D. Wu

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

A Novel ARNT-Dependent HIF-2α Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction

This study identifies HIF2/ARNT as a protective axis in cardiac endothelial cells post-MI, preventing vascular leakage and inflammation through suppression of IL6.

Unfolded Protein Response Factor ATF6 Augments T Helper Cell Responses and Promotes Mixed Granulocytic Airway Inflammation

This study shows ATF6 enhances TH2 and TH17 cell responses and contributes to mixed granulocytic airway inflammation, suggesting ATF6 inhibition as a potential therapy for steroid-resistant asthma.

Continuous optical detection of small-molecule analytes in complex biomatrices

This paper introduces an optical biosensor system for continuous detection of biomarkers in complex samples, achieving high sensitivity and long-term monitoring of dopamine and cortisol.

Bovine milk glycoproteins inhibit SARS-CoV-2 and influenza virus co-infection

This study shows that galactosylated glycoproteins from bovine milk inhibit both SARS-CoV-2 and influenza virus by blocking their interaction with ACE2.

Diffsig: Associating Risk Factors With Mutational Signatures

Diffsig estimates associations between risk factors and mutational signatures using a Bayesian model, confirming known cancer mechanisms in breast cancer data.

Discovery of the gut microbial enzyme responsible for bilirubin reduction to urobilinogen

This study identifies BilR, a gut microbial enzyme that reduces bilirubin to urobilinogen, and shows its prevalence in healthy adults and decline in neonates and IBD patients.

Multimodal meta-analysis of fecal metagenomes reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer

This study identifies microbial single nucleotide variants (SNVs) as superior biomarkers for early detection of colorectal cancer, outperforming species-level signatures in multiple validation cohorts.

Loss of WNT5 Proteins Reprograms Neutrophils in the Spleen to Provide Protection for DSS-Induced Colitis

This study shows that loss of WNT5A and WNT5B in mice protects against DSS-induced colitis by reprogramming spleen neutrophils to suppress inflammation.

Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus

This study shows that Fzd6 deficiency in ciliated cells reduces pulmonary inflammation-induced cell death by increasing Akr1b8 expression and protecting against ferroptosis.

Spatial-temporal evolution characteristics of land use and its driving factor analysis during the period of 2000-2020 in Putian City, Fujian Province

This study analyzes land use changes and driving factors in Putian City from 2000 to 2020 using remote sensing data and statistical methods.

Cryo-EM Structure of the 50S-HflX Complex Reveals a Novel Mechanism of Antibiotic Resistance in E. coli

The paper presents a cryo-EM structure of the E. coli 50S-HflX complex, revealing how HflX interacts with the ribosome and contributes to antibiotic resistance by displacing antibiotics from the peptidyl transferase center.

The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8+ T Cells

This study identifies Cul5 as a negative feedback regulator of CD8+ T cell signaling and anti-tumor activity, showing its knockout enhances tumor control through proteomic and signaling changes.

Structural and Functional Insights into the Action Mode of A Mitochondrial AAA+ Disaggregase CLPB

The paper was withdrawn due to duplicate posting and is no longer available for citation.

Efficient Multi-Label Attribute Classification and Recognition of Microbiological Bacteria Based on Deep Learning and model fine-tuning

This paper proposes a deep learning model for multi-label bacterial classification, showing it is lighter, faster, more accurate, and efficient than existing methods.

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

Sticky Pi, an AI-powered smart insect trap for community chronoecology

The Sticky Pi trap uses AI to monitor insect activity patterns, revealing daily rhythms and community temporal niches without targeting specific species.

Metformin Alleviates Arthrofibrosis in Rat via Fibroblast Metabolic Reprogramming

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

Ubiquitin-like cGAS chain formation by a super enzyme activates anti-phage response

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

Spatiotemporal atlas of the fetal brain depicts cortical developmental gradient in Chinese population

This study constructs a spatiotemporal MRI atlas of fetal brain development in Chinese fetuses, revealing a central-to-peripheral cortical growth gradient and dynamic structural asymmetry.

Dissecting the conformational complexity and flipping mechanism of a prokaryotic heme transporter

The paper identifies CydDC as a heme flippase essential for cytochrome bd maturation, revealing its conformational mechanism through cryo-EM and molecular dynamics.

Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein

The paper analyzes sequence and structural variability in the SARS-CoV-2 nucleocapsid protein, finding high mutability and structural plasticity linked to enhanced viral assembly efficiency.

In vivo correction of cystic fibrosis mediated by PNA nanoparticles

This study demonstrates systemic gene editing using PNA nanoparticles to correct the F508del CFTR mutation in mice, showing partial CFTR function restoration and tissue-specific correction without off-target effects.

Conserved Untranslated Regions of Multipartite Viruses: Natural Markers of Novel Viral Genomic Components and Tags of Viral Evolution

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.

Horizontal Transfers Lead to the Birth of Momilactone Biosynthetic Gene Clusters in Grass

This study shows that horizontal gene transfer created momilactone biosynthetic gene clusters in grasses, with subsequent gene recruitment and loss shaping their evolution.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

Horizontal Transfer and Evolution of the Biosynthetic Gene Cluster for Benzoxazinoid

This study identifies horizontal transfer of a biosynthetic gene cluster for benzoxazinoids among grasses, revealing evolutionary mechanisms and selection pressures.

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

Directed Evolution of Aptamer Discovery Technologies

This paper describes four techniques to improve aptamer discovery, enabling efficient isolation of high-affinity and specific aptamers for challenging targets.

Modeling Macroscopic Currents of Ion Channels

The paper introduces an improved model for ion-channel currents that allows for multiple states and incorporates conductance and open probability, demonstrating its applicability with BK and MthK potassium channel data.