects.

Expression status transition of NOTCH1 accompanies chromatin remodeling in human early retinal progenitor cells

The paper examines NOTCH1 expression changes in human retinal progenitor cells and links them to chromatin remodeling using single-cell RNA-seq and ATAC-seq data.

VCP inhibition preserves photoreceptor integrity under hydroquinone-induced oxidative stress in a human iPSC-RPE/porcine neuroretina co-culture model

This study shows that VCP inhibition with ML240 protects photoreceptors from hydroquinone-induced oxidative stress in a human iPSC-RPE/porcine neuroretina co-culture model.

Reelin coordinates neuronal positioning and Müller glia scaffold maturation during retinal development

This study shows Reelin regulates retinal lamination by coordinating neuronal positioning and Müller glia scaffold maturation in mice.

Photoreceptor-derived FGF2 mediates a protective stress response without driving pathological retinal neovascularization in ischemic retinopathy

This study identifies rod photoreceptors as a source of FGF2 during ischemic retinopathy, showing it promotes photoreceptor survival without driving pathological neovascularization.

Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factors

The paper identifies NEUROD1 as a factor that, when combined with ASCL1, bFGF, and an Activin A inhibitor, can reprogram human RPE into photoreceptor-like cells.

A retinal adrenergic module tunes mammalian visual evolution

The paper identifies an evolutionarily mobile adrenergic module in the mammalian retina that modulates visual function across species.

A pooled genetic approach provides multimodal access to uncharacterized retinal ganglion cell subtypes

The paper identifies and characterizes four uncharacterized retinal ganglion cell subtypes using a combination of genetic labeling, molecular, morphological, and functional analyses.

The extreme diversity of retinal amacrine cells has deep evolutionary roots

The paper reconstructs the evolutionary origins of retinal amacrine cell diversity using transcriptomic data from 24 vertebrate species, identifying 42 orthologous cell types and suggesting a hybrid precursor origin.

Metabolic signatures of cone-dominant and cone-degenerating retinas

This study identifies metabolic changes in cone-dominant and cone-degenerating retinas, revealing key metabolites associated with cone abundance and metabolic vulnerabilities in retinal degeneration.

Photostimulation Improves Maturation of Human Photoreceptors

This study shows that rhythmic light flicker improves photoreceptor maturation in human retinal organoids by enhancing structural development, transcriptional transition, and functional connectivity.

Lineage tracing reveals atoh7 positive and negative retinal ganglion cell populations in the zebrafish retina

The paper uses lineage tracing in zebrafish to identify atoh7 positive and negative retinal ganglion cell populations, showing 79% of RGCs originate from atoh7+ progenitors.

A gene-augmentation framework for selected early-stage autosomal recessive retinitis pigmentosa genotypes

The paper identifies tractable genes for gene-augmentation therapy in autosomal recessive retinitis pigmentosa using AAV vectors and evaluates PDE6B in animal models.

Subfunctionalization of tbx2 paralogues during photoreceptor cell specification in zebrafish

The paper shows that tbx2a and tbx2b subfunctionally regulate photoreceptor cell fate in zebrafish, with tbx2b promoting sws1 cone differentiation and tbx2a involved in regeneration.

A large-scale dataset of functional mouse ganglion cell layer responses

The paper introduces a large-scale dataset of functional responses from mouse ganglion cells, enabling population-level analyses and computational modeling of retinal computation.

Loss of ABCA4 from photoreceptor discs triggers changes in glial cell homeostasis

This study uses hiPSC-derived retinal organoids to show that ABCA4 loss in photoreceptors disrupts glial cell homeostasis, suggesting a role for glial cells in Stargardt disease progression.

PEDF/PEDF-R Signaling Regulates Retinal Phospholipid Homeostasis and Photoreceptor Survival

This study shows that PEDF/PEDF-R signaling regulates retinal lipid homeostasis and photoreceptor survival through altered lipid metabolism and connectivity.

Nrl expression and promoter activity in developing cone photoreceptors

This study shows the Nrl promoter is active in both rod and cone photoreceptors, challenging its use as a rod-specific marker and suggesting flaws in current gene regulatory network models.

Zebrafish prph2a/b and rom1a/b serve distinct functions during cone and rod outer-segment assembly.

This study investigates the distinct roles of prph2a/b and rom1a/b in zebrafish photoreceptor outer-segment assembly, showing prph2a/b are critical for cone OSs while rom1a/b are essential for rod OSs.

Dchs2, a novel Fat4 ligand, is required for photoreceptor organization and outer limiting membrane integrity in the mouse retina

Müller glia-vasculature interactions in the developing retina

This study investigates Müller glia-vascular interactions in the developing mouse retina, finding that calcium signaling at the glial-vascular interface is independent of spontaneous neuronal activity.