Ion Channels and Receptors

TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner

This study shows TRPM7 is essential for human CD4 T-cell activation and differentiation through Mg2+ dependent Ca2+ signaling and NFAT translocation.

Mechanically-gated currents in mouse sensory neurons lacking PIEZO2

This study examines mechanosensitive currents in sensory neurons lacking PIEZO2, finding no significant reduction in current sensitivity but a moderate decrease in rapidly adapting currents.

Targeting Tmem63b and Piezo2 in C-fiber low threshold mechanoreceptor: limitation of Vglut3-IRES-Cre

The paper evaluates the Vglut3-IRES-Cre mouse line for identifying non-PIEZO2 mechanosensors in C-LTMRs, finding it labels these neurons but fails to efficiently delete genes like Tmem63b.

Evolution of temperature dependence of TRPM2 channel gating and inactivation in vertebrates

This study compares temperature sensitivity of TRPM2 channels in zebrafish and human, finding that human TRPM2 gating evolved to be temperature dependent while inactivation was already temperature sensitive in early vertebrates.

Plasma membrane-endoplasmic reticulum coupling probed with genetically-encoded voltage sensors

This paper introduces genetically-encoded voltage sensors to measure ER membrane potential and shows voltage changes in the ER are directly coupled to plasma membrane voltage steps.

Twist is the key to the gating of mechanosensitive ion channel NOMPC

This study identifies torque on the TRP domain as the primary driver of NOMPC channel opening, revealing a twist-to-open mechanism facilitated by AR domain compression-twist coupling.

Fatty Acid Pathways Regulate Thermal Nociception in Caenorhabditis elegans

This study shows that fatty acid metabolism affects thermal nociception in C. elegans by linking PUFA biosynthesis to heat avoidance behavior.

A single residue determines regulation of TRPV1 by phosphoinositides

This paper identifies a single residue, H410, that determines how TRPV1 interacts with phosphoinositides, revealing a two-site binding mechanism for PI(4,5)P2 regulation.

Impaired store-operated Ca2+ entry in mouse epidermis leads to reduced epidermal barrier function via Klk activation.

This study shows that impaired store-operated Ca2+ entry in mouse epidermis causes reduced barrier function through Klk activation without affecting keratinocyte proliferation.

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

This study maps and functionally characterizes distinct vagal nociceptive afferent subsets in mice using intersectional genetics, revealing their unique innervation patterns and reflex responses.

Endothelial CYB5R3 couples store-operated calcium entry to TRPV2 activation and vascular fitness

This paper identifies CYB5R3 as a redox switch that couples store-operated calcium entry to TRPV2 activation, enhancing vascular function through NO-dependent oxidative inhibition of PTPN1.

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates

The paper shows that ER morphology affects neuronal bursting by controlling Ca2+ refill rates, linking ER structure to neuronal activity and neurodegeneration.

Basal cytoplasmic calcium levels regulate C. elegans germ stem cell proliferation

This study shows that basal cytoplasmic calcium levels regulate C. elegans germ stem cell proliferation through the GON-2 calcium channel and other calcium transport mechanisms.

Transduction mechanisms for cold temperature in mouse trigeminal and vagal ganglion neurons innervating different peripheral organs

This study identifies differences in cold sensing mechanisms between trigeminal and vagal neurons, highlighting TRPA1's role in visceral cold transduction and organ-specific sensitivity.

Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

This study shows rapamycin directly activates TRPM8 ion channels by binding to a novel site, distinct from known agonists, and highlights implications for drug development and research methods.

Calmodulin binding is required for calcium mediated TRPA1 desensitization

This study identifies a CaM binding element in TRPA1 that is essential for Ca2+-mediated desensitization and reveals a mechanism by which CaM regulates TRPA1 function.

Bleb-based extravasation: conserved morphodynamics, divergent calcium control

The paper shows that all extravasating cells form Ca²⁺-dependent membrane blebs, but the source of Ca²⁺ varies by lineage, highlighting distinct regulatory mechanisms.

A specialized cold sensing system in the naked mole-rat

This study identifies molecular changes in the naked mole-rat that enhance cold sensing through expanded TRPM8 expression and alternative cold detection mechanisms.

Harnessing Protein Unfolding for Thermosensing: Structural Insights from TRPV3

This study reveals a structural mechanism for thermosensing in TRPV3 channels, showing that extreme thermosensitivity arises from protein unfolding and dynamic changes rather than localized sensors.

Structural Basis of Cold and Menthol Sensing by TRPM8

This study presents cryo-EM structures and functional analyses of TRPM8 activation by cold and menthol, revealing mechanisms of cold sensing and menthol specificity.

A technique for evaluating calcium flux in primary airway tissue at single cell resolution

The paper develops a method to study calcium flux in primary human airway tissue at single-cell resolution using live imaging and machine learning analysis.

Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine

The paper identifies M308 in TRPV1's ARD as a functionally significant residue with implications for channel activity and splice variant expression.

Engineering Infrared Light Detection in Blind Human Retina Using Ultrasensitive Human TRPV1 Channels

This paper engineers human TRPV1 channels to detect near-infrared light by shifting their temperature sensitivity, enabling light-induced heat activation in retinal cells without immunogenicity issues.

STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling

This paper uses AI-guided simulations to study STIM1 TM-helix dimerization, revealing three coexisting configurations and reconciling conflicting experimental results.

A Synthetic Coolant (WS-23) in Electronic Cigarettes Disrupts Normal Development of Human Embryonic Cells

This study shows that WS-23, a synthetic coolant in e-cigarettes, disrupts human embryonic cell development by inhibiting pluripotency and inducing endoderm differentiation at nanomolar concentrations.

Evolutionary Adaptations of TRPA1 Thermosensitivity and Skin Thermoregulation in Vertebrates

The paper investigates the evolutionary role of TRPA1 in skin thermoregulation across vertebrates, finding it functions as a heat sensor in ectotherms and has evolved cold sensitivity in some mammals.

Experience-dependent reconfiguration of receptors at a sensory compartment regulates neuronal plasticity

The paper shows temperature experience modulates transcription and trafficking of thermoreceptors in C. elegans AFD neurons to regulate response plasticity.

Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function

The paper functionally characterizes 706 STIM1 EF-hand variants using overexpression fitness costs in human cells, revealing structural and functional constraints and implications for disease.

Methionine oxidation of TRPV2 regulates thermogenesis in brown adipocytes

This study shows methionine oxidation activates TRPV2 at body temperature, enhancing thermogenesis in brown adipocytes.

The Cornea Harbors a Tricellular Neuro-Immune Niche that Underpins Touch Sensation

The paper identifies a tricellular niche in the cornea involving macrophages, nerves, and Schwann cells that supports Piezo2-mediated touch sensation.