F. Chen

Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane

This study shows HBV envelope proteins are present on the host cell plasma membrane and can be targeted by T-cells for therapeutic purposes.

High-resolution Cell Atlas of Pig Lung and Online Platform Exploring for Lung Single Cell

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer's R47H mutant does the opposite

The paper shows wild-type sTREM2 inhibits Aβ aggregation and neurotoxicity, while the R47H variant promotes Aβ aggregation and neurotoxicity.

A critical role of stable grain filling rate in maximizing rice yield revealed by whole plant carbon nitrogen interaction modeling

This study develops a whole-plant carbon nitrogen interaction model to show that a stable grain filling rate from flowering to harvest maximizes rice yield, validated in high-yielding cultivars.

Lung macrophages mediate helminth resistance through differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

This study identifies lung macrophages that kill helminths by depleting arginine through differential activation of recruited monocyte-derived alveolar macrophages.

Evolution of co-regulatory network of C4 metabolic genes and TFs in the genus Flaveria: go anear or away in the intermediate species?

This study constructs TF co-regulatory networks for C4 metabolic genes across four Flaveria species, revealing species-specific co-regulations and evolutionary rewiring of TF networks during C4 photosynthesis development.

Tissue-specific accumulation profiles of phorbol esters in Jatropha curcas and gene induction in response to abiotic and biotic stresses

The paper analyzes phorbol ester distribution in Jatropha curcas tissues and links it to gene expression under various stresses.

Human IFITM3 restricts Chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction

This study shows IFITM3 restricts CHIKV and MAYV infection and is counteracted by these viruses, with a variant showing similar antiviral activity to wild-type.

Repopulating Kupffer Cells Originate Directly from Hematopoietic Stem Cells

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

Single cell transcriptomics reveal disrupted kidney filter cell-cell interactions after early and selective podocyte injury

The paper uses single-cell RNA sequencing to identify early transcriptional changes in kidney cells after podocyte injury, revealing disrupted cell-cell interactions that contribute to chronic kidney disease progression.

Enabling in vivo Analysis Via Nanoparticle-mediated Intracellular Assay Probe Delivery: Using RAS as the Prototype

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

Arhopalus rusticus (Coleoptera: Cerambycidae): a new vector for pine wood nematode, Bursaphelenchus xylophilus (Nematoda: Aphelenchoididae)

The paper investigates the ability of Arhopalus rusticus to transmit pine wood nematodes, finding that 12 beetles can transmit the nematodes through feeding on pine needles.

One-Step Rapid Quantification of SARS-CoV-2 Virus Particles via Low-Cost Nanoplasmonic Sensors in Generic Microplate Reader and Point-of-Care Device

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

A Chemical-genetics and Nanoparticle Enabled Approach for in vivo Protein Kinase Analysis

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

Assessment of whether published non-Cochrane systematic reviews of nursing follow the review protocols registered in the International Prospective Register of Systematic Reviews (PROSPERO): A comparative study

This study compares non-Cochrane nursing systematic reviews with their PROSPERO-registered protocols, finding widespread discrepancies with few explanations.

Post-transcriptional splicing can occur in a slow-moving zone around the gene

The paper uses imaging techniques to show that splicing occurs in a slow-moving zone near the transcription site, suggesting a model where splicing is post-transcriptional but occurs close to transcription.

Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

A potent antibiofilm agent inhibits and eradicates mono- and multi-species biofilms

This paper identifies elasnin as a potent antibiofilm agent that inhibits mono- and multi-species biofilms with low toxicity and resistance risk.

Global Profiling of 2-hydroxyisobutyrylome in Common Wheat

This study profiles the 2-hydroxyisobutyrylome in common wheat, identifying Khib modification sites and their roles in metabolic pathways and enzyme regulation.

Effect of choline-phosphate cytidylyltransferase gene (pcyt-1) expression on departure of pine wood nematode, Bursaphelenchus xylophilus (Nematoda: Aphelenchoididae), from Monochamus alternatus (Coleoptera:Cerambycidae)

The paper investigates the role of pcyt-1 gene expression in pine wood nematode departure from its beetle vector, finding that up-regulation of pcyt-1 promotes lipid degradation and motility necessary for departure.

Single cell transcriptomic heterogeneity in invasive ductal and lobular breast cancer cells

The paper uses single-cell RNA sequencing to compare transcriptional heterogeneity between invasive ductal and lobular breast cancer cell lines, identifying CDH1 loss effects and potential mediators of ILC-specific features.

Hypercapnia Suppresses Macrophage Antiviral Activity and Increases Mortality of Influenza A 1 Infection via Akt1

This study shows hypercapnia suppresses macrophage antiviral activity and increases influenza A mortality via Akt1 activation in mice.

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson's disease mouse brain

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

Novel pelagiphages prevail in the ocean

This study isolates and characterizes ten novel pelagiphages infecting Pelagibacter strains, revealing their genetic diversity, global distribution, and ecological significance.

The effect of feeding behavior of Monochamus alternatus (Coleoptera: Cerambycidae) on the departure of pine wood nematode, Bursaphelenchus xylophilus (Nematoda: Aphelenchoididae)

This study investigates how the feeding behavior of Monochamus alternatus affects the departure of pine wood nematodes, finding no significant difference but linking increased motility and oxidative phosphorylation to nematode departure.

Geomagnetic field intensity as a cue for the regulation of insect migration

The paper tests how changes in geomagnetic field intensity affect migration-related traits in the brown planthopper, finding responses in morphology, behavior, and physiology.

Geomagnetic field absence reduces adult body weight of a migratory insect by disrupting feeding behavior and appetite regulation

This study shows that absence of geomagnetic field reduces feeding in brown planthopper nymphs, leading to lower body weight and altered glucose levels and appetite-related gene expression.