Ion Channels and Receptors

Integrated transcriptomics and proteomics define the TRP channel hierarchy in mouse cortex

The paper quantifies TRP channel expression in mouse cortex using transcriptomics and proteomics, revealing dominant subfamilies and low abundance of others.

Mouse behavioral genomics identifies Creld1 as a gatekeeper of somatosensation

The paper identifies Creld1 as a master regulator of somatosensation through postnatal CRISPR screening and behavioral assays in mice.

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3

This study identifies stereoselectivity and functional plasticity in the TRPM3 ligand-binding pocket using cryo-EM and functional analyses, revealing how ligand structure affects channel gating.

Identification and functional investigation of Octopus vulgaris TRPV channels as potential nociceptors in cephalopods

This study identifies and functionally validates TRPV channels in Octopus vulgaris as polymodal nociceptors using in silico analysis and heterologous expression in model organisms.

Cnpy1 is a candidate endoplasmic reticulum chaperone of Vomeronasal type 2 GPCRs.

This study identifies Cnpy1 as an ER chaperone essential for V2R GPCR function and Go neuron survival in mice.

A sensory - preoptic circuit drives capsaicin-induced hypothermia

The paper identifies POAVglut2 neurons in the preoptic area as critical for capsaicin-induced hypothermia by selectively silencing neuronal subtypes and assessing their contribution to the hypothermic response.

STIM1 and Endoplasmic Reticulum-Plasma Membrane Contact Sites Oscillate Independently of Calcium-Induced Calcium Release

The paper investigates STIM1 oscillations in mast cells and finds they occur independently of calcium oscillations and are regulated by ER-PM contact site dynamics.

Cromolyn inhibits PGE2-mediated sensitisation of TRPV1 in a GPR35-dependent manner in sensory neurons

The paper investigates how cromolyn, a GPR35 agonist, inhibits PGE2-induced TRPV1 sensitization in sensory neurons, supporting GPR35 as an anti-nociceptive target.

Combining automated patch clamp with optogenetics enables selective recording of DRG neurons subtypes

The paper develops a method combining automated patch clamp and optogenetics to selectively record from specific subtypes of mouse DRG neurons.

Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in Drosophila

This study shows that ether phospholipids modulate mechanosensory and thermosensory responses in Drosophila by affecting PIEZO and TRPA1 channels.

TRPV1-Mediated Delivery of Chloroprocaine, a Local Anesthetic with High pKa, Produces Pain-Selective Anesthesia Without Neurotoxicity

This study shows that chloroprocaine, a high-pKa local anesthetic, when delivered via TRPV1 channels, provides prolonged pain-selective anesthesia without neurotoxicity.

Log-linear scaling of TRPV4-KCNN4 transcripts tunes ROCK-dependent mechanotransduction in a DCIS progression model

The paper shows TRPV4 and KCNN4 mRNA levels log-linearly scale with motility in a DCIS progression model under stress, while bulk TRPV4 protein does not correlate with motility.

Taste preferences are influenced by temperature and the TRPM8 thermoreceptor

The paper investigates how temperature and the TRPM8 thermoreceptor affect taste preferences in mice, finding that temperature influences quinine and sugar licking differently in TRPM8-deficient mice.

Unique pore architecture underlies constitutive gating of human retinalTRPM1

The paper reports the first cryo-EM structure of human TRPM1 in a conducting state, revealing an unexpected domain-swapped pore architecture and constitutive gating mechanism.

Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain Syndrome

This study investigates the cell-specific roles of mutant TRPA1 in FEPS using mouse models, showing distinct contributions of neuronal and Schwann cell TRPA1 to pain mechanisms.

Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers

This study uses single-cell RNA sequencing to show that SOCE blockers BTP2 and CM4620 reduce cytotoxicity in CD8 T cells and NK cells while preserving anti-inflammatory programs in CD4 Tregs.

A neuronal pathway for the supraspinal relay of warm and cool sensation

The paper identifies a neuronal pathway in mice for relaying warm and cool sensations through the anterolateral tract, showing that specific neurons are tuned to innocuous temperature changes.

Distances and charges along the Orai1 nexus-TM3 interface control STIM1-binding and pore opening

The paper investigates how distances and charges at the Orai1 nexus-TM3 interface influence STIM1-binding and pore opening in the CRAC channel.

A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration

The paper identifies a TRPV4-dependent Ca2+ signaling pathway that regulates lamellipodia actin architecture and promotes cell migration through RhoA and formin-mediated actin assembly.

TRPC6 channel inhibition disturbs store-operated Ca2+ entry to delay proliferation in bladder cancer

This study shows TRPC6 inhibition reduces bladder cancer cell proliferation by disrupting store-operated Ca2+ entry and the PI3K/Akt/mTOR pathway.

Clonazepam activates the transient receptor potential melastatin 8 (TRPM8) ion channel

The paper shows clonazepam activates TRPM8 ion channels, which may explain its efficacy in treating burning mouth disorder.

Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues

This paper develops and tests ideal efficacy photoswitch ligands for TRPC4/5 channels, enabling precise spatiotemporally-controlled modulation in live tissues.

Structural mechanism of TRPC3 inhibition by a potent and selective antagonist

This study identifies a potent and selective TRPC3 inhibitor, GSK2820986A, and elucidates its binding mechanism through molecular dynamics and functional assays.

TRPV4 Inhibition by a Natural Product Mediates Analgesia

This study identifies AH001 as a potent TRPV4 inhibitor, revealing its mechanism and demonstrating its analgesic effects in pain models.

Terpenes as Modulators of Nociceptive Signaling: Behavioral and Molecular Insights from Caenorhabditis elegans

This study investigates the antinociceptive effects of four Cannabis sativa terpenes in C. elegans, showing their modulation of nociceptive responses and molecular pathways via TRPV-like and cannabinoid-like receptors.

GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception

This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.

Visual input drives diverse ER calcium signals in neurons in vivo

The paper measures ER calcium signals in Drosophila neurons in vivo and finds they vary by cell type, subcellular compartment, and stimulus, indicating active ER calcium processing.

TRPV3 channel activity helps cortical neurons stay active during fever

This study shows that TRPV3 channel activity helps cortical neurons maintain activity during fever by adjusting depolarization to meet spike thresholds.

3D-MINFLUX nanoscopy reveals distinct allosteric mechanisms for activation and modulation of PIEZO1 by Yoda1

This study uses 3D-MINFLUX nanoscopy and electrophysiology to show Yoda1 activates PIEZO1 through two distinct allosteric sites, revealing separate pathways for activation and modulation.

Agonism of mosquito and human transient receptor potential ankyrin 1 (TRPA1) channels by the natural drimane sesquiterpene cinnamodial

This paper investigates the agonism of mosquito and human TRPA1 channels by cinnamodial, comparing its potency and selectivity to other agonists and identifying potential binding sites.