Ion Channels and Receptors

TRPV1 Defends the Healthy Murine Cornea against Staphylococcus aureus Adhesion Independently of Sensory Nerve Firing

This study shows TRPV1 protects murine corneas from S. aureus adhesion without requiring sensory nerve firing, unlike its role against P. aeruginosa.

Triple-Negative Breast Cancer Cells Activate Sensory Neurons via TRPV1 to Drive Nerve Outgrowth and Tumor Progression

This study shows TNBC cells activate sensory neurons via TRPV1, driving nerve outgrowth and tumor progression, with TRPV1 knockout reducing tumor growth and metastasis.

A neuropeptide-specific signaling pathway for state-dependent regulation of the mesolimbic dopamine system

This study identifies TRPC6 channels as mediators of neuropeptide-induced calcium signaling in VTA-DA neurons, showing state-dependent regulation of reward valuation and consummatory behavior.

Intradental mechano-nociceptors serve as sentinels that prevent tooth damage

This study identifies intradental high-threshold mechano-nociceptors that detect tooth damage, produce pain, and trigger protective reflexes.

Short RFamide and CFamide peptides as novel positive modulators of Acid-Sensing Ion Channel 3 with similar potentiating effects but different reversibility

The paper identifies two synthetic peptides that potently and selectively modulate ASIC3 activity, showing similar effects but differing in washout kinetics.

(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation

This study presents cryo-EM structures of TRPC5 bound to (-)-englerin A, revealing its binding site and mechanism of activation.

Coupling between acid-sensing ion channel 1a and the monocarboxylate transporter family shapes cellular pH response

The paper identifies a functional interaction between ASIC1a and MCT1 that modulates proton sensitivity and desensitization, showing its role in glioblastoma cell survival and mouse lifespan.

Mycobacterium tuberculosis sulfolipid-1 (Sl-1) increases the excitability of mouse and human TRPV1-positive sensory neurons in a YM254890-reversible fashion

This study shows that Mycobacterium tuberculosis sulfolipid-1 (SL-1) increases TRPV1-positive sensory neuron excitability through Gq/11 pathway activation and intracellular Ca2+ release.

Non-equilibrium Thermodynamics Modulate TRPV1 Channel Activation via Tissue Entropy Production

The paper develops a multiscale model showing that increased entropy production in inflamed tissue lowers TRPV1 channel activation temperature, linking thermodynamics to sensory excitability.

Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice

The paper investigates ER and perinuclear space dilations in prion-infected mice and identifies TRPV2 as a contributor to this phenomenon, which may relate to spongiform degeneration.

Resting calcium ion fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogramming

The paper shows that resting calcium fluxes prevent mitochondrial fragmentation and transcriptional changes in astrocytes by modulating ER stress and gene expression.

Every Piece of the Puzzle Matters: A Novel Zinc-Binding Site in the Luminal Domain of STIM1 Drives Clustering

The paper identifies a zinc-binding site in the luminal domain of STIM1 that promotes clustering and is essential for calcium influx activation.

Cold-sensing TRP channels and temperature preference modulate ovarian development in the model organism Drosophila melanogaster

This study shows that cold-sensing TRP channels and temperature preference influence ovarian development in Drosophila melanogaster by modulating reproductive dormancy.

TRPV4 Inhibition Reduces Cartilage Growth During Axolotl Limb Regeneration

The paper investigates the role of TRPV4 and PIEZO2 in axolotl limb regeneration, finding that TRPV4 inhibition reduces limb length without affecting cartilage differentiation.

TRPV2 and TRPM2 channels facilitate pulmonary endothelial barrier recovery after ROS-induced permeability

The structural basis of cold sensitivity

This study uses cryo-EM and HDX-MS to reveal structural changes in TRPM8 channels that underlie cold sensitivity and menthol activation.

A NaV1.8FlpO mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors

The paper introduces a new mouse line expressing FlpO recombinase specifically in NaV1.8-expressing sensory neurons, enabling selective intersectional targeting of C-fiber mechanoreceptors and nociceptors.

Functional characterization of the store-operated calcium entry pathway in naked mole-rat cells

This study functionally and pharmacologically characterizes the store-operated calcium entry pathway in naked mole-rat cells using both excitable and non-excitable cells.

Heat-off responses of epidermal cells sensitize Drosophila larvae to noxious inputs

This study shows that Drosophila larval epidermal cells, not nociceptors, mediate heat-induced sensitization to noxious stimuli through thermosensitive calcium responses involving Orai and Stim.

TRPM8 protein dynamics correlates with ligand structure and cellular function

This study links TRPM8 protein dynamics to ligand structure and cellular function using NMR, cheminformatics, and electrophysiology.

TRPV4 modulates substrate stiffness mechanosensing and transcellular pore formation in human Schlemm's canal cells

This study shows TRPV4 modulates substrate stiffness sensing and transcellular pore formation in Schlemm's canal cells, with implications for glaucoma treatment.

Multiple weak brakes act in concert to regulate STIM1 and control store-operated calcium entry

This study identifies four weak restraints that regulate STIM1 activity to control store-operated calcium entry, showing their concerted action prevents spontaneous activity and enables reversible activation.

Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids

This study identifies alternative splicing of TRPA1 as a key mechanism driving reduced electrophile sensitivity in S. flava, enabling adaptation to toxic Brassicales plants.

Trpv1-dependent Cacna1b gene inactivation reveals cell-specific functions of CaV2.2 channels in vivo

The paper investigates the cell-specific role of CaV2.2 channels in Trpv1-lineage neurons using Cacna1b gene inactivation and shows their involvement in heat hypersensitivity.

TRPV4 channel contributes to aortic root stiffening and atherosclerotic lesion development

This study identifies TRPV4 as a cellular stiffness sensor linking matrix stiffness and atherosclerosis using human tissues and a mouse model.

Discovery and isolation of novel capsaicinoids and their TRPV1-related activity

The paper identifies and isolates novel capsaicinoids from chilis, showing structural variations significantly impact TRPV1 activation and demonstrating non-pungent compounds modulate capsaicin's effects.

Calpain cleaves the carboxyl terminus of TRPV1 and modulates receptor tachyphylaxis

This study shows that calpain cleaves TRPV1's carboxyl terminus, reducing its membrane localization and increasing resistance to tachyphylaxis during repeated capsaicin exposure.

Investigating Mechanically Activated Currents from Trigeminal Neurons of Non-Human Primates

The paper characterizes mechanically activated currents in trigeminal neurons of non-human primates, identifying distinct neuronal subtypes and their functional properties.

Anoctamins mediate polymodal sensory perception and larval metamorphosis in a non-vertebrate chordate.

This study identifies Anoctamin proteins as essential for polymodal sensory perception and larval metamorphosis in the tunicate Ciona intestinalis.

Diverging roles of TRPV1 and TRPM2 in warm-temperature detection

This study investigates the distinct roles of TRPV1 and TRPM2 in warm-temperature detection using cultured mouse DRG neurons and behavioral assays, revealing their unique contributions to thermal perception and decision-making.