Trace Elements in Health

Systematic characterization of zinc in a series of breast cancer cell lines reveals significant changes in zinc homeostasis

This study measures zinc levels in breast cancer cell lines and finds differences in zinc homeostasis affecting proliferation and viability.

Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury

This study shows that CTR1 contributes to retinal ischemia-reperfusion injury by promoting oxidative stress and inflammation, and that copper chelators like TTM can mitigate these effects.

Epithelium intrinsic zinc sensor controls immune homeostasis with gut microbes via regulation of Tuft cell lineage

This study shows that zinc sensing via MTF1 in intestinal epithelial cells regulates Tuft cell lineage and immune homeostasis with gut microbes.

Excessive zinc reduces histone acetylation in mouse cardiomyocytes by downregulating acetyltransferases

This study shows excessive zinc reduces histone acetylation in mouse cardiomyocytes by downregulating acetyltransferases, not deacetylases, and links this to reduced Bmp4 expression.

Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

The paper investigates how neuronal cells adapt to copper deficiency by increasing protein synthesis through mTORC1 activation and reduced PERK signaling in multiple model systems.

Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis

This study shows that endothelial CTR1 senses disturbed flow by increasing mitochondrial copper, leading to cuproptosis and atherosclerosis, and identifies a therapeutic target.

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

The paper identifies SLC39A5 as a gene whose loss-of-function variants are associated with reduced type II diabetes risk and improved liver function in metabolic disorders.

Cysteine Rich Intestinal Protein 2 is a copper-Responsive regulator of skeletal muscle differentiation.

This study identifies mCrip2 as a copper-responsive regulator of skeletal muscle differentiation through functional and biochemical analyses in murine myoblasts.

Role of copper during microglial inflammation

The paper investigates how copper levels affect microglial inflammation, finding that both excess and deficiency disrupt immune responses to LPS.

Determination of metal ion transport rate of human ZIP4 using stable zinc isotopes

This paper determines the turnover number of human ZIP4 using stable zinc isotopes and ICP-MS, finding it ranges from 0.08 to 0.2 s-1.

Developmental regulation of zinc homeostasis in differentiating oligodendrocytes

The paper investigates zinc homeostasis changes during oligodendrocyte differentiation using zinc sensors and gene expression analysis, finding dynamic regulation of zinc levels and storage proteins.

Glial swip-10 expression controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis

This paper identifies swip-10's role in systemic copper homeostasis in C. elegans, linking it to mitochondrial function, oxidative stress, and neurodegeneration.

Cellular zinc status alters chromatin accessibility and binding of transcription factor TP53 to genomic sites

The paper shows that changes in labile zinc levels affect chromatin accessibility and TP53 binding to DNA.

The role of intestine in metabolic dysregulation in murine Wilson disease

This study investigates the role of the intestine in metabolic dysregulation in murine Wilson disease by analyzing gut microbiota and lipidome in mouse models.

Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn2+ uptake into the Golgi apparatus

The paper presents cryo-EM structures of human ZnT7, revealing its mechanism for Zn2+ uptake into the Golgi apparatus through conformational changes and histidine-rich loop interactions.

Copper imbalance linked to oxidative stress and cell death during Zika virus infection in human astrocytes

This study shows that ZIKV infection disrupts copper homeostasis in human astrocytes, leading to oxidative stress and cell death, and that copper chelation can reduce oxidative stress and improve cell viability.

A study of Mutation in ATP7B gene and its correlation with clinical phenotype and radiological features in Wilson Disease patients

This study examines mutations in the ATP7B gene in Wilson Disease patients in eastern India, correlating them with clinical and radiological features using machine learning.

Wilson disease: intersecting DNA methylation and histone acetylation regulation of gene expression in a mouse model of hepatic copper accumulation

This study investigates how DNA methylation and histone acetylation changes in a mouse model of Wilson disease are influenced by diet and copper chelation, revealing their role in regulating gene expression in metabolic pathways.

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content

This study shows that Golgi-dependent copper homeostasis, mediated by ATP7 and COG, is essential for maintaining mitochondrial function and synaptic integrity in neurons.

Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans

The paper identifies a gene, sqst-5, associated with zinc resistance in C. elegans by analyzing genetic variation between strains with different zinc responses.

Zinc oxide nanoparticles modulate the gene expression of ZnT1 and ZIP8 to manipulate zinc homeostasis and stress-induced cytotoxicity in human neuroblastoma SH-SY5Y cells

This study shows that low concentrations of ZnO-NP elevate [Zn2+]c, modulate ZnT1 and ZIP8, and reduce 6-OHDA-induced cytotoxicity in SH-SY5Y cells.

Copper Induces Zebrafish Central Neural System Myelin Defects: the Regulatory Mechanisms in Wnt/Notch-hoxb5b Signaling and Underlying DNA Methylation

This study identifies copper-induced myelin defects in zebrafish via disruption of Wnt/Notch-hoxb5b signaling and DNA methylation of fam168b/pou3f1 genes.

Zinc deficiency decreases bone mineral density of rat by calmodulin-induced change in calcium metabolism

This study shows zinc deficiency in rats reduces bone mineral density by altering calcium metabolism through calmodulin decrease and increased PTH.

Linkage of a plasma zinc signature and impaired insulin receptor activation: Implications for the mechanism of type 2 diabetes mellitus

The paper investigates the link between plasma zinc levels and insulin receptor activation in T2DM, finding that bacterial proteinases trapped by A2M impair insulin receptor function.

Brain-derived neurotrophic factor and TrkB levels in mice that lack vesicular zinc: Effects of age and sex

This study measures BDNF and TrkB levels in ZnT3 knockout mice across ages and sexes, finding no difference in protein levels but sex-specific mRNA expression changes.

Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc

This study examines the effects of environmental enrichment on neuronal morphology in ZnT3 knockout mice, finding no modulation of enrichment effects by ZnT3 absence.

The pharmacological perturbation of brain zinc impairs BDNF-related signalling and the cognitive performances of young mice

This study shows that reducing brain zinc levels with clioquinol impairs memory and BDNF-related signaling in young mice.