Cell Adhesion Molecules Research

Uncovering the role of laminin(lama5) in maintenance of epithelial identity and polarity in bilayer zebrafish epidermis during development

This study investigates the role of laminin 5 in maintaining epithelial polarity and identity in zebrafish epidermis, finding that its loss leads to mesenchymal traits and altered cell behavior.

α-Parvin regulation of cell re-arrangement is critical for ureteric bud branching morphogenesis

This study shows that α-parvin regulates cell rearrangements during ureteric bud branching by inhibiting cell adhesion and actin polymerization.

Shared ligand-blocking mechanism but distinct conformational modulation by α5-targeting antibodies BIIG2 and MINT1526A

This study compares two anti-α5β1 antibodies, showing they share ligand-blocking mechanisms but differ in conformational modulation, with implications for therapeutic design.

SNED1 fibrillar assembly in the extracellular matrix requires fibronectin and collagen I

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation

This study presents the high-resolution cryo-EM structure of integrin αIIbβ3 bound to an anti-HPA-1a antibody, revealing how it blocks integrin activation and platelet aggregation.

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity

The paper identifies a signaling axis involving SorLA, integrin, and HER2/HER3 that regulates apicobasal polarity in mucinous colorectal adenocarcinoma and shows its therapeutic relevance.

Integrins and tetraspanins mediate CD36-actin coupling and regulate CD36 organization and signaling

This study identifies integrins and tetraspanins as mediators of CD36-actin coupling, showing their role in CD36 organization and signaling in vascular endothelial cells.

Patterned integrin-laminin adhesion coordinates epithelial collective cell migration

The paper shows integrins 3 and 6, along with laminin 5, coordinate epithelial collective migration in zebrafish pLLP by maintaining basement membrane integrity and regulating protrusive activity.

Epithelial eversion, a collective rearrangement from apical-in to apical-out polarity, is initiated by α6β4 integrins and sustained by increased cell proliferation and anchorage-independence

This study identifies α6β4 integrins as initiators of epithelial eversion and shows that increased cell proliferation and anchorage-independence sustain apical-out polarity.

Adhesion-derived condensates control component availability to regulate adhesion dynamics

This study shows that TNS1 phase separation regulates adhesion dynamics by controlling the availability of inactive adhesion proteins through phosphorylation-dependent condensate formation.

Mindin mediated αM-Integrin endocytosis activates STAT3 to maintain keratinocyte stemness

The paper shows that Mindin-mediated αM-Integrin endocytosis activates STAT3 to maintain keratinocyte stemness.

The Lipid-binding PX Domain of RRC-1 (ARHGAP32/33) is Required for Optimal Assembly and Function of Integrin Adhesion Complexes at the Muscle Cell Boundary in C. elegans

The paper shows that the PX domain of RRC-1 is necessary for its localization to muscle cell boundaries and for proper integrin adhesion complex assembly and function in C. elegans.

Insulin-Like Growth Factor 1 Receptor Regulates Breast Cancer Cell Adhesion through Beta-1 Integrin

This study shows that IGF1R regulates breast cancer cell adhesion through β1 integrin, with both IGF-1 stimulation and IGF1R knockdown increasing adhesion by removing IGF1R from the cell surface.

E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activity

This study shows E- and N-cadherin regulate hepatic polarity and bile canaliculi formation through opposing effects on RhoA activity.

Regulation of reticular adhesions by KANK2 and talin2 in two melanoma cell lines

This study identifies KANK2 and talin2 in reticular adhesions of melanoma cell lines and shows their differential roles in RA composition.

KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism

This study shows KANK2 has distinct roles in focal adhesions and fibrillar adhesions, regulating their maintenance and cell migration via microtubule interactions.

A flow cytometry-based assay to quantify the binding of transmembrane ligands to their cognate receptors using fluorescent virus-like particles

This paper introduces a flow cytometry-based assay using fluorescent virus-like particles to quantify transmembrane ligand-receptor binding, showing it can study patient-derived variants and enable single-cell analysis of multiple interactions.

Bivalency of natalizumab promotes inhibition of dynamic VLA-4 adhesion beyond affinity gain

This study shows that bivalent natalizumab inhibits VLA-4 adhesion more effectively than monovalent Fab fragments under shear stress, suggesting kinetic and geometric factors are critical for therapeutic efficacy.

Two δ-Catenins, Plakophilin 4 and p120, Promote Formation of Distinct Types of Adherens Junctions

This study identifies how p120 and plakophilin 4 regulate distinct adherens junction types through different cadherin clustering mechanisms in epithelial cells.

Integrin α5β1 mediates the inhibitory effects of vasoinhibin on angiogenesis and vascular permeability

This study identifies integrin α5β1 as the receptor for vasoinhibin's HGR motif, revealing its role in inhibiting angiogenesis and vascular permeability through integrin activation.

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in C. elegans

This study shows that NPxY motifs in C. elegans pat-3 β integrin modulate serotonin sensitivity and mechanosensation by affecting vulval contraction and neurotransmitter levels.

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The paper identifies the CD9 interactome in epithelial cells during bacterial infection, showing species-specific interactions and demonstrating a CD9-derived peptide can block bacterial adherence.

Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins

The paper investigates the evolutionary origin and structural role of the I domain in integrin proteins, showing it mimics ligands to enable activation and expand cellular communication.

TNF-a induces VE-cadherin-dependent gap/JAIL cycling through an intermediate state essential for neutrophil transmigration

This study shows TNF-α induces an inflammatory morphological phenotype (IMP) through VE-cadherin-dependent gap/JAIL cycling, essential for neutrophil transmigration.

Leukocytes use endothelial membrane tunnels to extravasate the vasculature

The paper shows that neutrophils use endothelial membrane tunnels for paracellular extravasation, formed by membrane lifting and indentation without requiring PECAM-1 or VE-cadherin.

Prediction of αIIbβ3 integrin structures along its minimum free energy activation pathway

This paper predicts the structures of αIIbβ3 integrin along its minimum free energy activation pathway using a computational method, revealing correlated subdomain movements and providing insights for therapeutic design.

The kinesin KIF3AC recycles endocytosed integrin to polarize adhesion formation towards the leading edge

This study identifies KIF3AC and RCP as essential for recycling integrin from disassembled focal adhesions to promote polarized FA formation at the leading edge of migrating fibroblasts.

The scaffold protein CasL regulates T cell migration by restricting membrane blebbing

This study identifies CasL as a regulator of T cell migration by controlling membrane blebbing during integrin-dependent movement into inflamed tissue.

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

Molecular Basis of β2 Integrin Activation by Talin Unveils Species-Specific Mechanisms of Integrin Signaling

This study determines the crystal structure of talin head bound to β2-integrin tail, revealing species-specific mechanisms of integrin activation through a two-mode binding configuration.