Cell Adhesion Molecules Research

IPMK-1 (inositol phosphate multikinase) is required for optimal integrin adhesion complex assembly in C. elegans muscle

This paper identifies ipmk-1 as a genetic enhancer of the PIX-1 pathway in C. elegans muscle, showing that PIP3 and PIP2 levels affect integrin adhesion complex assembly.

TNF-a induces VE-cadherin-dependent gap/JAIL cycling through an intermediate state essential for neutrophil transmigration

This study shows TNF-α induces an inflammatory morphological phenotype (IMP) through VE-cadherin-dependent gap/JAIL cycling, essential for neutrophil transmigration.

Leukocytes use endothelial membrane tunnels to extravasate the vasculature

The paper shows that neutrophils use endothelial membrane tunnels for paracellular extravasation, formed by membrane lifting and indentation without requiring PECAM-1 or VE-cadherin.

Prediction of αIIbβ3 integrin structures along its minimum free energy activation pathway

This paper predicts the structures of αIIbβ3 integrin along its minimum free energy activation pathway using a computational method, revealing correlated subdomain movements and providing insights for therapeutic design.

Triple-helical ligands selectively targeting the closed αI domain of integrin α2β1

The paper identifies triple-helical peptides that selectively bind the closed α2I domain of integrin α2β1 without requiring Glu or metal ions, revealing a new binding mode.

The kinesin KIF3AC recycles endocytosed integrin to polarize adhesion formation towards the leading edge

This study identifies KIF3AC and RCP as essential for recycling integrin from disassembled focal adhesions to promote polarized FA formation at the leading edge of migrating fibroblasts.

Investigation of CD36 interactome provides insights into multimolecular complexes necessary for anti-angiogenic signalling

The paper investigates CD36 interactome to identify multimolecular complexes involved in anti-angiogenic signaling through proximity biotinylation and functional assays.

The scaffold protein CasL regulates T cell migration by restricting membrane blebbing

This study identifies CasL as a regulator of T cell migration by controlling membrane blebbing during integrin-dependent movement into inflamed tissue.

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

Modulation of collagen-binding integrins affects fibroblast activation and inhibits fibrosis

This study shows that modulating collagen-binding integrins can reduce fibrosis by inhibiting fibroblast activation in both liver and lung models, with differing mechanisms depending on the tissue.

Ivermectin binds to the allosteric site (site 2) and inhibits allosteric integrin activation by pro-inflammatory cytokines.

This study shows ivermectin binds to the allosteric site 2 of integrins and inhibits their activation by pro-inflammatory cytokines, similar to anti-inflammatory cytokines.

Molecular Basis of β2 Integrin Activation by Talin Unveils Species-Specific Mechanisms of Integrin Signaling

This study determines the crystal structure of talin head bound to β2-integrin tail, revealing species-specific mechanisms of integrin activation through a two-mode binding configuration.

Integrin promotes basement membrane crossing and branching of an invading intracellular tube

This study shows integrins and basement membrane regulate branching of an intracellular tube in C. elegans by analyzing lumen formation and genetic mutants.

Inducible FAK Deletion but not FAK Inhibition in Endothelial Cells Activates p53 to Suppress Tumor Growth in PYK2-null Mice

The paper shows that deleting FAK in endothelial cells of PYK2-null mice activates p53, suppresses tumor growth, and limits metastasis, while FAK inhibition has different effects.

A Bioinformatic Investigation into the Role of ITGB1 in Cancer Prognosis and Therapeutic Resistance

This study uses bioinformatics to analyze ITGB1 expression across cancers, finding its upregulation correlates with poor prognosis and therapeutic resistance.

The EC2 domains of tetraspanins CD9, CD81, and CD151 bind to the allosteric site of integrins (site 2) and activate integrins αvβ3, α5β1 and α4β1 in a biphasic manner.

Neuropilin 2 stabilises adherens junctions and protects against endothelial activation by promoting the interaction between VE cadherin and p120 catenin

This study shows that Nrp2 stabilizes adherens junctions in endothelial cells by promoting VE cadherin-p120 catenin interaction, preventing endothelial activation and vascular disease.

Multivalent Afadin Interaction Promotes IDR-Mediated Condensate Formation and Junctional Separation of Epithelial Cells

This study shows that afadin's multivalent interactions drive IDR-mediated condensate formation, promoting AJC formation and junctional separation in epithelial cells.

Structural insights into the in situ assembly of clustered protocadherin γB4

This study investigates the in situ assembly of cPcdh-γB4 using electron tomography, revealing distinct roles of ectodomain and intracellular domain in intermembrane organization.

A Machine Learning-Based Investigation of Integrin Expression Patterns in Cancer and Metastasis

The paper uses machine learning to analyze integrin expression patterns in cancer and metastasis, identifying key integrins that distinguish tissue types and disease states.

Inhibiting fibronectin assembly in the breast tumor microenvironment increases cell death and improves response to doxorubicin

Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody.

This study shows that an antibody can trigger cadherin endocytosis by stabilizing an X-dimer conformation, leading to lysosomal targeting and providing a mechanism for intracellular drug delivery.

The IQGAP-related RasGAP IqgC regulates cell-substratum adhesion in Dictyostelium discoideum

This study identifies IqgC as a positive regulator of cell-substratum adhesion in Dictyostelium discoideum, showing its role in adhesion complex formation and signaling through RapA.

VE-cadherin RGD motifs are dispensable for cell-cell junctions, endothelial barrier function and leukocyte extravasation

This study shows that VE-cadherin RGD motifs are not essential for endothelial cell-cell junctions, barrier function, or leukocyte extravasation.

A subpopulation of Talin 1 resides in the nucleus and regulates gene expression

This study identifies a nuclear subpopulation of Talin 1 that regulates gene expression in human breast epithelial cells.

Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets

The paper shows that Invasin-coated plates enable long-term 2D expansion of epithelial organoids from multiple species, offering an alternative to Matrigel/BME.

The novel ECM protein SNED1 mediates cell adhesion via the RGD-binding integrins α5β1 and αvβ3

This study identifies SNED1 as an ECM protein that promotes cell adhesion in breast cancer and neural crest cells through interactions with integrins α5β1 and αvβ3.

Talin1 dysfunction is genetically linked to systemic capillary leak syndrome.

The paper identifies a rare TLN1 splice-site variant in a familial SCLS case, linking Talin1 dysfunction to systemic capillary leak syndrome through disrupted endothelial barrier integrity.

Macrophage migration-dependent retraction fibers and migrasomes - a structural basis for spatiotemporal cytokine secretion.

This study identifies retraction fibers and migrasomes as cytokine secretion sites in migrating macrophages, revealing a structured mechanism for spatiotemporal cytokine release.

Superresolution Imaging Reveals the Spatial Organization of CD81 Microdomains in Regulating Membrane Signaling on Jurkat T Cell Microvilli

The paper uses superresolution imaging to show CD81 microdomains are organized on T cell microvilli and interact with TCR and CD63, suggesting a role in regulating membrane signaling.