F. Li

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

Atherosclerosis is a smooth muscle cell-driven tumor-like disease

This study shows atherosclerosis shares tumor-like features with smooth muscle cells, including genomic instability and cancer gene networks, and demonstrates anti-cancer drugs can treat it.

Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression

The paper identifies a paracrine signaling cascade involving SHH, WNT, and VEGF that suppresses angiogenesis in pancreatic cancer using tumor explant models.

Excessive apoptosis of naïve T cells resulting hyperactivation as a cause of mammalian aging

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.

Structural insights into transcription activation mechanism of the global regulator GlnR from actinobacteria

This paper reports the crystal and cryo-EM structures of GlnR-DNA and GlnR-TAC complexes, revealing the transcription activation mechanism of GlnR in actinobacteria.

ZNF524 directly interacts with telomeric DNA and supports telomere integrity

This study identifies ZNF524 as a telomere-binding protein that maintains telomere integrity by supporting TRF2/RAP1 localization and preventing DNA damage and recombination.

Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

Characterization of N distribution in different organs of winter wheat using UAV-based remote sensing

This study evaluates UAV-based remote sensing for predicting nitrogen content and nitrogen agronomic efficiency in winter wheat organs using vegetation indices and texture features.

Molecular and genetic mechanisms conferring dissolution of dioecy in Diospyros oleifera Cheng

This study identifies molecular and genetic mechanisms underlying the transition from dioecy to monoecy in Diospyros oleifera using genome-wide analyses of 150 accessions.

Gene inversion triggered origination of brackish archaeal heterotrophs in the aftermath of the Cryogenian Snowball Earth

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

An Improved Algorithm for Inferring Mutational Parameters from Bar-Seq Evolution Experiments

The paper introduces an improved algorithm for inferring mutational parameters from Bar-Seq evolution experiments, showing better performance in identifying adaptive mutations and their parameters.

Early life adversity and adult social relationships have independent effects on survival in a wild animal model of aging

The paper shows early life adversity and adult social isolation independently reduce survival in wild baboons, supporting both health selection and social causation hypotheses.

Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

The paper determines the structure of VGLUT2 with a glutamate analog bound, revealing mechanisms of substrate recognition, electrostatic interactions, and palmitoylation's role in transporter retrieval.

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

The paper profiles 218 cytotoxic and nuisance compounds in U-2 OS cells to create reference compounds for improving assay optimization and compound prioritization in cellular morphology assays.

In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation

This study uses two-photon microscopy to observe astrocyte reactivity in mouse brains after intracortical microelectrode implantation, revealing distinct spatiotemporal dynamics compared to other glial cells.

Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.

Predicting neoadjuvant chemotherapy benefit using deep learning from stromal histology in breast cancer

This study uses deep learning to predict neoadjuvant chemotherapy benefit in breast cancer using stromal histology, introducing the TS-score which outperforms existing predictors.

Engineered bacteria recruit and orchestrate anti-tumor immunity

The paper engineers bacteria to release chemokines that recruit immune cells into tumors, enhancing anti-tumor immunity in mouse models.

GWAS identifies candidate genes controlling adventitious rooting in Populus trichocarpa

This study uses GWAS to identify 277 candidate genes associated with adventitious rooting in Populus trichocarpa, highlighting roles in hormone signaling, cell division, and reactive oxygen species.

GWAS identifies candidate regulators of in planta regeneration in Populus trichocarpa

This study uses GWAS to identify candidate genes regulating in planta regeneration in Populus trichocarpa, finding over 200 genes involved in cell adhesion, stress signaling, and hormone pathways.

Evolution towards small colony variants of pandemic multidrug resistant ST131 Escherichia coli isolates from a 10-year bone infection

The paper characterizes the evolution of multidrug-resistant ST131 E. coli isolates in a chronic bone infection, identifying genomic changes linked to small colony variants and persistence.

Suppression of tumor/host intrinsic CMTM6 drives anti-tumor cytotoxicity in a PD-L1 independent manner

This study shows that suppressing CMTM6 in tumors or hosts enhances anti-tumor immunity independently of PD-L1, suggesting CMTM6 as a target for gene therapy.

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

Biochemical Characterization of a Fungal Bifunctional Type I Diterpene Synthase Brings a Cryptic Natural Product to Light

The paper identifies a tnd biosynthetic cluster in Aspergillus flavipes and characterizes a bifunctional diterpene synthase, leading to the discovery of talarodiene and its transformation into talaronoid C.

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

This study shows DDX4, a germline factor, enhances chemoresistance and motility in SCLC cells by altering metabolism and EMT-like features.

Plant-on-Chip: core morphogenesis processes in the tiny plant Wolffia australiana

This paper introduces Wolffia australiana as a model system for studying plant morphogenesis using a Plant-on-Chip culture system and advanced technologies like snRNA-seq.

Robust high-throughput phenotyping with deep segmentation enabled by a web-based annotator

This paper introduces a high-throughput plant phenotyping system with a GUI and SGIOS algorithm to streamline training data generation and improve GWAS for trait variation analysis.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.