Cell Adhesion Molecules Research

METCAM/MUC18 plays a tumor promoter role in the development of nasopharyngeal carcinoma type III

The paper investigates the role of huMETCAM/MUC18 in NPC-TW04 cells, finding it promotes tumorigenesis by enhancing motility, invasiveness, and anti-apoptosis.

Isolation and Characterization of Antibodies Against VCAM-1 Reveals Putative Role for Ig-like Domains 2 and 3 in Cell-to-Cell Interaction

The paper identifies antibodies against VCAM-1 domains 2 and 3 that block macrophage adhesion, suggesting these domains are involved in cell-to-cell interactions.

Endothelial β1 Integrins are Necessary for Microvascular Function and Glucose Uptake

This study shows that endothelial β1 integrins are essential for microvascular function and glucose uptake during insulin stimulation.

Calcium-modulated cis and trans E-cadherin EC1-2 interactions play a key role in formation, dynamics and plasticity of cadherin junctions

This study investigates how calcium modulates E-cadherin EC1-2 interactions to form and regulate cadherin junctions using cryo-EM and tomography.

Structural insights into the molecular recognition of integrin αVβ3 by RGD-containing ligands: The role of the specificity-determining loop (SDL)

This study analyzes the molecular interactions and structural changes of integrin αVβ3's ligand-binding domain to identify key residues and allosteric mechanisms involved in ligand recognition and regulation.

Tumor-induced endothelial RhoA activation mediates tumor cell transendothelial migration and metastasis

This study identifies endothelial RhoA activation as a key driver of tumor cell transendothelial migration and metastasis, showing it can be inhibited to reduce metastatic potential.

Family-Wide Photoproximity Profiling of Integrin Protein Social Networks in Cancer

This study develops a method to detect integrin-centered protein interactions in live cells and identifies specific binding partners associated with cancer metastasis and disease outcomes.

Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin activation and FAK

This study shows that Tenascin-C promotes early lung cancer progression by activating integrins and FAK in mouse models and human lung adenocarcinomas.

Biomimetic Virus-Like Particles to control cell functions

This paper develops virus-like particles (VLPs) displaying ECM peptides to control cell functions and demonstrates their effectiveness in promoting adhesion, migration, proliferation, and differentiation.

Comment to: "Topology of molecular deformations induces triphasic catch bonding in selectin-ligand bonds"

The paper challenges mathematical claims about the physical mechanisms of selectin-ligand catch bonding in protein interactions.

IL-13 and IL-17A Activate β1 Integrin through an NF-κB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle

This paper shows IL-13 and IL-17A activate β1 integrins through an NF-κB/Rho kinase/PIP5K1γ pathway, enhancing force transmission in airway smooth muscle and linking this to asthma pathology.

An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer.

This paper identifies an integrin-centered membrane complex in breast cancer cells that regulates f-actin organization and migration through ion transport proteins, with implications for therapeutic targeting of triple-negative breast cancer.

Hotwiring integrin endocytosis acutely modulates cell interactions

This study uses hot-wired endocytosis to acutely downregulate 5{beta}1 integrins, showing reduced cell area, fibronectin uptake, and slower tumor spheroid compaction.

Comprehensive characterization of the integrin family across 32 cancer types

This study characterizes integrin family alterations across 32 cancer types, identifies integrinScore as a prognostic marker, and proposes potential therapeutic targets.

Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues

The paper investigates how collagen and DDR-2 signaling coordinate integrin adhesion between adjacent tissues in C. elegans.

LINKIN-associated proteins necessary for tissue integrity during collective cell migration

The paper identifies new interactors of LINKIN (ITFG1) and shows their role in cell migration and tissue integrity in C. elegans and human breast cancer cells.

A Dystroglycan-Laminin-Integrin axis controls cell basal geometry remodeling in the developing Drosophila retina

The paper identifies a Dystroglycan-Laminin-Integrin axis that directs cell basal geometry remodeling in the developing Drosophila retina by patterning the basement membrane.

Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2

This study identifies nidogen-2 as a physical and genetic interaction partner of hemicentin-1, showing their cooperative role in basement membrane integrity.

Genetic Analysis Suggests a Surface of PAT-4 (ILK) that Interacts with UNC-112 (kindlin)

The paper identifies a surface on PAT-4 that interacts with UNC-112 through genetic analysis in C. elegans.

The role of integrins in Drosophila egg chamber morphogenesis

This study shows that integrin function is required for maintaining cellular organisation and shape during Drosophila egg chamber morphogenesis, but not for pre-follicle cell polarity.

Non-junctional Cadherin3 regulates cell migration and contact inhibition of locomotion via domain-dependent opposing regulations of Rac1.

This study shows that non-junctional cadherin3 regulates cell migration and contact inhibition of locomotion by oppositely controlling Rac1 through extracellular and cytoplasmic domains without cell-cell contact.

Structural basis of the differential binding of engineered knottins to integrins αVβ3 and α5β1

The paper determines the structures of engineered knottins 2.5F and 2.5D in complex with integrin αVβ3 and reveals structural mechanisms underlying their differential binding to αVβ3 and α5β1.

The Adaptor Protein Nck1, but not Nck2, Mediates Shear Stress-Induced Endothelial Permeability.

This study shows Nck1, but not Nck2, mediates shear stress-induced endothelial permeability through distinct signaling mechanisms.

Evolutionary rate covariation analysis of E-cadherin identifies Raskol as regulator of cell adhesion and actin dynamics in Drosophila

The paper uses evolutionary rate covariation analysis to identify genes coevolving with Drosophila E-cadherin, revealing novel regulators of cell adhesion and actin dynamics.

Analysis of the role of Nidogen/entactin in basement membrane assembly and morphogenesis in Drosophila

This paper investigates the role of Nidogen/entactin in basement membrane assembly and morphogenesis in Drosophila, showing tissue-specific requirements and functional domains of Ndg.

Integrin signaling downregulates filopodia in muscle-tendon attachment

The paper shows integrin signaling suppresses filopodia in Drosophila myotubes during muscle-tendon attachment, enabling actin machinery to form strong attachments.

Novel functions for integrin-associated proteins revealed by myofibril attachment in Drosophila

The paper identifies new functions of integrin-associated proteins in Drosophila myotendinous junctions, revealing their roles in regulating adhesion and mechanotransduction.

Integrin and ligand-independent PDGFr signaling synergistically contribute to directional migration of Xenopus mesendoderm

The paper shows that integrin adhesion and PDGFr signaling work together to drive directional migration of Xenopus mesendoderm cells without PDGF-A ligand.

Multiple functions for the catenin family member plakoglobin in cadherin-dependent adhesion, fibronectin matrix assembly and Xenopus gastrulation movements

This study shows plakoglobin is essential for morphogenetic events by regulating cell-cell and cell-matrix adhesion during Xenopus gastrulation.

ProLIF: a quantitative assay for investigating integrin cytoplasmic protein interactions and synergistic membrane effects on proteoliposomes

ProLIF quantitatively measures integrin-protein interactions in proteoliposomes using flow cytometry, enabling analysis of membrane effects on protein recruitment.