Reproductive System and Pregnancy

Eomesodermin defines uterine NK cells crucial for pregnancy success in mice

This study identifies Eomesodermin as essential for the development of uterine NK cells in mice, showing their critical role in successful pregnancy.

A developmental program of early residency promotes the differentiation of divergent uterine NK cell subsets in humans

This study identifies a developmental program in human uterine NK cells that links tissue residency with divergent effector functions through TGF-β responsive gene regulation.

Comparative single cell analysis reveals complex patterns of cell type and cell signaling innovations at the fetal-maternal interface

This paper compares single-cell data across six mammalian species to uncover evolutionary patterns in cell types and signaling at the fetal-maternal interface, finding conserved gene signatures and stepwise evolution of decidual cells.

Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage

The frequency of menstrual cycles with a suboptimal decidual reaction determines the recurrence risk of miscarriage.

Converging cytokine and metabolite networks shape asymmetric T cell fate at the term human maternal-fetal interface

The paper identifies cytokine and metabolite networks that regulate T cell fate at the human maternal-fetal interface, showing how they restrain T cells in an antigen-independent manner.

Superficial stromal cell population in the mouse uterus require METTL14 for development and functional competence to support embryo implantation

This study shows that METTL14 is essential for maintaining superficial stromal cells in the mouse uterus, which are necessary for embryo implantation.

CTCF is crucial for decidualization of uterine stromal cells through facilitating HOXA11 expression

This study shows CTCF is essential for early decidualization by promoting HOXA11 expression, and its loss causes infertility in mice.

Inflammatory markers in pregnancy - surprisingly stable. Mapping trajectories and drivers in four large cohorts.

This study examines inflammatory markers during pregnancy across four cohorts, finding that cytokines show high individual stability and genetic influence, while CRP is more influenced by BMI and polygenic factors.

Expression of Lysyl Oxidase Family Enzymes During Human Endometrial Decidualization

This study examines LOX family enzyme expression during human endometrial decidualization, finding decreased gene and protein levels for some LOXs but stable secretion and matrix remodeling.

NAT10 governs uterine function and fertility by stabilizing progesterone receptor mRNA via ac4C modification

This study shows NAT10 stabilizes progesterone receptor mRNA via ac4C modification, essential for uterine function and fertility in humans and mice.

Interleukin-27 is antiviral at the maternal-fetal interface.

This study identifies IL-27 as an antiviral cytokine at the maternal-fetal interface, showing it restricts Zika virus infection in placental trophoblast organoids and mouse models.

The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy

This study identifies ATG14's role in preventing unscheduled pyroptosis in the oviduct, ensuring proper embryo transport during early pregnancy.

Bioinformatics analysis of next generation sequencing data reveals novel biomarkers and signaling pathways associated with recurrent implantation failure

The paper identifies differentially expressed genes and signaling pathways in recurrent implantation failure using bioinformatics analysis of next-generation sequencing data.

Uterine stromal but not epithelial PTGS2 is critical for murine pregnancy success

This study shows that uterine stromal PTGS2 is essential for post-implantation embryo development, while epithelial PTGS2 is not required for early pregnancy success.

Endometrial zinc transporter Slc39a10/Zip10 is indispensable for progesterone responsiveness and successful pregnancy in mice

This study shows that Slc39a10/Zip10 is essential for zinc homeostasis in the endometrium, which is required for progesterone signaling and successful pregnancy in mice.

Decidual natural killer cells promote extravillous trophoblast developmental pathways: evidence from trophoblast organoid co-cultures

The paper shows that decidual natural killer cells promote trophoblast differentiation towards extravillous trophoblasts through MMP secretion and collagen remodeling in co-culture experiments.

Loss of PRICKLE1 leads to abnormal endometrial epithelial architecture, decreased embryo implantation, and reduced fertility in mice.

This study shows that loss of PRICKLE1 in mouse endometrial epithelium causes abnormal architecture, reduced implantation, and infertility by disrupting cell polarity, cytokinesis, and epithelial-mesenchymal transition.

An evolutionarily conserved microRNA, miR-185, regulates key pathways that may contribute to implantation failure.

This study shows miR-185-5p regulates pathways linked to implantation failure by altering protein expression and CNP family gene activity in endometrial cells.

RNA sequencing reveals the developmental onset of autosomal gene expression differences in male and female extravillous trophoblasts

The paper compares gene expression differences between male and female extravillous trophoblasts using bulk and single-cell RNA sequencing across the first trimester, identifying autosomal gene differences emerging after week 10 of gestation.

Hallmarks of uterine receptivity predate placental mammals

This paper compares single-cell transcriptomes of uterine and embryonic tissues across rodents and opossums to show that marsupial uteri activate an ancestral signaling axis similar to eutherian implantation, but with inhibitory signals preventing invasion.

Changes in the cellular composition of the endometrium during the implantation window are associated with recurrent pregnancy loss

The paper uses single-cell RNA sequencing to identify changes in endometrial cell populations and their interactions in women with recurrent pregnancy loss, linking these changes to altered cellular communication and potential mechanisms of implantation failure.

Natural killer cell function is regulated by TGF-β signaling in pregnancy and tumor progression

The paper identifies TGF-β signaling as a regulator of natural killer cell function in both pregnancy and tumor progression by analyzing immune compartment dynamics in human and mouse models.

Maternal obesogenic diet disrupts mid-gestation decidual immune and vascular homeostasis without impairing spiral artery remodelling

Single-cell transcriptomic analysis of immune cell dynamics in the healthy human endometrium

The paper analyzes single-cell transcriptomes from healthy human endometrium across reproductive stages to understand immune cell dynamics and identify potential biomarkers for reproductive diseases.

The role of dietary patterns in the polarization of angiogenic uterine Natural Killer cells during murine pregnancy

This study examines how different dietary patterns affect angiogenic uNK cell polarization and pregnancy outcomes in mice, finding that high-fat diets significantly impact uNK function compared to other diets.

Human placental organoids as a model to probe early gestation maternal immune dynamics

This study uses human placental organoids to investigate trophoblast subtypes' roles in modulating maternal immune responses and shows 3D culture affects immunomodulation differently than 2D culture.

Scoping Review of Maternal Monocytes and the Syncytiotrophoblast: Bi-Directional Communication in the Intervillous Space

This review examines maternal monocyte-trophoblast interactions in the intervillous space, identifying four categories of interaction and highlighting their roles in maternal disease.

Murine uterine gland branching is necessary for gland function in implantation

This study shows that branched uterine glands are necessary for pre-implantation LIF expression and successful embryo implantation in mice.

Yes Associated Transcriptional Regulator 1 (YAP1) and WW Domain Containing Transcription Regulator (WWTR1) are required for murine pregnancy initiation

This study shows YAP1 and WWTR1 are essential for decidualization and pregnancy in mice, with pdKO mice showing subfertility and altered gene expression.

The embryo-derived protein PDI is highly conserved among placental mammals and alters the function of the endometrium in species with different implantation strategies.

The paper shows that PDI, a conserved protein, alters endometrial function in species with different implantation strategies by modifying transcriptomes and secretomes.