Connexins and lens biology

Rod inputs arrive at horizontal cell somas in mouse retina solely via rod-cone coupling

The paper shows rod signals reach horizontal cell somas in mouse retina exclusively via gap junctions with cones, not through axonal transmission.

A 3D Endothelium-on-a-Chip Model Uncovers Cx43-Dependent Glycolytic Shift and Endothelial Barrier Dysfunction in Diabetic Kidney Disease

This study uses a 3D endothelium-on-a-chip model to show that Cx43-dependent glycolytic shifts contribute to endothelial barrier dysfunction in diabetic kidney disease.

Cell-to-cell signalling mediated via CO2: activity dependent axonal CO2 production opens Cx32 in the Schwann cell paranode.

The paper shows that CO2 produced in axons gates Cx32 hemichannels in Schwann cells, mediating neuron-to-glia signaling and affecting myelin conduction.

Promotion of new expression of connexin gene Cx46 (GJA3) in the cochlea after Cx26 (GJB2) deficiency

This study shows that Cx26 deficiency in the cochlea leads to increased Cx46 expression, which compensates by forming gap junctions in the same locations as Cx26.

Photomapping the electrically coupled networks of the thalamus and cortex

This paper introduces opto-δL, a method to identify and quantify electrical synapses, and applies it to map coupled networks in thalamic and cortical tissues.

Endothelial TRPV4/Cx43 Signaling Complex Regulates Vasomotor Tone in Resistance Arteries

This study shows TRPV4 activation modulates endothelial Cx43 hemichannels via S-nitrosylation, influencing Ca2+ levels and vasomotor tone in resistance arteries.

Expression and Function of Connexin 43 and Connexin 37 in the Murine Zona Glomerulosa

The paper examines connexin 43 and 37 expression and function in murine zona glomerulosa, finding that while these proteins are expressed, functional gap junctions are rare and do not significantly affect calcium signaling.

Model-based Evaluation of Connexin Hemichannel Permeability

The paper develops a method to quantify hemichannel permeability using fluorescence imaging, electrophysiology, and mathematical modeling, showing a significant increase in DAPI permeability for Cx26*A49E.

Analysis of mouse lens morphological and proteomic abnormalities following depletion of βB3-crystallin

This study establishes a mouse model of Crybb3 loss-of-function and identifies proteomic changes in the lens, including downregulation of multiple proteins and altered transcription factor activation.

Dopamine regulates the membrane potential and glycine release of AII amacrine cells via D1-like receptor modulation of gap junction coupling.

This study shows dopamine modulates AII amacrine cell membrane potential and glycine release through D1-like receptor regulation of gap junction coupling with ON cone bipolar cells.

4-Phenylbutyric acid modulates Connexin 43 expression restricting murine-β-coronavirus infectivity and virus-induced demyelination

This study shows that 4-PBA treatment reduces MHV-A59 infectivity and demyelination by preserving Cx43 and ERp29 expression in a murine model of MS.

GJB3, a gap junction gene, supports cell growth by mediating cystine uptake and regulating cellular stress pathways in SLC7A11 low adenocarcinomas

This study identifies GJB3 as a key gene in adenocarcinomas with low SLC7A11, showing it supports cell growth through cystine uptake and stress pathway regulation.

Electrical synapse molecular diversity revealed by proximity-based proteomic discovery

The paper identifies hundreds of Connexin-associated proteins in zebrafish electrical synapses, revealing molecular diversity and overlap with chemical synapse proteomes, and links these proteins to neurological disorders.

Ankyrin-B is required for the establishment and maintenance of lens cytoarchitecture, mechanics, and clarity

This study shows that ankyrin-B is essential for maintaining lens clarity, structure, and mechanics through its role in cytoskeletal and membrane organization.

The components of an electrical synapse as revealed by expansion microscopy of a single synaptic contact

The paper uses expansion microscopy to reveal the structural organization of electrical synapses in zebrafish Mauthner cells, showing multiple gap junctions and their association with adherens junction components.

Synchronicity in zebrafish locomotive circuit development mediated by electrical pacemaker interneurons

This study shows that pacemaker interneurons synchronize motor neuron activity in zebrafish embryos through electrical gap junctions, and disruptions in this process are linked to hyperactivity in Fragile X syndrome models.

A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in Caenorhabditis elegans

The paper shows hyperpolarizing neurons in C. elegans use undocked innexin hemichannels to transmit temperature information independently of synaptic vesicle exocytosis.

Astroglial gap junctions strengthen hippocampal network activity by sustaining afterhyperpolarization via KCNQ channels

The paper shows astroglial gap junctions enhance hippocampal network activity by maintaining afterhyperpolarization through KCNQ channels, independent of glutamate or metabolic factors.

CFI-1/ARID3 functions unilaterally to restrict gap junction formation in C. elegans

The paper identifies CFI-1/ARID3's role in regulating gap junction formation between specific neurons in C. elegans, showing unilateral control over connectivity.

Formation of recurring transient Ca2+-based intercellular communities during Drosophila hematopoiesis

The paper identifies self-organized transient signaling hotspots in Drosophila hematopoiesis using Ca2+ signaling and computational analysis.

Gap junction mediated bioelectric coordination is required for slow muscle development, organization, and function

The paper identifies gjd4/Cx46.8 as a gap junction protein essential for bioelectric signaling in zebrafish slow muscle development and function, showing its role in coordinating neural and muscular activity.

Electrical Coupling between Parvalbumin Basket Cells is Reduced after Experimental Status Epilepticus

This study shows that electrical coupling between parvalbumin basket cells decreases after experimental status epilepticus in rats, without affecting coupling coefficient.

Specific configurations of electrical synapses filter sensory information to drive choices in behavior

The paper shows that electrical synapses in C. elegans filter sensory information to guide context-specific behavioral choices by modulating neuronal excitability and integration of temperature stimuli.

Simulation of gap junction formation reveals critical role of cysteines in connexon coupling

The paper simulates gap junction formation and finds that cysteine residues are critical for connexon coupling and stabilization of gap junction structures.

Gap junction and amino acid import in somatic cells promote germ cell growth

The paper shows that gap junctions and amino acid import in somatic cells support germ cell growth in Drosophila by enabling metabolic transfer and regulating translation.

Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins

This study identifies Neurobeachin's role in restricting electrical synapse proteins to dendrites in zebrafish neurons.

Innexin-mediated adhesion between glia is required for axon ensheathment in the peripheral nervous system

This study identifies Inx2 as essential for glial adhesion in Drosophila peripheral nerves, ensuring proper axon ensheathment without requiring gap junction function.

D-type K+ current controls the function of electrically coupled neurons in a species-specific fashion

The paper shows that D-type K+ current differences between rat and mouse MesV neurons affect electrical coupling efficiency and network function.

Insulin docking within the open hemichannel of connexin 43 may reduce risk of amyotrophic lateral sclerosis

The paper investigates how insulin interacts with connexin 43 hemichannels and suggests this interaction may reduce ALS risk by blocking toxic substance transfer.

Astrocytic Gapjinc (TMEM43) modulates gap junction networks by facilitating transjunctional potentials

This study identifies TMEM43 as a pH-sensing cation channel that modulates gap junction networks in the hippocampus, preventing neuronal hyperexcitability and supporting memory retrieval.